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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F14%3A33151840%21RIV15-MSM-15110___
rdf:type
skos:Concept n20:Vysledek
rdfs:seeAlso
http://pubs.acs.org/doi/pdf/10.1021/cm404053v
dcterms:description
Clustering of biocompatible magnetic iron oxide nanocrystallites (MIONs) is a synthetic strategy which improves magnetic manipulation, imaging, and sensing for biomedical applications. In this work we describe the synthesis of condensed clustered MIONs obtained through biomineralization and epitaxial aggregation in the presence of alginate at ambient conditions, mimicking the process that so far has been achieved only by nature, in iron-oxidizing bacteria. These ondensed-type magnetic nanostructures exhibit higher magnetophoretic responses compared to other types of magnetic colloids and clustered systems. The soft environmental conditions used for the synthesis of the magnetic nanosystems enables the alginate coating material to retain high drug loading ability for the doxorubicin molecule as well as strong binding proclivity for radionuclides. The strong binding of doxorubicin forms the physical basis to obtain magnetic nanocarriers, where the selective release of the drug occurs only under the action of external stimuli, such as remote magnetic hyperthermia or increased temperature (i.e., inflamed tissue). Furthermore, the strong binding proclivity of radionuclides facilitates in vivo SPECT imaging. The witnessed properties are obtained by using only ?17 wt % alginate content in the magnetic superstructures; thus, very high saturation magnetization value is imparted to the condensed system, expressed in terms of the hybrid's mass. In spite of the fact that the magnetic nanoassemblies are characterized by low hydrodynamic diameter, ?45 nm, the transverse relaxivity reaches the remarkable value of 250 s?1 mM?1 Fe (for negative MION contrast agents of this size), a property that validates the use of these nanostructures as effective MRI contrast agents. Clustering of biocompatible magnetic iron oxide nanocrystallites (MIONs) is a synthetic strategy which improves magnetic manipulation, imaging, and sensing for biomedical applications. In this work we describe the synthesis of condensed clustered MIONs obtained through biomineralization and epitaxial aggregation in the presence of alginate at ambient conditions, mimicking the process that so far has been achieved only by nature, in iron-oxidizing bacteria. These ondensed-type magnetic nanostructures exhibit higher magnetophoretic responses compared to other types of magnetic colloids and clustered systems. The soft environmental conditions used for the synthesis of the magnetic nanosystems enables the alginate coating material to retain high drug loading ability for the doxorubicin molecule as well as strong binding proclivity for radionuclides. The strong binding of doxorubicin forms the physical basis to obtain magnetic nanocarriers, where the selective release of the drug occurs only under the action of external stimuli, such as remote magnetic hyperthermia or increased temperature (i.e., inflamed tissue). Furthermore, the strong binding proclivity of radionuclides facilitates in vivo SPECT imaging. The witnessed properties are obtained by using only ?17 wt % alginate content in the magnetic superstructures; thus, very high saturation magnetization value is imparted to the condensed system, expressed in terms of the hybrid's mass. In spite of the fact that the magnetic nanoassemblies are characterized by low hydrodynamic diameter, ?45 nm, the transverse relaxivity reaches the remarkable value of 250 s?1 mM?1 Fe (for negative MION contrast agents of this size), a property that validates the use of these nanostructures as effective MRI contrast agents.
dcterms:title
Theranostics of Epitaxially Condensed Colloidal Nanocrystal Clusters, through a Soft Biomineralization Route Theranostics of Epitaxially Condensed Colloidal Nanocrystal Clusters, through a Soft Biomineralization Route
skos:prefLabel
Theranostics of Epitaxially Condensed Colloidal Nanocrystal Clusters, through a Soft Biomineralization Route Theranostics of Epitaxially Condensed Colloidal Nanocrystal Clusters, through a Soft Biomineralization Route
skos:notation
RIV/61989592:15110/14:33151840!RIV15-MSM-15110___
n3:aktivita
n12:P
n3:aktivity
P(ED2.1.00/03.0058), P(EE2.3.20.0017), P(EE2.3.20.0058), P(LH12085)
n3:cisloPeriodika
FEB
n3:dodaniDat
n16:2015
n3:domaciTvurceVysledku
n11:7669135
n3:druhVysledku
n10:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
50276
n3:idVysledku
RIV/61989592:15110/14:33151840
n3:jazykVysledku
n15:eng
n3:klicovaSlova
Route; Biomineralization; Soft; Clusters; Nanocrystal; Colloidal; Condensed; Epitaxially; Theranostics
n3:klicoveSlovo
n4:Route n4:Biomineralization n4:Condensed n4:Colloidal n4:Theranostics n4:Soft n4:Epitaxially n4:Nanocrystal n4:Clusters
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[6946A13DDC32]
n3:nazevZdroje
Chemistry of Materials
n3:obor
n17:BO
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
12
n3:projekt
n14:EE2.3.20.0017 n14:LH12085 n14:EE2.3.20.0058 n14:ED2.1.00%2F03.0058
n3:rokUplatneniVysledku
n16:2014
n3:svazekPeriodika
26
n3:tvurceVysledku
Diwoky, Clemens Fragogeorgi, Eirini Tuček, Jiří Tománková, Kateřina Zoppellaro, Giorgio Kolokithas-Ntoukas, Argiris Loudos, George Zbořil, Radek Kouzoudis, Dimitris Poláková, Kateřina Avgoustakis, Konstantinos Bakandritsos, Aristides
n3:wos
000333539300012
s:issn
0897-4756
s:numberOfPages
13
n18:doi
10.1021/cm404053v
n9:organizacniJednotka
15110