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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F12%3A33140503%21RIV13-MSM-15110___
rdf:type
n11:Vysledek skos:Concept
dcterms:description
Objectives The aim of this study was to test the survival of microorganisms in eluents used for Ge-68/Ga-68 generators and for regeneration of nonradioactive Ge-68/Ga-68 generator columns after high microbial load. Nonradioactive generator columns were loaded with various microorganisms and tested to determine whether the microorganisms were proliferating or surviving in eluates of the columns. Materials and methods TiO2 columns used in a commercially available Ge-68/Ga-68 generators for absorption of Ge-68 were loaded with greater than 10(7) colony-forming units (CFU) of Staphylococcus aureus, Clostridium sporogenes, Candida albicans, Helicobacter pylori, Aspergillus niger and Deinococcus radiodurans. Columns were eluted with 0.1 N HCl under standard eluting conditions. Elutions, over a prolonged time period, were tested for endotoxins, sterility and number of CFU. Results Initial tests on the eluent (0.1 N HCl) already showed limited survival of microorganisms. Using TiO2 generator columns, even with a higher load of microorganisms no survival of any microorganism could be detected in subsequent elutions, neither in colony-forming unit assays nor in sterility testing. In addition, endotoxin tests showed no elevated levels in any of the eluent samples, even days after incubation. Conclusion The conditions used in this type of Ge-68/Ga-68 generator are highly unfavourable for survival or growth of microorganisms. The risks associated with incidental microbial contaminations during the lifetime of such a generator are therefore very low. Nucl Med Commun 33:819-823 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. Objectives The aim of this study was to test the survival of microorganisms in eluents used for Ge-68/Ga-68 generators and for regeneration of nonradioactive Ge-68/Ga-68 generator columns after high microbial load. Nonradioactive generator columns were loaded with various microorganisms and tested to determine whether the microorganisms were proliferating or surviving in eluates of the columns. Materials and methods TiO2 columns used in a commercially available Ge-68/Ga-68 generators for absorption of Ge-68 were loaded with greater than 10(7) colony-forming units (CFU) of Staphylococcus aureus, Clostridium sporogenes, Candida albicans, Helicobacter pylori, Aspergillus niger and Deinococcus radiodurans. Columns were eluted with 0.1 N HCl under standard eluting conditions. Elutions, over a prolonged time period, were tested for endotoxins, sterility and number of CFU. Results Initial tests on the eluent (0.1 N HCl) already showed limited survival of microorganisms. Using TiO2 generator columns, even with a higher load of microorganisms no survival of any microorganism could be detected in subsequent elutions, neither in colony-forming unit assays nor in sterility testing. In addition, endotoxin tests showed no elevated levels in any of the eluent samples, even days after incubation. Conclusion The conditions used in this type of Ge-68/Ga-68 generator are highly unfavourable for survival or growth of microorganisms. The risks associated with incidental microbial contaminations during the lifetime of such a generator are therefore very low. Nucl Med Commun 33:819-823 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
dcterms:title
Microbial challenge tests on nonradioactive TiO2-based 68Ge/68Ga generator columns Microbial challenge tests on nonradioactive TiO2-based 68Ge/68Ga generator columns
skos:prefLabel
Microbial challenge tests on nonradioactive TiO2-based 68Ge/68Ga generator columns Microbial challenge tests on nonradioactive TiO2-based 68Ge/68Ga generator columns
skos:notation
RIV/61989592:15110/12:33140503!RIV13-MSM-15110___
n11:predkladatel
n19:orjk%3A15110
n3:aktivita
n15:P
n3:aktivity
P(ED0030/01/01)
n3:cisloPeriodika
8
n3:dodaniDat
n9:2013
n3:domaciTvurceVysledku
n17:1872931
n3:druhVysledku
n16:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
150305
n3:idVysledku
RIV/61989592:15110/12:33140503
n3:jazykVysledku
n10:eng
n3:klicovaSlova
microorganisms; generator column eluate; Ge-68/Ga-68 generator
n3:klicoveSlovo
n6:generator%20column%20eluate n6:microorganisms n6:Ge-68%2FGa-68%20generator
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[D2DFE3DDE6D5]
n3:nazevZdroje
Nuclear Medicine Communications
n3:obor
n5:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:projekt
n20:ED0030%2F01%2F01
n3:rokUplatneniVysledku
n9:2012
n3:svazekPeriodika
33
n3:tvurceVysledku
Schuessele, Andrea Becker, Dirk Petřík, Miloš Lass-Flörl, Cornelia Perkhofer, Susanne Decristoforo, Clemens
n3:wos
000306584300004
s:issn
0143-3636
s:numberOfPages
5
n13:doi
10.1097/MNM.0b013e3283543323
n7:organizacniJednotka
15110