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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F14%3A33153099%21RIV15-MSM-15110___
rdf:type
skos:Concept n17:Vysledek
dcterms:description
In order to better understand the epidemiology of fusariosis in Europe, a survey collecting information on the clinical characteristics of the patients infected by Fusarium as well as on the infecting isolates was launched. A total of 76 cases of invasive fusariosis occurring from January 2007 to June 2012 were collected and Fusarium isolates were identified by sequencing the translation elongation factor 1 alpha (TEF) gene. Also, antifungal susceptibility was tested by broth microdilution according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST) and the Etest. Disseminated disease was considered proven in 46 cases and probable in 17 cases. Localised infection was seen in 13 cases. Gibberella fujikuroi species complex (SC), including Fusarium verticillioides and F. proliferatum, and F. solani SC were the most frequent aetiology of disseminated and localised infections, respectively. The crude mortality rate was 46 %, the highest associated with F. solani SC (67 %) and F. proliferatum (62.5 %). A wide range of antifungal susceptibilities was observed. Amphotericin B was the most potent antifungal in vitro, and itraconazole the least effective. The azoles exhibited lower minimum inhibitory concentrations (MICs) against F. verticillioides strains, with posaconazole having a slightly better performance, while F. solani SC isolates were resistant to all three azoles tested. The essential agreement between the Etest and the EUCAST method was 100 % for itraconazole and voriconazole, and 96 % for amphotericin B and posaconazole. In conclusion, we confirm that fusariosis is a rare but severe event in Europe, that G. fujikuroi SC is the predominant cause of deep infections and that different species have different antifungal in vitro susceptibility patterns In order to better understand the epidemiology of fusariosis in Europe, a survey collecting information on the clinical characteristics of the patients infected by Fusarium as well as on the infecting isolates was launched. A total of 76 cases of invasive fusariosis occurring from January 2007 to June 2012 were collected and Fusarium isolates were identified by sequencing the translation elongation factor 1 alpha (TEF) gene. Also, antifungal susceptibility was tested by broth microdilution according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST) and the Etest. Disseminated disease was considered proven in 46 cases and probable in 17 cases. Localised infection was seen in 13 cases. Gibberella fujikuroi species complex (SC), including Fusarium verticillioides and F. proliferatum, and F. solani SC were the most frequent aetiology of disseminated and localised infections, respectively. The crude mortality rate was 46 %, the highest associated with F. solani SC (67 %) and F. proliferatum (62.5 %). A wide range of antifungal susceptibilities was observed. Amphotericin B was the most potent antifungal in vitro, and itraconazole the least effective. The azoles exhibited lower minimum inhibitory concentrations (MICs) against F. verticillioides strains, with posaconazole having a slightly better performance, while F. solani SC isolates were resistant to all three azoles tested. The essential agreement between the Etest and the EUCAST method was 100 % for itraconazole and voriconazole, and 96 % for amphotericin B and posaconazole. In conclusion, we confirm that fusariosis is a rare but severe event in Europe, that G. fujikuroi SC is the predominant cause of deep infections and that different species have different antifungal in vitro susceptibility patterns
dcterms:title
European Confederation of Medical Mycology (ECMM) epidemiological survey on invasive infections due to Fusarium species in Europe European Confederation of Medical Mycology (ECMM) epidemiological survey on invasive infections due to Fusarium species in Europe
skos:prefLabel
European Confederation of Medical Mycology (ECMM) epidemiological survey on invasive infections due to Fusarium species in Europe European Confederation of Medical Mycology (ECMM) epidemiological survey on invasive infections due to Fusarium species in Europe
skos:notation
RIV/61989592:15110/14:33153099!RIV15-MSM-15110___
n3:aktivita
n4:N
n3:aktivity
N
n3:cisloPeriodika
9
n3:dodaniDat
n7:2015
n3:domaciTvurceVysledku
n14:4123263
n3:druhVysledku
n18:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
15217
n3:idVysledku
RIV/61989592:15110/14:33153099
n3:jazykVysledku
n16:eng
n3:klicovaSlova
epidemiology of fusariosis in Europe
n3:klicoveSlovo
n8:epidemiology%20of%20fusariosis%20in%20Europe
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[695CF5D37743]
n3:nazevZdroje
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
n3:obor
n12:EE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
19
n3:rokUplatneniVysledku
n7:2014
n3:svazekPeriodika
33
n3:tvurceVysledku
Nordoy, I. Hamal, Petr Esposto, Mc Prigitano, A. Kolarovic, J. Tortorano, Am Arsenijevic, V Arsic Ivanovic, D. Klingsport, L. Paripovic, L.
n3:wos
000340538700021
s:issn
0934-9723
s:numberOfPages
8
n15:doi
10.1007/s10096-014-2111-1
n11:organizacniJednotka
15110