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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F14%3A33150309%21RIV15-MSM-15110___
rdf:type
skos:Concept n13:Vysledek
rdfs:seeAlso
http://aje.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=24355332
dcterms:description
The indiscriminate use of the cumulative exposure metric (the product of intensity and duration of exposure) might bias reported associations between exposure to hazardous agents and cancer risk. To assess the independent effects of duration and intensity of exposure on cancer risk, we explored effect modification of the association of cumulative exposure and cancer risk by intensity of exposure. We applied a flexible excess odds ratio model that is linear in cumulative exposure but potentially nonlinear in intensity of exposure to 15 case-control studies of cigarette smoking and lung cancer (1985-2009). Our model accommodated modification of the excess odds ratio per pack-year of cigarette smoking by time since smoking cessation among former smokers. We observed negative effect modification of the association of pack-years of cigarette smoking and lung cancer by intensity of cigarette smoke for persons who smoked more than 20-30 cigarettes per day. Patterns of effect modification were similar across individual studies and across major lung cancer subtypes. We observed strong negative effect modification by time since smoking cessation. Application of our method in this example of cigarette smoking and lung cancer demonstrated that reducing a complex exposure history to a metric such as cumulative exposure is too restrictive. The indiscriminate use of the cumulative exposure metric (the product of intensity and duration of exposure) might bias reported associations between exposure to hazardous agents and cancer risk. To assess the independent effects of duration and intensity of exposure on cancer risk, we explored effect modification of the association of cumulative exposure and cancer risk by intensity of exposure. We applied a flexible excess odds ratio model that is linear in cumulative exposure but potentially nonlinear in intensity of exposure to 15 case-control studies of cigarette smoking and lung cancer (1985-2009). Our model accommodated modification of the excess odds ratio per pack-year of cigarette smoking by time since smoking cessation among former smokers. We observed negative effect modification of the association of pack-years of cigarette smoking and lung cancer by intensity of cigarette smoke for persons who smoked more than 20-30 cigarettes per day. Patterns of effect modification were similar across individual studies and across major lung cancer subtypes. We observed strong negative effect modification by time since smoking cessation. Application of our method in this example of cigarette smoking and lung cancer demonstrated that reducing a complex exposure history to a metric such as cumulative exposure is too restrictive.
dcterms:title
Effect modification of the association of cumulative exposure and cancer risk by intensity of exposure and time since exposure cessation: a flexible method applied to cigarette smokong and lung cancer in the SYNERGY study Effect modification of the association of cumulative exposure and cancer risk by intensity of exposure and time since exposure cessation: a flexible method applied to cigarette smokong and lung cancer in the SYNERGY study
skos:prefLabel
Effect modification of the association of cumulative exposure and cancer risk by intensity of exposure and time since exposure cessation: a flexible method applied to cigarette smokong and lung cancer in the SYNERGY study Effect modification of the association of cumulative exposure and cancer risk by intensity of exposure and time since exposure cessation: a flexible method applied to cigarette smokong and lung cancer in the SYNERGY study
skos:notation
RIV/61989592:15110/14:33150309!RIV15-MSM-15110___
n4:aktivita
n19:N
n4:aktivity
N
n4:cisloPeriodika
3
n4:dodaniDat
n9:2015
n4:domaciTvurceVysledku
n11:2512343
n4:druhVysledku
n17:J
n4:duvernostUdaju
n16:S
n4:entitaPredkladatele
n6:predkladatel
n4:idSjednocenehoVysledku
13083
n4:idVysledku
RIV/61989592:15110/14:33150309
n4:jazykVysledku
n10:eng
n4:klicovaSlova
pooled analysis; lung cancer; effect modification; cumulative exposure; cigarette smoke
n4:klicoveSlovo
n5:cumulative%20exposure n5:effect%20modification n5:lung%20cancer n5:cigarette%20smoke n5:pooled%20analysis
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[374DF0779329]
n4:nazevZdroje
American Journal of Epidemiology (print)
n4:obor
n15:FN
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
45
n4:rokUplatneniVysledku
n9:2014
n4:svazekPeriodika
179
n4:tvurceVysledku
Pesch, B. Janout, Vladimír Vlaanderen, J. Schuz, J. Portengen, L. Olsson, A.
s:issn
0002-9262
s:numberOfPages
9
n14:doi
10.1093/aje/kwt273
n18:organizacniJednotka
15110