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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F10%3A10215161%21RIV11-MSM-15110___
rdf:type
n6:Vysledek skos:Concept
dcterms:description
Cytotoxicity of two halogen derivatives of N6-benzyladenosine (BAPR), N6-(3-iodobenzyl)-adenosine (I-BAPR) and 2-chloro-N6-(3-iodobenzyl)-adenosine (Cl-I-BAPR), was tested in human leukemia U937 cell line. Our results revealed that their cytotoxicity was surprisingly low. I-BAPR and also Cl-I-BAPR induced cell death with morphological and biochemical hallmarks of apoptosis, although the number of apoptotic cells was significantly lower than that found for BAPR. Our data strongly suggested that the decreased cytotoxic effect of halogenated derivatives of N6-benzyladenosine was related to their reduced intracellular phosphorylation by adenosine kinase. Cytotoxicity of two halogen derivatives of N6-benzyladenosine (BAPR), N6-(3-iodobenzyl)-adenosine (I-BAPR) and 2-chloro-N6-(3-iodobenzyl)-adenosine (Cl-I-BAPR), was tested in human leukemia U937 cell line. Our results revealed that their cytotoxicity was surprisingly low. I-BAPR and also Cl-I-BAPR induced cell death with morphological and biochemical hallmarks of apoptosis, although the number of apoptotic cells was significantly lower than that found for BAPR. Our data strongly suggested that the decreased cytotoxic effect of halogenated derivatives of N6-benzyladenosine was related to their reduced intracellular phosphorylation by adenosine kinase.
dcterms:title
Halogenation of N6-benzyladenosine decreases its cytotoxicity in human leukemia cells Halogenation of N6-benzyladenosine decreases its cytotoxicity in human leukemia cells
skos:prefLabel
Halogenation of N6-benzyladenosine decreases its cytotoxicity in human leukemia cells Halogenation of N6-benzyladenosine decreases its cytotoxicity in human leukemia cells
skos:notation
RIV/61989592:15110/10:10215161!RIV11-MSM-15110___
n4:aktivita
n10:Z
n4:aktivity
Z(MSM6198959216)
n4:cisloPeriodika
8
n4:dodaniDat
n12:2011
n4:domaciTvurceVysledku
n13:9228489 n13:3774007
n4:druhVysledku
n16:J
n4:duvernostUdaju
n18:S
n4:entitaPredkladatele
n15:predkladatel
n4:idSjednocenehoVysledku
261162
n4:idVysledku
RIV/61989592:15110/10:10215161
n4:jazykVysledku
n14:eng
n4:klicovaSlova
cells; leukemia; human; cytotoxicity; decreases; N6-benzyladenosine; Halogenation
n4:klicoveSlovo
n5:Halogenation n5:human n5:N6-benzyladenosine n5:cells n5:cytotoxicity n5:leukemia n5:decreases
n4:kodStatuVydavatele
NL - Nizozemsko
n4:kontrolniKodProRIV
[85CF5F563320]
n4:nazevZdroje
Toxicology in Vitro
n4:obor
n7:CE
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
3
n4:rokUplatneniVysledku
n12:2010
n4:svazekPeriodika
24
n4:tvurceVysledku
Koudelková, Petra Doležel, Petr Mlejnek, Petr
n4:zamer
n9:MSM6198959216
s:issn
0887-2333
s:numberOfPages
5
n17:organizacniJednotka
15110