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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F14%3A33150427%21RIV15-MSM-15110___
rdf:type
skos:Concept n18:Vysledek
rdfs:seeAlso
http://biomed.papers.upol.cz/pdfs/bio/2014/04/01.pdf
dcterms:description
Aims: MicroRNAs of the miR-29 isoforms were one of the first microRNAs identified as possible therapeutic agents in malignant hematopoiesis. The aim of our review is to summarize the current state of the knowledge on miR-29 isoforms. Methods: We performed literature searches involving miR-29 isoforms and their relationship to individual hematological malignancies, namely acute myeloid leukemia (AML), chronic lymphoblastic leukemia (CLL) and chronic myeloid leukemia (CML). We also searched for subgroups of hematological malignancies, e.g. multiple myeloma, that are regarded as members of the four general groups of leukemias. Results: A number of genes appear to be regulated by miR-29 isoforms in various physiological and pathological situations. In our view regulation of Tcl-1, Mcl-1 and DNA methyltransferases is relevant in case of hematological malignancies, hence these are the focus of this review. miR-29 isoforms also function during normal T-cell and B-cell evolution. Conclusion: MiR-29 isoforms are involved in hematological malignancies and form a potential target for treatment. However, general heterogeneity of these malignancies raises a problem of cross-talk among various factors. We propose to aid investigations in this field by use of individual cell transfections and the use of genetically characterized individual cells. Aims: MicroRNAs of the miR-29 isoforms were one of the first microRNAs identified as possible therapeutic agents in malignant hematopoiesis. The aim of our review is to summarize the current state of the knowledge on miR-29 isoforms. Methods: We performed literature searches involving miR-29 isoforms and their relationship to individual hematological malignancies, namely acute myeloid leukemia (AML), chronic lymphoblastic leukemia (CLL) and chronic myeloid leukemia (CML). We also searched for subgroups of hematological malignancies, e.g. multiple myeloma, that are regarded as members of the four general groups of leukemias. Results: A number of genes appear to be regulated by miR-29 isoforms in various physiological and pathological situations. In our view regulation of Tcl-1, Mcl-1 and DNA methyltransferases is relevant in case of hematological malignancies, hence these are the focus of this review. miR-29 isoforms also function during normal T-cell and B-cell evolution. Conclusion: MiR-29 isoforms are involved in hematological malignancies and form a potential target for treatment. However, general heterogeneity of these malignancies raises a problem of cross-talk among various factors. We propose to aid investigations in this field by use of individual cell transfections and the use of genetically characterized individual cells.
dcterms:title
The role of miR-29 isoforms in malignant hematopoiesis The role of miR-29 isoforms in malignant hematopoiesis
skos:prefLabel
The role of miR-29 isoforms in malignant hematopoiesis The role of miR-29 isoforms in malignant hematopoiesis
skos:notation
RIV/61989592:15110/14:33150427!RIV15-MSM-15110___
n3:aktivita
n11:S
n3:aktivity
S
n3:cisloPeriodika
4
n3:dodaniDat
n10:2015
n3:domaciTvurceVysledku
n8:7405774 n8:1030957
n3:druhVysledku
n14:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
43144
n3:idVysledku
RIV/61989592:15110/14:33150427
n3:jazykVysledku
n13:eng
n3:klicovaSlova
post-transcriptional regulation; leukemia; hematopoiesis; miR-29; microRNA
n3:klicoveSlovo
n4:microRNA n4:post-transcriptional%20regulation n4:miR-29 n4:hematopoiesis n4:leukemia
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[CAD23C73FA33]
n3:nazevZdroje
Biomedical Papers-Olomouc
n3:obor
n17:CE
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
3
n3:rokUplatneniVysledku
n10:2014
n3:svazekPeriodika
158
n3:tvurceVysledku
Vassanelli, Stefano Modrianský, Martin Kollinerová, Soňa
s:issn
1213-8118
s:numberOfPages
13
n19:doi
10.5507/bp.2014.029
n16:organizacniJednotka
15110