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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F11%3A33116438%21RIV12-MSM-15110___
rdf:type
skos:Concept n7:Vysledek
dcterms:description
The aims of this prospective study were to determine the prevalence of clinically silent rejection changes and of nephrotoxicity of calcineurin inhibitors among repeated protocol biopsies of transplanted kidneys and to assess their impacts on chronic graft function and damage at the end of 1 year. Subclinical rejection and toxic changes among a significant proportion of grafts are associated with progression of chronic changes already over the first year following transplantation. Hence they represent independent risk factors for the development of irreversible graft damage. Protocol biopsy seems to be an important method to monitor immunosuppressive therapy. The aims of this prospective study were to determine the prevalence of clinically silent rejection changes and of nephrotoxicity of calcineurin inhibitors among repeated protocol biopsies of transplanted kidneys and to assess their impacts on chronic graft function and damage at the end of 1 year. Subclinical rejection and toxic changes among a significant proportion of grafts are associated with progression of chronic changes already over the first year following transplantation. Hence they represent independent risk factors for the development of irreversible graft damage. Protocol biopsy seems to be an important method to monitor immunosuppressive therapy.
dcterms:title
Protocol biopsy of a transplanted kidney as a tool for monitoring adequacy of immunosupressive therapy: 10 years of experience from a single transplant center Protocol biopsy of a transplanted kidney as a tool for monitoring adequacy of immunosupressive therapy: 10 years of experience from a single transplant center
skos:prefLabel
Protocol biopsy of a transplanted kidney as a tool for monitoring adequacy of immunosupressive therapy: 10 years of experience from a single transplant center Protocol biopsy of a transplanted kidney as a tool for monitoring adequacy of immunosupressive therapy: 10 years of experience from a single transplant center
skos:notation
RIV/61989592:15110/11:33116438!RIV12-MSM-15110___
n7:predkladatel
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n3:aktivita
n15:I
n3:aktivity
I
n3:cisloPeriodika
5
n3:dodaniDat
n4:2012
n3:domaciTvurceVysledku
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n14:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
224854
n3:idVysledku
RIV/61989592:15110/11:33116438
n3:jazykVysledku
n17:eng
n3:klicovaSlova
subclinical rejection; subclinical nephrotoxicity; renal graft damage; protocol biopsy; kidney transplantation; calcineurin inhibitors
n3:klicoveSlovo
n11:calcineurin%20inhibitors n11:protocol%20biopsy n11:kidney%20transplantation n11:subclinical%20nephrotoxicity n11:renal%20graft%20damage n11:subclinical%20rejection
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[9E073168DF04]
n3:nazevZdroje
Transplantation Proceedings
n3:obor
n18:FE
n3:pocetDomacichTvurcuVysledku
10
n3:pocetTvurcuVysledku
11
n3:rokUplatneniVysledku
n4:2011
n3:svazekPeriodika
43
n3:tvurceVysledku
Tichý, Tomáš Štrebl, Pavel Hrubý, Miroslav Horák, Pavel Horčička, Vladko Žamboch, Kamil Krejčí, Karel Al-Gabri, Sadek Bachleda, Petr Ciferská, Hana Zadražil, Josef
s:issn
0041-1345
s:numberOfPages
7
n16:organizacniJednotka
15110