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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F13%3A33140779%21RIV14-MZ0-15110___
rdf:type
skos:Concept n12:Vysledek
dcterms:description
Glycosylation abnormalities have been observed in autoimmune diseases and cancer. Here, we compare mechanisms of aberrant O-glycosylation, i.e., formation of Tn and sialyl-Tn structures, on MUC1 in breast cancer, and on IgA1 in an autoimmune disease, IgA nephropathy. The pathways of aberrant O-glycosylation, although different for MUC1 and IgA1, include dysregulation in glycosyltransferase expression, stability, and/or intracellular localization. Moreover, these aberrant glycoproteins are recognized by antibodies, although with different consequences. In breast cancer, elevated levels of antibodies recognizing aberrant MUC1 are associated with better outcome, whereas in IgA nephropathy, the antibodies recognizing aberrant IgA1 are part of the pathogenetic process. Glycosylation abnormalities have been observed in autoimmune diseases and cancer. Here, we compare mechanisms of aberrant O-glycosylation, i.e., formation of Tn and sialyl-Tn structures, on MUC1 in breast cancer, and on IgA1 in an autoimmune disease, IgA nephropathy. The pathways of aberrant O-glycosylation, although different for MUC1 and IgA1, include dysregulation in glycosyltransferase expression, stability, and/or intracellular localization. Moreover, these aberrant glycoproteins are recognized by antibodies, although with different consequences. In breast cancer, elevated levels of antibodies recognizing aberrant MUC1 are associated with better outcome, whereas in IgA nephropathy, the antibodies recognizing aberrant IgA1 are part of the pathogenetic process.
dcterms:title
Aberrant O-glycosylation and anti-glycan antibodies in an autoimmune disease IgA nephropathy and breast adenocarcinoma Aberrant O-glycosylation and anti-glycan antibodies in an autoimmune disease IgA nephropathy and breast adenocarcinoma
skos:prefLabel
Aberrant O-glycosylation and anti-glycan antibodies in an autoimmune disease IgA nephropathy and breast adenocarcinoma Aberrant O-glycosylation and anti-glycan antibodies in an autoimmune disease IgA nephropathy and breast adenocarcinoma
skos:notation
RIV/61989592:15110/13:33140779!RIV14-MZ0-15110___
n12:predkladatel
n13:orjk%3A15110
n3:aktivita
n15:P
n3:aktivity
P(GAP302/10/1055), P(LH11046), P(NT11081)
n3:cisloPeriodika
5
n3:dodaniDat
n4:2014
n3:domaciTvurceVysledku
n9:5541980 n9:1587307
n3:druhVysledku
n10:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
59217
n3:idVysledku
RIV/61989592:15110/13:33140779
n3:jazykVysledku
n19:eng
n3:klicovaSlova
IgA nephropathy
n3:klicoveSlovo
n17:IgA%20nephropathy
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[98815DAC6178]
n3:nazevZdroje
Cellular and Molecular Life Sciences
n3:obor
n14:EC
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
4
n3:projekt
n16:LH11046 n16:GAP302%2F10%2F1055 n16:NT11081
n3:rokUplatneniVysledku
n4:2013
n3:svazekPeriodika
70
n3:tvurceVysledku
Novák, Jan Raška, Milan Clausen, Henrik Stuchlová Horynová, Milada
n3:wos
000314716100005
s:issn
1420-682X
s:numberOfPages
11
n20:doi
10.1007/s00018-012-1082-6
n7:organizacniJednotka
15110