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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F10%3A33117968%21RIV13-MZ0-15110___
rdf:type
skos:Concept n15:Vysledek
dcterms:description
The aim was to monitor the changes in hemocoagulation parameters in acute ischemic stroke (AIS) patients after sono-thrombolysis of the occluded middle cerebral artery using a duplex transcranial probe with 2.0-MHz frequency in Doppler mode. Sixteen AIS patients indicated for intravenous thrombolysis (IVT) (8 males; mean age 68.3 +/- 7.1 y) and 16 AIS patients contraindicated for IVT (11 males; mean age 67.9 +/- 7.9 y) were randomized for sono-thrombolysis (8 + 8 patients) or standard treatment (control group) (8 + 8 patients). The significant decrease of plasminogen activator inhibitor-1, plasminogen and alpha-2-antiplasmin activity by a mean of 60, 32 and 24%, respectively, and the increase of tissue plasminogen activator by a mean of 56% was found after sono-thrombolysis when compared with control group (p { 0.0125); these changes were more evident in patients treated with a combination of sono-thrombolysis and IVT (79, 38, 50 and 82%, respectively) than in patients treated by sono-thrombolysis alone (34, 13, 17 and 30%, respectively). The aim was to monitor the changes in hemocoagulation parameters in acute ischemic stroke (AIS) patients after sono-thrombolysis of the occluded middle cerebral artery using a duplex transcranial probe with 2.0-MHz frequency in Doppler mode. Sixteen AIS patients indicated for intravenous thrombolysis (IVT) (8 males; mean age 68.3 +/- 7.1 y) and 16 AIS patients contraindicated for IVT (11 males; mean age 67.9 +/- 7.9 y) were randomized for sono-thrombolysis (8 + 8 patients) or standard treatment (control group) (8 + 8 patients). The significant decrease of plasminogen activator inhibitor-1, plasminogen and alpha-2-antiplasmin activity by a mean of 60, 32 and 24%, respectively, and the increase of tissue plasminogen activator by a mean of 56% was found after sono-thrombolysis when compared with control group (p { 0.0125); these changes were more evident in patients treated with a combination of sono-thrombolysis and IVT (79, 38, 50 and 82%, respectively) than in patients treated by sono-thrombolysis alone (34, 13, 17 and 30%, respectively).
dcterms:title
Changes in hemocoagulation in acute stroke patients after one-hour sono-thrombolysis using a diagnostic probe. Changes in hemocoagulation in acute stroke patients after one-hour sono-thrombolysis using a diagnostic probe.
skos:prefLabel
Changes in hemocoagulation in acute stroke patients after one-hour sono-thrombolysis using a diagnostic probe. Changes in hemocoagulation in acute stroke patients after one-hour sono-thrombolysis using a diagnostic probe.
skos:notation
RIV/61989592:15110/10:33117968!RIV13-MZ0-15110___
n3:aktivita
n11:V n11:P
n3:aktivity
P(NR9487), V
n3:cisloPeriodika
7
n3:dodaniDat
n12:2013
n3:domaciTvurceVysledku
n8:3054691 n8:6412637 n8:3092488 n8:6251145 n8:9723668
n3:druhVysledku
n14:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
250294
n3:idVysledku
RIV/61989592:15110/10:33117968
n3:jazykVysledku
n18:eng
n3:klicovaSlova
sono-thrombolysis; acute stroke; hemocoagulation
n3:klicoveSlovo
n7:sono-thrombolysis n7:acute%20stroke n7:hemocoagulation
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[70AF2ADDE11A]
n3:nazevZdroje
Ultrasound in Medicine and Biology
n3:obor
n13:FH
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
11
n3:projekt
n16:NR9487
n3:rokUplatneniVysledku
n12:2010
n3:svazekPeriodika
36
n3:tvurceVysledku
Školoudík, David Langová, Kateřina Roubec, Martin Kaňovský, Petr Bardoň, Petr Šaňák, Daniel Zapletal, Ondřej Herzig, Roman Fadrná, Táňa Blatný, J. Bar, Michal
n3:wos
000279066000002
s:issn
0301-5629
s:numberOfPages
8
n19:doi
10.1016/j.ultrasmedbio.2010.04.010
n17:organizacniJednotka
15110