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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F11%3A10223080%21RIV12-MSM-15110___
rdf:type
skos:Concept n12:Vysledek
dcterms:description
Aberrant neurodevelopment contributes to the etiology of schizophrenia. This study aimed to investigate the potential association of netrin G1 (NTNG1) rs628117 and brain-derived neurotrophic factor (BDNF)Val66Met(rs6265) genetic polymorphisms with susceptibility to schizophrenia. One hundred three Armenian patients with schizophrenia and 105 healthy control subjects were genotyped by polymerase chain reaction with sequence-specific primers. Whereas the NTNG1 rs628117 genotypes were equally distributed in the groups, the carriers of the less common BDNF 66Met allele were overrepresented among patients with schizophrenia when compared with healthy controls (55% vs 35%, odds ratio=2.28, 95% confidence interval 1.14-1.98, p(corrected)=0.006). Furthermore, the 66Met/Met genotype correlated with earlier disease onset (p=0.024). In conclusion, our single-cohort study nominates the BDNF 66Met allele as a risk factor for schizophrenia in an Armenian population. This must be confirmed in other Armenian cohorts. Aberrant neurodevelopment contributes to the etiology of schizophrenia. This study aimed to investigate the potential association of netrin G1 (NTNG1) rs628117 and brain-derived neurotrophic factor (BDNF)Val66Met(rs6265) genetic polymorphisms with susceptibility to schizophrenia. One hundred three Armenian patients with schizophrenia and 105 healthy control subjects were genotyped by polymerase chain reaction with sequence-specific primers. Whereas the NTNG1 rs628117 genotypes were equally distributed in the groups, the carriers of the less common BDNF 66Met allele were overrepresented among patients with schizophrenia when compared with healthy controls (55% vs 35%, odds ratio=2.28, 95% confidence interval 1.14-1.98, p(corrected)=0.006). Furthermore, the 66Met/Met genotype correlated with earlier disease onset (p=0.024). In conclusion, our single-cohort study nominates the BDNF 66Met allele as a risk factor for schizophrenia in an Armenian population. This must be confirmed in other Armenian cohorts.
dcterms:title
Functional variants of the genes involved in neurodevelopment and susceptibility to schizophrenia in Armenian population Functional variants of the genes involved in neurodevelopment and susceptibility to schizophrenia in Armenian population
skos:prefLabel
Functional variants of the genes involved in neurodevelopment and susceptibility to schizophrenia in Armenian population Functional variants of the genes involved in neurodevelopment and susceptibility to schizophrenia in Armenian population
skos:notation
RIV/61989592:15110/11:10223080!RIV12-MSM-15110___
n12:predkladatel
n13:orjk%3A15110
n3:aktivita
n14:S n14:Z
n3:aktivity
S, Z(MSM6198959205)
n3:cisloPeriodika
9
n3:dodaniDat
n8:2012
n3:domaciTvurceVysledku
n4:6090788 n4:2265397
n3:druhVysledku
n16:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
200537
n3:idVysledku
RIV/61989592:15110/11:10223080
n3:jazykVysledku
n10:eng
n3:klicovaSlova
single nucleotide polymorphisms; netrin G1; brain derived neurotrophic factor; neurodevelopment; schizophrenia
n3:klicoveSlovo
n15:neurodevelopment n15:schizophrenia n15:netrin%20G1 n15:single%20nucleotide%20polymorphisms n15:brain%20derived%20neurotrophic%20factor
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[E8DBB1788FC2]
n3:nazevZdroje
Human Immunology
n3:obor
n17:EC
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n8:2011
n3:svazekPeriodika
72
n3:tvurceVysledku
Boyajyan, Anna Zakharyan, Roksana Gevorgyan, Anaida Petřek, Martin Mrázek, František Arakelyan, Arsen
n3:zamer
n18:MSM6198959205
s:issn
0198-8859
s:numberOfPages
3
n7:organizacniJednotka
15110