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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F10%3A10223403%21RIV14-MZ0-15110___
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Objective: Parkinson's disease (PD) is a chronic, progressive, neurodegenerative disease with a multifactorial etiology. Protein accumulation is speculated by some to play a prominent role in the pathogenesis of PD. The severity of neurodegeneration should correlate with cerebrospinal fluid (CSF) levels of these neurodegenerative markers (NDMs). The aims of the study were to assess the CSF levels of tau protein, beta-amyloid(1-42), cystatin C and clusterin in patients suffering from PD and in a control group, to compare the CSF levels between the two groups and to correlate them to PD duration. Objective: Parkinson's disease (PD) is a chronic, progressive, neurodegenerative disease with a multifactorial etiology. Protein accumulation is speculated by some to play a prominent role in the pathogenesis of PD. The severity of neurodegeneration should correlate with cerebrospinal fluid (CSF) levels of these neurodegenerative markers (NDMs). The aims of the study were to assess the CSF levels of tau protein, beta-amyloid(1-42), cystatin C and clusterin in patients suffering from PD and in a control group, to compare the CSF levels between the two groups and to correlate them to PD duration.
dcterms:title
CSF markers of neurodegeneration in Parkinson's disease CSF markers of neurodegeneration in Parkinson's disease
skos:prefLabel
CSF markers of neurodegeneration in Parkinson's disease CSF markers of neurodegeneration in Parkinson's disease
skos:notation
RIV/61989592:15110/10:10223403!RIV14-MZ0-15110___
n3:aktivita
n14:S n14:P n14:I n14:V
n3:aktivity
I, P(NF7480), S, V
n3:cisloPeriodika
117
n3:dodaniDat
n13:2014
n3:domaciTvurceVysledku
n4:6627471 n4:5477204 n4:6251145 n4:2581957 n4:3795837 n4:7240961 n4:8525455
n3:druhVysledku
n12:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
252464
n3:idVysledku
RIV/61989592:15110/10:10223403
n3:jazykVysledku
n11:eng
n3:klicovaSlova
neurodegeneration; CSF; clusterin; tau protein; Parkinson's disease
n3:klicoveSlovo
n8:tau%20protein n8:CSF n8:clusterin n8:Parkinson%27s%20disease n8:neurodegeneration
n3:kodStatuVydavatele
AT - Rakouská republika
n3:kontrolniKodProRIV
[0B8DA700B4A2]
n3:nazevZdroje
Journal of Neural Transmission
n3:obor
n7:FH
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
7
n3:projekt
n19:NF7480
n3:rokUplatneniVysledku
n13:2010
n3:svazekPeriodika
10
n3:tvurceVysledku
Nevrlý, Martin Mareš, Jan Přikrylová Vranová, Hana Kaňovský, Petr Stejskal, David Zapletalová, Jana Hluštík, Petr
n3:wos
000284782100008
s:issn
0300-9564
s:numberOfPages
4
n15:doi
10.1007/s00702-010-0462-z
n18:organizacniJednotka
15110