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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F12%3A33139127%21RIV13-GA0-15110___
rdf:type
n11:Vysledek skos:Concept
dcterms:description
The review deals with the probable etiology, diagnostics, classification, most likely causative drugs, risk factors and disease course of drug-induced cholestasis. Cholestatic and mixed forms of drug-induced liver injury (DILI) account for nearly half of all reported cases. Medications are probably responsible for 2 - 5 % of cases of jaundice requiring hospital admission; moreover, all forms of DILI are currently the most common adverse drug reaction resulting in withdrawal of new drugs from clinical research. Cholestatic syndromes caused by drugs can be divided into acute (bland cholestasis, cholestatic hepatitis and cholangiolitis) and, less frequent, chronic (vanishing bile duct syndrome and extrahepatic biliary obstruction). The etiology seems to be mostly idiosyncratic, with a supposed genetic predisposition. Bile salt export pump (BSEP) is known to be subject to drug inhibition in susceptible patients. Besides rare mutations that have been linked to drug-induced cholestasis, the common p.V444A polymorphism of BSEP, DRB1*1501 HLA class II haplotype and homozygosity for GSTM1 null and/or GSTT1 null alleles have been identified as a potential risk factors. No specific tests are available for establishing drug etiology of cholestasis; therefore causality assessment is performed in the same way as in other adverse drug reactions. Several structured causality assessment methods for DILI have also been proposed, e.g. RUCAM, CIOMS score etc. Drugs known to cause cholestatic syndromes include various antibiotics, oral contraceptives, oral antidiabetics and numerous other drugs including herbal medicines. The review deals with the probable etiology, diagnostics, classification, most likely causative drugs, risk factors and disease course of drug-induced cholestasis. Cholestatic and mixed forms of drug-induced liver injury (DILI) account for nearly half of all reported cases. Medications are probably responsible for 2 - 5 % of cases of jaundice requiring hospital admission; moreover, all forms of DILI are currently the most common adverse drug reaction resulting in withdrawal of new drugs from clinical research. Cholestatic syndromes caused by drugs can be divided into acute (bland cholestasis, cholestatic hepatitis and cholangiolitis) and, less frequent, chronic (vanishing bile duct syndrome and extrahepatic biliary obstruction). The etiology seems to be mostly idiosyncratic, with a supposed genetic predisposition. Bile salt export pump (BSEP) is known to be subject to drug inhibition in susceptible patients. Besides rare mutations that have been linked to drug-induced cholestasis, the common p.V444A polymorphism of BSEP, DRB1*1501 HLA class II haplotype and homozygosity for GSTM1 null and/or GSTT1 null alleles have been identified as a potential risk factors. No specific tests are available for establishing drug etiology of cholestasis; therefore causality assessment is performed in the same way as in other adverse drug reactions. Several structured causality assessment methods for DILI have also been proposed, e.g. RUCAM, CIOMS score etc. Drugs known to cause cholestatic syndromes include various antibiotics, oral contraceptives, oral antidiabetics and numerous other drugs including herbal medicines.
dcterms:title
Drug-induced cholestatic liver injury Drug-induced cholestatic liver injury
skos:prefLabel
Drug-induced cholestatic liver injury Drug-induced cholestatic liver injury
skos:notation
RIV/61989592:15110/12:33139127!RIV13-GA0-15110___
n11:predkladatel
n16:orjk%3A15110
n3:aktivita
n4:S n4:P
n3:aktivity
P(GBP303/12/G163), S
n3:dodaniDat
n12:2013
n3:domaciTvurceVysledku
n7:7247621 n7:8644500 n7:3719979
n3:druhVysledku
n21:C
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
132223
n3:idVysledku
RIV/61989592:15110/12:33139127
n3:jazykVysledku
n19:eng
n3:klicovaSlova
adversedrug reaction; cholestatic hepatitis; drug-induced liver injury; Cholestatis
n3:klicoveSlovo
n6:cholestatic%20hepatitis n6:adversedrug%20reaction n6:drug-induced%20liver%20injury n6:Cholestatis
n3:kontrolniKodProRIV
[0F3BAB7E0576]
n3:mistoVydani
New York
n3:nazevEdiceCisloSvazku
Cell Biology Research Progress
n3:nazevZdroje
Bilirubin Chemistry, Regulation and Disorder
n3:obor
n10:FR
n3:pocetDomacichTvurcuVysledku
3
n3:pocetStranKnihy
323
n3:pocetTvurcuVysledku
3
n3:projekt
n18:GBP303%2F12%2FG163
n3:rokUplatneniVysledku
n12:2012
n3:tvurceVysledku
Procházka, Vlastimil Krystyník, Ondřej Urbánek, Karel
s:numberOfPages
15
n20:hasPublisher
Nova Science Publishers, Inc.
n17:isbn
978-1-62100-911-5
n15:organizacniJednotka
15110