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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F14%3A33147593%21RIV15-MSM-15110___
rdf:type
n4:Vysledek skos:Concept
dcterms:description
Ga-68-triacetylfusarinine C (Ga-68-TAFC) and Ga-68-ferrioxamine E (Ga-68-FOXE) showed excellent targeting properties in Aspergillus fumigatus rat infection model. Here, we report on the comparison of specificity towards different microorganisms and human lung cancer cells (H1299). The in vitro uptake of Ga-68-TAFC and Ga-68-FOXE was studied in various fungal, bacterial and yeast cultures as well as in H1299 cells. The in vivo imaging was studied in fungal and bacterial rat infection and inflammation models. Ga-68-TAFC and Ga-68-FOXE showed rapid uptake in A. fumigatus cultures, significantly lower in other fungal species and almost no uptake in other microorganisms and H1299 cells, except for Ga-68-FOXE in Staphylococcus aureus. Ga-68-TAFC and Ga-68-FOXE revealed rapid uptake in the lungs of A. fumigatus-infected rats, low accumulation in sterile inflammation and no uptake in bacterial abscess. We have shown that Ga-68-FOXE and Ga-68-TAFC have high uptake in A. fumigatus both in vitro and in vivo. Ga-68-TAFC showed higher specificity, while Ga-68-FOXE showed higher sensitivity. Ga-68-triacetylfusarinine C (Ga-68-TAFC) and Ga-68-ferrioxamine E (Ga-68-FOXE) showed excellent targeting properties in Aspergillus fumigatus rat infection model. Here, we report on the comparison of specificity towards different microorganisms and human lung cancer cells (H1299). The in vitro uptake of Ga-68-TAFC and Ga-68-FOXE was studied in various fungal, bacterial and yeast cultures as well as in H1299 cells. The in vivo imaging was studied in fungal and bacterial rat infection and inflammation models. Ga-68-TAFC and Ga-68-FOXE showed rapid uptake in A. fumigatus cultures, significantly lower in other fungal species and almost no uptake in other microorganisms and H1299 cells, except for Ga-68-FOXE in Staphylococcus aureus. Ga-68-TAFC and Ga-68-FOXE revealed rapid uptake in the lungs of A. fumigatus-infected rats, low accumulation in sterile inflammation and no uptake in bacterial abscess. We have shown that Ga-68-FOXE and Ga-68-TAFC have high uptake in A. fumigatus both in vitro and in vivo. Ga-68-TAFC showed higher specificity, while Ga-68-FOXE showed higher sensitivity.
dcterms:title
68Ga-Triacetylfusarinine C and 68Ga-Ferrioxamine E for Aspergillus Infection Imaging: Uptake Specificity in Various Microorganisms 68Ga-Triacetylfusarinine C and 68Ga-Ferrioxamine E for Aspergillus Infection Imaging: Uptake Specificity in Various Microorganisms
skos:prefLabel
68Ga-Triacetylfusarinine C and 68Ga-Ferrioxamine E for Aspergillus Infection Imaging: Uptake Specificity in Various Microorganisms 68Ga-Triacetylfusarinine C and 68Ga-Ferrioxamine E for Aspergillus Infection Imaging: Uptake Specificity in Various Microorganisms
skos:notation
RIV/61989592:15110/14:33147593!RIV15-MSM-15110___
n5:aktivita
n8:P
n5:aktivity
P(ED0030/01/01)
n5:cisloPeriodika
1
n5:dodaniDat
n12:2015
n5:domaciTvurceVysledku
n13:1872931
n5:druhVysledku
n11:J
n5:duvernostUdaju
n19:S
n5:entitaPredkladatele
n17:predkladatel
n5:idSjednocenehoVysledku
58354
n5:idVysledku
RIV/61989592:15110/14:33147593
n5:jazykVysledku
n10:eng
n5:klicovaSlova
Positron emission tomography; Aspergillus fumigatus; Infection imaging; Gallium-68; Siderophores
n5:klicoveSlovo
n16:Siderophores n16:Infection%20imaging n16:Aspergillus%20fumigatus n16:Gallium-68 n16:Positron%20emission%20tomography
n5:kodStatuVydavatele
US - Spojené státy americké
n5:kontrolniKodProRIV
[F8947DFEAA52]
n5:nazevZdroje
MOLECULAR IMAGING AND BIOLOGY
n5:obor
n9:FD
n5:pocetDomacichTvurcuVysledku
1
n5:pocetTvurcuVysledku
7
n5:projekt
n15:ED0030%2F01%2F01
n5:rokUplatneniVysledku
n12:2014
n5:svazekPeriodika
16
n5:tvurceVysledku
Franssen, Gerben M Decristoforo, Clemens Laverman, Peter Petřík, Miloš Schrettl, Markus Blatzer, Michael Haas, Hubertus
n5:wos
000329793200013
s:issn
1536-1632
s:numberOfPages
7
n18:doi
10.1007/s11307-013-0654-7
n3:organizacniJednotka
15110