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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F14%3A33149719%21RIV15-MSM-15110___
rdf:type
n7:Vysledek skos:Concept
dcterms:description
Genomes of newly emerging species restrict their gene exchange with related taxa in order to secure integrity. Hybrid sterility is one of the reproductive isolation mechanisms restricting gene flow between closely related, sexually reproducing organisms. We showed that hybrid sterility between two closely related mouse subspecies is executed by a failure of meiotic synapsis of orthologous chromosomes in F1 hybrid males. The asynapsis of orthologous chromosomes occurred in meiosis of male and female hybrids, though only males were sterile due to trans-acting male-specific hybrid sterility genes. We located one of the two major hybrid sterility genes to a 4.7 Mb interval on Chromosome X, showed that it controls male sterility by modulating the extent of meiotic asynapsis and using the inter-subspecific chromosome substitution strains we refuted the simple interpretation of dominance theory of Haldane's rule. A new working hypothesis posits male sterility of mouse inter-subsubspecific F1 hybrids as a consequence of meiotic chromosome asynapsis caused by the cis-acting mismatch between orthologous chromosomes modulated by the trans-acting hybrid male sterility genes. Hybrid sterility (HS) belongs to reproductive isolation barriers that safeguard the integrity of species in statu nascendi. Although hybrid sterility occurs almost universally among animal and plant species, most of our current knowledge comes from the classical genetic studies on Drosophila interspecific crosses or introgressions. With the house mouse subspecies Mus m. musculus and Mus m. domesticus as a model, new research tools have become available for studies of the molecular mechanisms and genetic networks underlying HS. Here we used QTL analysis and intersubspecific chromosome substitution strains to identify a 4.7 Mb critical region on Chromosome X (Chr X) harboring the Hstx2 HS locus, which causes asymmetrical spermatogenic arrest in reciprocal intersubspecific F1 hybrids. Genomes of newly emerging species restrict their gene exchange with related taxa in order to secure integrity. Hybrid sterility is one of the reproductive isolation mechanisms restricting gene flow between closely related, sexually reproducing organisms. We showed that hybrid sterility between two closely related mouse subspecies is executed by a failure of meiotic synapsis of orthologous chromosomes in F1 hybrid males. The asynapsis of orthologous chromosomes occurred in meiosis of male and female hybrids, though only males were sterile due to trans-acting male-specific hybrid sterility genes. We located one of the two major hybrid sterility genes to a 4.7 Mb interval on Chromosome X, showed that it controls male sterility by modulating the extent of meiotic asynapsis and using the inter-subspecific chromosome substitution strains we refuted the simple interpretation of dominance theory of Haldane's rule. A new working hypothesis posits male sterility of mouse inter-subsubspecific F1 hybrids as a consequence of meiotic chromosome asynapsis caused by the cis-acting mismatch between orthologous chromosomes modulated by the trans-acting hybrid male sterility genes. Hybrid sterility (HS) belongs to reproductive isolation barriers that safeguard the integrity of species in statu nascendi. Although hybrid sterility occurs almost universally among animal and plant species, most of our current knowledge comes from the classical genetic studies on Drosophila interspecific crosses or introgressions. With the house mouse subspecies Mus m. musculus and Mus m. domesticus as a model, new research tools have become available for studies of the molecular mechanisms and genetic networks underlying HS. Here we used QTL analysis and intersubspecific chromosome substitution strains to identify a 4.7 Mb critical region on Chromosome X (Chr X) harboring the Hstx2 HS locus, which causes asymmetrical spermatogenic arrest in reciprocal intersubspecific F1 hybrids.
dcterms:title
X Chromosome Control of Meiotic Chromosome Synapsis in Mouse Inter-Subspecific Hybrids X Chromosome Control of Meiotic Chromosome Synapsis in Mouse Inter-Subspecific Hybrids
skos:prefLabel
X Chromosome Control of Meiotic Chromosome Synapsis in Mouse Inter-Subspecific Hybrids X Chromosome Control of Meiotic Chromosome Synapsis in Mouse Inter-Subspecific Hybrids
skos:notation
RIV/61989592:15110/14:33149719!RIV15-MSM-15110___
n3:aktivita
n5:P n5:I
n3:aktivity
I, P(ED0030/01/01), P(ED1.1.00/02.0109), P(GA206/08/0640), P(LD11079)
n3:cisloPeriodika
2
n3:dodaniDat
n12:2015
n3:domaciTvurceVysledku
n15:9470964
n3:druhVysledku
n18:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
56431
n3:idVysledku
RIV/61989592:15110/14:33149719
n3:jazykVysledku
n14:eng
n3:klicovaSlova
INACTIVATION; MEIOSIS; MUSCULUS; DROSOPHILA; HALDANES RULE; GENETIC-ANALYSIS; RECOMBINATION HOTSPOTS; MALE-STERILITY; IN-HOUSE MICE; HISTONE H3 METHYLTRANSFERASE
n3:klicoveSlovo
n6:HISTONE%20H3%20METHYLTRANSFERASE n6:MALE-STERILITY n6:MEIOSIS n6:GENETIC-ANALYSIS n6:IN-HOUSE%20MICE n6:HALDANES%20RULE n6:INACTIVATION n6:RECOMBINATION%20HOTSPOTS n6:DROSOPHILA n6:MUSCULUS
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[AE7D04FC1160]
n3:nazevZdroje
PLoS Genetics
n3:obor
n17:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
9
n3:projekt
n13:ED0030%2F01%2F01 n13:ED1.1.00%2F02.0109 n13:LD11079 n13:GA206%2F08%2F0640
n3:rokUplatneniVysledku
n12:2014
n3:svazekPeriodika
10
n3:tvurceVysledku
Reifova, R. Forejt, J. Pialek, J. Simecek, P. Bhattacharyya, T. Gergelits, V. Mistrík, Martin Martincova, I. Gregorova, S.
n3:wos
000332021500056
s:issn
1553-7404
s:numberOfPages
15
n19:doi
10.1371/journal.pgen.1004088
n8:organizacniJednotka
15110