This HTML5 document contains 40 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n10http://localhost/temp/predkladatel/
n12http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n9http://linked.opendata.cz/ontology/domain/vavai/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n4http://linked.opendata.cz/ontology/domain/vavai/riv/
n3http://bibframe.org/vocab/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n13http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n11http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n16http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n18http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n15http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F61989592%3A15110%2F14%3A33150458%21RIV15-MSM-15110___/
n17http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n5http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n6http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F14%3A33150458%21RIV15-MSM-15110___
rdf:type
n9:Vysledek skos:Concept
dcterms:description
Lovastatin showed anti-proliferative effects in vitro and led to significantly smaller tumor sizes in vivo compared to vehicle-treatment. 13cRA promoted tumor cell growth in vitro and led to significantly larger viable tumor mass and significantly faster increase of viable tumor mass in vivo over time compared to vehicle- and lovastatin-treatment. However, when combined with lovastatin, 13cRA enhanced the anti-proliferative effect of lovastatin in vivo. The combination-treated mice showed slowest tumor growth of all groups with significantly slower tumor growth compared to the vehicle-treated mice and significantly smaller tumor sizes. Moreover, the combination-treated group displayed the smallest size of viable tumor mass and the slowest increase in viable tumor mass over time of all groups, with a significant difference compared to the vehicle- and 13cRA-treated group. The combination-treated tumors showed highest extent of necrosis, lowest median microvessel density (MVD) and highest expression of alpha-smooth muscle actin. The combination of highe MVD and low alpha-SMA is a predictor of poor prognosis in other tumor entities. Lovastatin showed anti-proliferative effects in vitro and led to significantly smaller tumor sizes in vivo compared to vehicle-treatment. 13cRA promoted tumor cell growth in vitro and led to significantly larger viable tumor mass and significantly faster increase of viable tumor mass in vivo over time compared to vehicle- and lovastatin-treatment. However, when combined with lovastatin, 13cRA enhanced the anti-proliferative effect of lovastatin in vivo. The combination-treated mice showed slowest tumor growth of all groups with significantly slower tumor growth compared to the vehicle-treated mice and significantly smaller tumor sizes. Moreover, the combination-treated group displayed the smallest size of viable tumor mass and the slowest increase in viable tumor mass over time of all groups, with a significant difference compared to the vehicle- and 13cRA-treated group. The combination-treated tumors showed highest extent of necrosis, lowest median microvessel density (MVD) and highest expression of alpha-smooth muscle actin. The combination of highe MVD and low alpha-SMA is a predictor of poor prognosis in other tumor entities.
dcterms:title
Combination of 13-cis retinoid acid and lovastatin: marked anti-tumor potential in vivo in a pheochromocytoma allograft model in female athymic nude mice Combination of 13-cis retinoid acid and lovastatin: marked anti-tumor potential in vivo in a pheochromocytoma allograft model in female athymic nude mice
skos:prefLabel
Combination of 13-cis retinoid acid and lovastatin: marked anti-tumor potential in vivo in a pheochromocytoma allograft model in female athymic nude mice Combination of 13-cis retinoid acid and lovastatin: marked anti-tumor potential in vivo in a pheochromocytoma allograft model in female athymic nude mice
skos:notation
RIV/61989592:15110/14:33150458!RIV15-MSM-15110___
n4:aktivita
n18:I
n4:aktivity
I
n4:cisloPeriodika
7
n4:dodaniDat
n6:2015
n4:domaciTvurceVysledku
n12:3415597
n4:druhVysledku
n17:J
n4:duvernostUdaju
n11:S
n4:entitaPredkladatele
n15:predkladatel
n4:idSjednocenehoVysledku
7801
n4:idVysledku
RIV/61989592:15110/14:33150458
n4:jazykVysledku
n16:eng
n4:klicovaSlova
pheochromocytoma; 13-cis retinoic acid; lovastatin
n4:klicoveSlovo
n13:pheochromocytoma n13:13-cis%20retinoic%20acid n13:lovastatin
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[8852D5FF086A]
n4:nazevZdroje
Endocrinology
n4:obor
n5:FP
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
14
n4:rokUplatneniVysledku
n6:2014
n4:svazekPeriodika
155
n4:tvurceVysledku
Schovánek, Jan Tayem, Yasin Nolting, Svenja Giubellino, Alessio
s:issn
0013-7227
s:numberOfPages
14
n3:doi
10.1210/en.2014-1027
n10:organizacniJednotka
15110