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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F14%3A33151900%21RIV15-MSM-15110___
rdf:type
skos:Concept n12:Vysledek
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/S0040403914007588
dcterms:description
The targeted solid-phase synthesis of 3-hydroxyquinolin-4(1H)-one derivatives is described. The primary and secondary amines, 3-amino-4-(methoxycarbonyl)benzoic acid and 2-bromo-1-(4-chloro-3-nitrophenyl)ethanone were used as starting materials. The structures of the final compounds were designed in accordance with previous information obtained from structure-activity relationship studies of similar cytotoxic derivatives. Representative prepared compounds were subjected to in vitro screening of cytotoxic activity against various cancer cell lines; the results obtained are discussed. Fluorescence properties of selected compounds were also studied to compare the data with those obtained in analogous derivatives. The targeted solid-phase synthesis of 3-hydroxyquinolin-4(1H)-one derivatives is described. The primary and secondary amines, 3-amino-4-(methoxycarbonyl)benzoic acid and 2-bromo-1-(4-chloro-3-nitrophenyl)ethanone were used as starting materials. The structures of the final compounds were designed in accordance with previous information obtained from structure-activity relationship studies of similar cytotoxic derivatives. Representative prepared compounds were subjected to in vitro screening of cytotoxic activity against various cancer cell lines; the results obtained are discussed. Fluorescence properties of selected compounds were also studied to compare the data with those obtained in analogous derivatives.
dcterms:title
Synthesis, cytotoxic activity and fluorescence properties of a set of novel 3-hydroxyquinolin-4(1H)-ones Synthesis, cytotoxic activity and fluorescence properties of a set of novel 3-hydroxyquinolin-4(1H)-ones
skos:prefLabel
Synthesis, cytotoxic activity and fluorescence properties of a set of novel 3-hydroxyquinolin-4(1H)-ones Synthesis, cytotoxic activity and fluorescence properties of a set of novel 3-hydroxyquinolin-4(1H)-ones
skos:notation
RIV/61989592:15110/14:33151900!RIV15-MSM-15110___
n3:aktivita
n14:P
n3:aktivity
P(ED0030/01/01), P(EE2.3.20.0009), P(EE2.4.31.0130)
n3:cisloPeriodika
26
n3:dodaniDat
n8:2015
n3:domaciTvurceVysledku
n4:2484994 n4:1759256 n4:7608543
n3:druhVysledku
n11:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
49018
n3:idVysledku
RIV/61989592:15110/14:33151900
n3:jazykVysledku
n5:eng
n3:klicovaSlova
Solid-phase synthesis, hydroxyquinolinones, cytotoxic activity, fluorescence
n3:klicoveSlovo
n7:Solid-phase%20synthesis n7:cytotoxic%20activity n7:hydroxyquinolinones n7:fluorescence
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[7AF91DE1E7BE]
n3:nazevZdroje
Tetrahedron Letters
n3:obor
n20:CC
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
5
n3:projekt
n9:EE2.4.31.0130 n9:ED0030%2F01%2F01 n9:EE2.3.20.0009
n3:rokUplatneniVysledku
n8:2014
n3:svazekPeriodika
55
n3:tvurceVysledku
Džubák, Petr Motyka, Kamil Hajdúch, Marián Kadrič, Jasna Soural, Miroslav
n3:wos
000337868300004
s:issn
0040-4039
s:numberOfPages
4
n13:doi
10.1016/j.tetlet.2014.04.121
n18:organizacniJednotka
15110