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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F13%3A33143925%21RIV14-MZ0-15110___
rdf:type
skos:Concept n15:Vysledek
dcterms:description
OBJECTIVE AND DESIGN: Prosthetic joint infection (PJI) is a severe complication of total joint arthroplasty (TJA). We conducted a genetic association study that investigated whether selected coding variants of the genes for Toll-like receptors (TLR)2 and TLR4 may contribute to genetic susceptibility for PJI. SUBJECTS AND METHODS: In total, 350 patients with TJA (98 with PJI/252 without PJI), and 189 unrelated healthy Czech individuals without TJA were enrolled in our study. Three missense polymorphisms of the genes encoding for TLR2 (TLR2 R753Q, rs5743708) and TLR4 (TLR4 D299G, rs4986790 and T399I, rs4986791) were genotyped by %22TaqMan%22 assay. RESULTS: The frequencies of less common variants for the investigated TLR2/TLR4 polymorphisms in healthy individuals were similar to those observed in other Caucasian populations. Importantly, the distribution of TLR2/TLR4 genotype alleles did not differ between the patients with PJI and the control groups of patients with nonseptic prostheses/healthy individuals. CONCLUSION: Our data suggest that structural genetic variants of the receptors TLR2 and TLR4 do not substantially affect the risk of prosthetic joint infection. OBJECTIVE AND DESIGN: Prosthetic joint infection (PJI) is a severe complication of total joint arthroplasty (TJA). We conducted a genetic association study that investigated whether selected coding variants of the genes for Toll-like receptors (TLR)2 and TLR4 may contribute to genetic susceptibility for PJI. SUBJECTS AND METHODS: In total, 350 patients with TJA (98 with PJI/252 without PJI), and 189 unrelated healthy Czech individuals without TJA were enrolled in our study. Three missense polymorphisms of the genes encoding for TLR2 (TLR2 R753Q, rs5743708) and TLR4 (TLR4 D299G, rs4986790 and T399I, rs4986791) were genotyped by %22TaqMan%22 assay. RESULTS: The frequencies of less common variants for the investigated TLR2/TLR4 polymorphisms in healthy individuals were similar to those observed in other Caucasian populations. Importantly, the distribution of TLR2/TLR4 genotype alleles did not differ between the patients with PJI and the control groups of patients with nonseptic prostheses/healthy individuals. CONCLUSION: Our data suggest that structural genetic variants of the receptors TLR2 and TLR4 do not substantially affect the risk of prosthetic joint infection.
dcterms:title
Coding variants of TLR2 and TLR4 genes do not substantially contribute to prosthetic joint infection Coding variants of TLR2 and TLR4 genes do not substantially contribute to prosthetic joint infection
skos:prefLabel
Coding variants of TLR2 and TLR4 genes do not substantially contribute to prosthetic joint infection Coding variants of TLR2 and TLR4 genes do not substantially contribute to prosthetic joint infection
skos:notation
RIV/61989592:15110/13:33143925!RIV14-MZ0-15110___
n15:predkladatel
n16:orjk%3A15110
n3:aktivita
n9:P
n3:aktivity
P(ED0030/01/01), P(NS10260)
n3:cisloPeriodika
5
n3:dodaniDat
n19:2014
n3:domaciTvurceVysledku
n18:2265397 n18:1507109
n3:druhVysledku
n11:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
65867
n3:idVysledku
RIV/61989592:15110/13:33143925
n3:jazykVysledku
n20:eng
n3:klicovaSlova
Total joint arthroplasty; Susceptibility; Genetic risk; Gene polymorphism; Total joint prosthesis
n3:klicoveSlovo
n5:Total%20joint%20arthroplasty n5:Total%20joint%20prosthesis n5:Gene%20polymorphism n5:Genetic%20risk n5:Susceptibility
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[16DD911A886F]
n3:nazevZdroje
Inflammation Research
n3:obor
n7:EC
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
4
n3:projekt
n8:ED0030%2F01%2F01 n8:NS10260
n3:rokUplatneniVysledku
n19:2013
n3:svazekPeriodika
62
n3:tvurceVysledku
Gallo, Jiří Mrázek, František Sťahelová, Anna Petřek, Martin
n3:wos
000317647400005
s:issn
1023-3830
s:numberOfPages
5
n10:doi
10.1007/s00011-013-0601-8
n6:organizacniJednotka
15110