This HTML5 document contains 49 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n20http://localhost/temp/predkladatel/
n10http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n9http://linked.opendata.cz/resource/domain/vavai/subjekt/
n5http://linked.opendata.cz/ontology/domain/vavai/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n7http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F61989592%3A15110%2F12%3A33141042%21RIV13-MSM-15110___/
rdfshttp://www.w3.org/2000/01/rdf-schema#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n8http://bibframe.org/vocab/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n4http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n14http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n19http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n18http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n17http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n16http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n12http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F12%3A33141042%21RIV13-MSM-15110___
rdf:type
n5:Vysledek skos:Concept
rdfs:seeAlso
http://bloodjournal.hematologylibrary.org/content/119/13/e100.full.pdf+html
dcterms:description
Determination of clonality on the basis of assays of inactivation of genes encoded on the X chromosome has provided important insights into the origins of neoplastic diseases, helped to decipher the hierarchy of hematopoiesis, and provided a mechanism for differentiating between inherited and acquired disorders, for distinguishing between clonal and reactive acquired hematologic abnormalities and for showing cell selection in female carriers of X-linked inherited processes. The methylation status of CpG sites close to the trinucleotide repeats in exon 1 of the human androgen receptor (AR) X chromosome gene assay (HUMARA) has been used to determine clonality. This HUMARA at times indicated clonal hematopoiesis in healthy elderly women, thus precluding its applicability. We used a clonality assay based on quantitative expression of polymorphic X chromosome genes (qTCA) and found no evidence of clonal hematopoiesis in healthy nonanemic elderly persons. These data provide the molecular basis of incomplete correlation with the pattern of DNA methylation of this X chromosome AR gene locus. Determination of clonality on the basis of assays of inactivation of genes encoded on the X chromosome has provided important insights into the origins of neoplastic diseases, helped to decipher the hierarchy of hematopoiesis, and provided a mechanism for differentiating between inherited and acquired disorders, for distinguishing between clonal and reactive acquired hematologic abnormalities and for showing cell selection in female carriers of X-linked inherited processes. The methylation status of CpG sites close to the trinucleotide repeats in exon 1 of the human androgen receptor (AR) X chromosome gene assay (HUMARA) has been used to determine clonality. This HUMARA at times indicated clonal hematopoiesis in healthy elderly women, thus precluding its applicability. We used a clonality assay based on quantitative expression of polymorphic X chromosome genes (qTCA) and found no evidence of clonal hematopoiesis in healthy nonanemic elderly persons. These data provide the molecular basis of incomplete correlation with the pattern of DNA methylation of this X chromosome AR gene locus.
dcterms:title
Methylation of AR locus does not always reflect X chromosome inactivation state Methylation of AR locus does not always reflect X chromosome inactivation state
skos:prefLabel
Methylation of AR locus does not always reflect X chromosome inactivation state Methylation of AR locus does not always reflect X chromosome inactivation state
skos:notation
RIV/61989592:15110/12:33141042!RIV13-MSM-15110___
n5:predkladatel
n9:orjk%3A15110
n3:aktivita
n18:S
n3:aktivity
S
n3:cisloPeriodika
13
n3:dodaniDat
n12:2013
n3:domaciTvurceVysledku
n10:1113992
n3:druhVysledku
n16:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
149802
n3:idVysledku
RIV/61989592:15110/12:33141042
n3:jazykVysledku
n19:eng
n3:klicovaSlova
X-chromosome inactivation; TCA; HUMARA
n3:klicoveSlovo
n4:HUMARA n4:TCA n4:X-chromosome%20inactivation
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[63709E02CA31]
n3:nazevZdroje
Blood
n3:obor
n17:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
10
n3:rokUplatneniVysledku
n12:2012
n3:svazekPeriodika
119
n3:tvurceVysledku
Hickman, Kimberly Swierczek, Sabina I Cairns, Bradley Jelínek, Jaroslav Prchal, Josef T. Parker, Charles J Hammoud, Sue Agarwal, Neeraj Wilson, Andrew Piterková, Lucie
n3:wos
000302141200001
s:issn
0006-4971
s:numberOfPages
10
n8:doi
10.1182/blood-2011-11-390351
n20:organizacniJednotka
15110