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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F11%3A33118601%21RIV14-GA0-15110___
rdf:type
skos:Concept n7:Vysledek
dcterms:description
Shock waves, pressure waves manifested as a sharp increase in positive pressure followed by a decrease and the negative part of the wave, are not only used to treat concrements in medicine. Recently, research has been focused on the possibility of their use for damaging the tumour tissue. In contrast to concrements, which are different from the surrounding tissue by their acoustic impedance, the tumour tissue has the same acoustic impedance as the surrounding soft tissue. Therefore, we have developed a new source of shock waves, which is based on the principle of multichannel discharge. This new source generates two successive shock waves (tandem shock waves). The first shock creates acoustic non-homogeneity and cavitations in the tissue, and the second shock is damped in it. In this work we demonstrated the effect of tandem shock waves on the muscle tissue in depth. The damage is shown on the images from the magnetic resonance imaging and histological sections. In the further part of the experiment, we investigated the in vivo effects of tandem shock waves in combination with Photosan and cisplatin on the tumour tissue. The application of tandem shock waves resulted in the inhibition of tumour growth, compared with controls, in both parts of the experiment. The largest inhibition effect was observed in the groups of tandem shock waves combined with Photosan and in the second part with cisplatin. Shock waves, pressure waves manifested as a sharp increase in positive pressure followed by a decrease and the negative part of the wave, are not only used to treat concrements in medicine. Recently, research has been focused on the possibility of their use for damaging the tumour tissue. In contrast to concrements, which are different from the surrounding tissue by their acoustic impedance, the tumour tissue has the same acoustic impedance as the surrounding soft tissue. Therefore, we have developed a new source of shock waves, which is based on the principle of multichannel discharge. This new source generates two successive shock waves (tandem shock waves). The first shock creates acoustic non-homogeneity and cavitations in the tissue, and the second shock is damped in it. In this work we demonstrated the effect of tandem shock waves on the muscle tissue in depth. The damage is shown on the images from the magnetic resonance imaging and histological sections. In the further part of the experiment, we investigated the in vivo effects of tandem shock waves in combination with Photosan and cisplatin on the tumour tissue. The application of tandem shock waves resulted in the inhibition of tumour growth, compared with controls, in both parts of the experiment. The largest inhibition effect was observed in the groups of tandem shock waves combined with Photosan and in the second part with cisplatin.
dcterms:title
Effects of Tandem Shock Waves Combined with Photosan and Cytostatics on the Growth of Tumours Effects of Tandem Shock Waves Combined with Photosan and Cytostatics on the Growth of Tumours
skos:prefLabel
Effects of Tandem Shock Waves Combined with Photosan and Cytostatics on the Growth of Tumours Effects of Tandem Shock Waves Combined with Photosan and Cytostatics on the Growth of Tumours
skos:notation
RIV/61989592:15110/11:33118601!RIV14-GA0-15110___
n7:predkladatel
n8:orjk%3A15110
n4:aktivita
n17:I n17:P n17:Z
n4:aktivity
I, P(GA202/09/1151), Z(MSM0021620808)
n4:cisloPeriodika
6
n4:dodaniDat
n10:2014
n4:domaciTvurceVysledku
n18:4906403
n4:druhVysledku
n19:J
n4:duvernostUdaju
n20:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
196683
n4:idVysledku
RIV/61989592:15110/11:33118601
n4:jazykVysledku
n13:eng
n4:klicovaSlova
extracorporeal lithotripsy; tumour growth; tandem shock waves; cavitations; focused shock waves; electrical discharges in water
n4:klicoveSlovo
n9:extracorporeal%20lithotripsy n9:electrical%20discharges%20in%20water n9:tandem%20shock%20waves n9:tumour%20growth n9:cavitations n9:focused%20shock%20waves
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[6EF594F3E690]
n4:nazevZdroje
Folia Biologica
n4:obor
n12:BO
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
7
n4:projekt
n11:GA202%2F09%2F1151
n4:rokUplatneniVysledku
n10:2011
n4:svazekPeriodika
57
n4:tvurceVysledku
Poučková, Pavla Kolářová, Hana Zadinová, Marie Zeman, Jan Lukeš, Petr Beneš, Jiří Šunka, Pavel
n4:wos
000299144400005
n4:zamer
n15:MSM0021620808
s:issn
0015-5500
s:numberOfPages
6
n6:organizacniJednotka
15110