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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F12%3A33138480%21RIV13-MSM-15110___
rdf:type
skos:Concept n5:Vysledek
dcterms:description
In 2008, the World Health Organization (WHO) revised its classification of hematopoietic neoplasms and new %22acute myeloid leukemia with myelodysplasia-related changes (AML-MCR)%22 was defined as !AML arising from a previous MDS or MDS/MPN, AML with an MDS-related cytogenetic abnormality, and/or AML-MLD changes, mainly with a complex karyotype! (1). Myelodyplastic syndrome (MDS)-related chromosomal changes involve mainly aberrations of chromosomes 5, 7, and a complex karyotype. The change from ploidy to tetraploidy (4n) is a rare chromosomal abnormality in AML, and only a few cases have been described in the literature (2,3). Despite its rarity in AML, tetraploidization can initiate chromosomal instability (CIN) and promote cell transformation (4,5). Presented here is a case of a 52-year-old male with an initial diagnosis of AML-MRC with tetraploid clones detected in his bone marrow. FISH analysis revealed a large deleted derivative chromosome 5 within a complex caryotype. To the best of our knowledge, such findings in AML-MRC have not yet been reported in the literature. In 2008, the World Health Organization (WHO) revised its classification of hematopoietic neoplasms and new %22acute myeloid leukemia with myelodysplasia-related changes (AML-MCR)%22 was defined as !AML arising from a previous MDS or MDS/MPN, AML with an MDS-related cytogenetic abnormality, and/or AML-MLD changes, mainly with a complex karyotype! (1). Myelodyplastic syndrome (MDS)-related chromosomal changes involve mainly aberrations of chromosomes 5, 7, and a complex karyotype. The change from ploidy to tetraploidy (4n) is a rare chromosomal abnormality in AML, and only a few cases have been described in the literature (2,3). Despite its rarity in AML, tetraploidization can initiate chromosomal instability (CIN) and promote cell transformation (4,5). Presented here is a case of a 52-year-old male with an initial diagnosis of AML-MRC with tetraploid clones detected in his bone marrow. FISH analysis revealed a large deleted derivative chromosome 5 within a complex caryotype. To the best of our knowledge, such findings in AML-MRC have not yet been reported in the literature.
dcterms:title
Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MCR) Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MCR)
skos:prefLabel
Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MCR) Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MCR)
skos:notation
RIV/61989592:15110/12:33138480!RIV13-MSM-15110___
n5:predkladatel
n6:orjk%3A15110
n3:aktivita
n16:Z n16:S
n3:aktivity
S, Z(MSM6198959205)
n3:cisloPeriodika
4
n3:dodaniDat
n4:2013
n3:domaciTvurceVysledku
n11:8478325 n11:7479220 n11:7112084 n11:3790061 n11:1672665 n11:3461904 n11:9065393 n11:6432417 n11:8141975
n3:druhVysledku
n18:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
164118
n3:idVysledku
RIV/61989592:15110/12:33138480
n3:jazykVysledku
n19:eng
n3:klicovaSlova
FISH analysis; chromosomal changes; myelodysplastic syndrome
n3:klicoveSlovo
n10:FISH%20analysis n10:chromosomal%20changes n10:myelodysplastic%20syndrome
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[A07EE1E9731C]
n3:nazevZdroje
Leukemia Research
n3:obor
n9:FD
n3:pocetDomacichTvurcuVysledku
9
n3:pocetTvurcuVysledku
9
n3:rokUplatneniVysledku
n4:2012
n3:svazekPeriodika
36
n3:tvurceVysledku
Pikalová, Zuzana Mičková, Pavla Hubáček, Jaromír Indrák, Karel Papajík, Tomáš Nedomová, Radka Holzerová, Milena Katrincsáková, Beáta Jarošová, Marie
n3:zamer
n14:MSM6198959205
s:issn
0145-2126
s:numberOfPages
3
n17:doi
10.1016/j.leukres.2011.12.014
n20:organizacniJednotka
15110