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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F10%3A33118890%21RIV12-MSM-15110___
rdf:type
n18:Vysledek skos:Concept
dcterms:description
New oleanane alcohols and their acetates were prepared using classical reductive reagents (LiAlH4, NaBH4, and B2H6-DMS). In this research, we also studied the influence of these reagents on the stereoselectivity of reduction. All compounds prepared were fully characterized by 1H and 13C NMR spectra, IR spectra, MS, and elemental analysis. These products were tested for cytotoxic activity against T-lymphoblastic leukemia (CEM), human erythromyeloblastoid leukemia (K562), and human melanoma (SK-MEL1) cell lines. One of the compounds prepared exhibits significant cytotoxic activity against the mesenchymal type of cancer cell lines. New oleanane alcohols and their acetates were prepared using classical reductive reagents (LiAlH4, NaBH4, and B2H6-DMS). In this research, we also studied the influence of these reagents on the stereoselectivity of reduction. All compounds prepared were fully characterized by 1H and 13C NMR spectra, IR spectra, MS, and elemental analysis. These products were tested for cytotoxic activity against T-lymphoblastic leukemia (CEM), human erythromyeloblastoid leukemia (K562), and human melanoma (SK-MEL1) cell lines. One of the compounds prepared exhibits significant cytotoxic activity against the mesenchymal type of cancer cell lines.
dcterms:title
Preparation of new 18-alpha-oleanane alcohols: synthesis, characterization and cytotoxic activity Preparation of new 18-alpha-oleanane alcohols: synthesis, characterization and cytotoxic activity
skos:prefLabel
Preparation of new 18-alpha-oleanane alcohols: synthesis, characterization and cytotoxic activity Preparation of new 18-alpha-oleanane alcohols: synthesis, characterization and cytotoxic activity
skos:notation
RIV/61989592:15110/10:33118890!RIV12-MSM-15110___
n3:aktivita
n17:Z n17:S n17:P
n3:aktivity
P(GA305/09/1216), P(GP203/05/P025), P(KAN200200651), S, Z(AV0Z40550506), Z(MSM6198959216)
n3:cisloPeriodika
2
n3:dodaniDat
n16:2012
n3:domaciTvurceVysledku
n10:7608543 n10:8434573
n3:druhVysledku
n19:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
281376
n3:idVysledku
RIV/61989592:15110/10:33118890
n3:jazykVysledku
n6:eng
n3:klicovaSlova
cytotoxicity; configuration; alcohol; ketone; hydride; reduction
n3:klicoveSlovo
n5:configuration n5:hydride n5:cytotoxicity n5:ketone n5:alcohol n5:reduction
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[CC5F90407590]
n3:nazevZdroje
Monatshefte für Chemie
n3:obor
n7:CC
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
4
n3:projekt
n14:GA305%2F09%2F1216 n14:GP203%2F05%2FP025 n14:KAN200200651
n3:rokUplatneniVysledku
n16:2010
n3:svazekPeriodika
141
n3:tvurceVysledku
Hajdúch, Marián Kvasnica, M. Šarek, Jan Rudovská, I.
n3:zamer
n4:MSM6198959216 n4:AV0Z40550506
s:issn
0026-9247
s:numberOfPages
12
n12:organizacniJednotka
15110