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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F11%3A10222123%21RIV12-MSM-15110___
rdf:type
skos:Concept n11:Vysledek
dcterms:description
UV light is known to be implicated in several skin diseases. Through low molecular weight mediators, %22non-skin%22 tissues can also be affected. Female SKH-1 mice were exposed to a single dose of UVB (200, 800 mJ/cm(2)) or UVA (10, 20 J/cm(2)). Effects on haematological parameters, activity and/or expression of antioxidant enzymes, level of GSH, oxidative damage markers were analysed in blood, liver and skin. The blood count showed a significant increase in leukocyte number and reduction of platelets 4 h after UVA and UVB irradiation, which disappeared within 24 h except for the higher UVA dose. Changes in activity of catalase (CAT) and superoxide dismutase (SOD) and level of GSH and lipid peroxidation products were found in skin, erythrocytes and liver. Expression of CAT, SOD, glutathione transferase, nicotinamide adenine dinucleotide (phosphate) quinone oxidoreductase and hem oxygenase-1 in skin was affected after UVA and UVB radiation. Increase in carbonylated proteins was found in plasma and skin. UV light is known to be implicated in several skin diseases. Through low molecular weight mediators, %22non-skin%22 tissues can also be affected. Female SKH-1 mice were exposed to a single dose of UVB (200, 800 mJ/cm(2)) or UVA (10, 20 J/cm(2)). Effects on haematological parameters, activity and/or expression of antioxidant enzymes, level of GSH, oxidative damage markers were analysed in blood, liver and skin. The blood count showed a significant increase in leukocyte number and reduction of platelets 4 h after UVA and UVB irradiation, which disappeared within 24 h except for the higher UVA dose. Changes in activity of catalase (CAT) and superoxide dismutase (SOD) and level of GSH and lipid peroxidation products were found in skin, erythrocytes and liver. Expression of CAT, SOD, glutathione transferase, nicotinamide adenine dinucleotide (phosphate) quinone oxidoreductase and hem oxygenase-1 in skin was affected after UVA and UVB radiation. Increase in carbonylated proteins was found in plasma and skin.
dcterms:title
Acute exposure to solar simulated ultraviolet radiation affects oxidative stress-related biomarkers in skin, liver and blood of hairless mice Acute exposure to solar simulated ultraviolet radiation affects oxidative stress-related biomarkers in skin, liver and blood of hairless mice
skos:prefLabel
Acute exposure to solar simulated ultraviolet radiation affects oxidative stress-related biomarkers in skin, liver and blood of hairless mice Acute exposure to solar simulated ultraviolet radiation affects oxidative stress-related biomarkers in skin, liver and blood of hairless mice
skos:notation
RIV/61989592:15110/11:10222123!RIV12-MSM-15110___
n11:predkladatel
n12:orjk%3A15110
n3:aktivita
n13:Z n13:P
n3:aktivity
P(GP303/07/P314), Z(MSM6198959216)
n3:cisloPeriodika
4
n3:dodaniDat
n10:2012
n3:domaciTvurceVysledku
n7:2706571 n7:2514559 n7:4594266 n7:2326868 n7:2600285 n7:5752450
n3:druhVysledku
n20:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
184535
n3:idVysledku
RIV/61989592:15110/11:10222123
n3:jazykVysledku
n18:eng
n3:klicovaSlova
oxidative stress; hairless mouse; acute toxicity; UVA; UVB
n3:klicoveSlovo
n15:oxidative%20stress n15:hairless%20mouse n15:UVA n15:UVB n15:acute%20toxicity
n3:kodStatuVydavatele
JP - Japonsko
n3:kontrolniKodProRIV
[A09BD7FE8F8F]
n3:nazevZdroje
Biological & Pharmaceutical Bulletin
n3:obor
n16:CE
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
6
n3:projekt
n17:GP303%2F07%2FP314
n3:rokUplatneniVysledku
n10:2011
n3:svazekPeriodika
34
n3:tvurceVysledku
Ulrichová, Jitka Doležal, Dalibor Šianská, Jarmila Galandáková, Adéla Rajnochová Svobodová, Alena Vostálová, Jitka
n3:zamer
n14:MSM6198959216
s:issn
0918-6158
s:numberOfPages
9
n5:organizacniJednotka
15110