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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F14%3A33149240%21RIV15-MSM-15110___
rdf:type
skos:Concept n16:Vysledek
rdfs:seeAlso
http://ac.els-cdn.com/S0367326X14001464/1-s2.0-S0367326X14001464-main.pdf?_tid=185b4eca-029a-11e4-ad1d-00000aab0f01&acdnat=1404382338_018bf55bd16dd8cfe201527de84e2889
dcterms:description
Silymarin, a standardised extract of Silybum marianum (milk thistle), comprises mainly of silybin, with dehydrosilybin (DHSB), quercetin, taxifolin, silychristin and a number of other compounds which are known to possess a range of salutary effects. Indeed, there is evidence for their role in reducing tumour growth, preventing liver toxicity, and protecting a number of organs against ischemic damage. The hepatoprotective effects of silymarin, especially in preventing Amanita and alcohol intoxication induced damage to the liver, are a well established fact. Likewise, there is weighty evidence that silymarin possesses antimicrobial and anticancer activities. Additionally, it has emerged that in animal models, silymarin can protect the heart, brain, liver and kidneys against ischemia reperfusion injury, probably by preconditioning. The mechanisms of preconditioning are, in general, well studied, especially in the heart. On the other hand, the mechanism by which silymarin protects the heart from ischemia remains largely unexplored. This review, therefore, focuses on evaluating existing studies on silymarin induced cardioprotection in the context of the established mechanisms of preconditioning. Silymarin, a standardised extract of Silybum marianum (milk thistle), comprises mainly of silybin, with dehydrosilybin (DHSB), quercetin, taxifolin, silychristin and a number of other compounds which are known to possess a range of salutary effects. Indeed, there is evidence for their role in reducing tumour growth, preventing liver toxicity, and protecting a number of organs against ischemic damage. The hepatoprotective effects of silymarin, especially in preventing Amanita and alcohol intoxication induced damage to the liver, are a well established fact. Likewise, there is weighty evidence that silymarin possesses antimicrobial and anticancer activities. Additionally, it has emerged that in animal models, silymarin can protect the heart, brain, liver and kidneys against ischemia reperfusion injury, probably by preconditioning. The mechanisms of preconditioning are, in general, well studied, especially in the heart. On the other hand, the mechanism by which silymarin protects the heart from ischemia remains largely unexplored. This review, therefore, focuses on evaluating existing studies on silymarin induced cardioprotection in the context of the established mechanisms of preconditioning.
dcterms:title
Silymarin and its constituents in cardiac preconditioning Silymarin and its constituents in cardiac preconditioning
skos:prefLabel
Silymarin and its constituents in cardiac preconditioning Silymarin and its constituents in cardiac preconditioning
skos:notation
RIV/61989592:15110/14:33149240!RIV15-MSM-15110___
n4:aktivita
n7:P
n4:aktivity
P(EE2.3.30.0041), P(GAP301/11/0662)
n4:cisloPeriodika
C
n4:dodaniDat
n20:2015
n4:domaciTvurceVysledku
n5:1030957 Zholobenko, Aleksey
n4:druhVysledku
n8:J
n4:duvernostUdaju
n18:S
n4:entitaPredkladatele
n9:predkladatel
n4:idSjednocenehoVysledku
44869
n4:idVysledku
RIV/61989592:15110/14:33149240
n4:jazykVysledku
n11:eng
n4:klicovaSlova
Signalling pathways; Quercetin; Silybin; Silymarin; Preconditioning; Ischemia
n4:klicoveSlovo
n10:Silymarin n10:Preconditioning n10:Silybin n10:Signalling%20pathways n10:Ischemia n10:Quercetin
n4:kodStatuVydavatele
NL - Nizozemsko
n4:kontrolniKodProRIV
[67F84EF189B3]
n4:nazevZdroje
Fitoterapia
n4:obor
n14:CE
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
2
n4:projekt
n17:GAP301%2F11%2F0662 n17:EE2.3.30.0041
n4:rokUplatneniVysledku
n20:2014
n4:svazekPeriodika
97
n4:tvurceVysledku
Zholobenko, Aleksey Modrianský, Martin
s:issn
0367-326X
s:numberOfPages
11
n3:doi
10.1016/j.fitote.2014.05.016
n15:organizacniJednotka
15110