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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F10%3A10213297%21RIV11-MSM-15110___
rdf:type
skos:Concept n18:Vysledek
dcterms:description
Epithelial ovarian carcinoma (EOC) is a highly chemosensitive tumor, but most patients with advanced EOC initially responding to first-line chemotherapy with eventually relapse. Chemosensitivity testing may offer an opportunity for the optimal selection of chemotherapeutic agents for individual patients. In the present retrospective analysis we have examined the changes in chemosensitivity profiles during the course of the disease. Chemosensitivity was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5.diphenyl tetrazolium bromide (MTT) test. Two or more samples at least 14 days apart were obtained from 34 patients with ovarian cancer. Chemoresistance increased significantly at the second measurement only for paclitaxel and carbplatin, the most frequently used cytotoxic drugs. No significant difference compared to baseline was observed at subsequent measurements for any other cytotoxic agent studied, although a non-significant trend for increased chemoresistance was observed. Epithelial ovarian carcinoma (EOC) is a highly chemosensitive tumor, but most patients with advanced EOC initially responding to first-line chemotherapy with eventually relapse. Chemosensitivity testing may offer an opportunity for the optimal selection of chemotherapeutic agents for individual patients. In the present retrospective analysis we have examined the changes in chemosensitivity profiles during the course of the disease. Chemosensitivity was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5.diphenyl tetrazolium bromide (MTT) test. Two or more samples at least 14 days apart were obtained from 34 patients with ovarian cancer. Chemoresistance increased significantly at the second measurement only for paclitaxel and carbplatin, the most frequently used cytotoxic drugs. No significant difference compared to baseline was observed at subsequent measurements for any other cytotoxic agent studied, although a non-significant trend for increased chemoresistance was observed.
dcterms:title
Repeated chemosensitivity testing in patiens with epithelial ovarian carcinoma. Repeated chemosensitivity testing in patiens with epithelial ovarian carcinoma.
skos:prefLabel
Repeated chemosensitivity testing in patiens with epithelial ovarian carcinoma. Repeated chemosensitivity testing in patiens with epithelial ovarian carcinoma.
skos:notation
RIV/61989592:15110/10:10213297!RIV11-MSM-15110___
n4:aktivita
n14:Z n14:S n14:P
n4:aktivity
P(LC07017), S, Z(MSM6198959216)
n4:cisloPeriodika
3
n4:dodaniDat
n10:2011
n4:domaciTvurceVysledku
n6:3978168 n6:7146280 n6:6067204 n6:6299679 n6:7608543 n6:5290791 n6:6392377
n4:druhVysledku
n17:J
n4:duvernostUdaju
n13:S
n4:entitaPredkladatele
n7:predkladatel
n4:idSjednocenehoVysledku
284833
n4:idVysledku
RIV/61989592:15110/10:10213297
n4:jazykVysledku
n5:eng
n4:klicovaSlova
Platinum; Epithelial ovarian carcinoma: Paclitaxel; Chemosensitivity
n4:klicoveSlovo
n15:Chemosensitivity n15:Epithelial%20ovarian%20carcinoma%3A%20Paclitaxel n15:Platinum
n4:kodStatuVydavatele
IT - Italská republika
n4:kontrolniKodProRIV
[E4D188454C7A]
n4:nazevZdroje
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
n4:obor
n19:FD
n4:pocetDomacichTvurcuVysledku
7
n4:pocetTvurcuVysledku
8
n4:projekt
n12:LC07017
n4:rokUplatneniVysledku
n10:2010
n4:svazekPeriodika
31
n4:tvurceVysledku
Cwiertka, Karel Pospíšková, Markéta Špenerová, Michaela Šrámek, Vlastislav Pilka, Radovan Kudela, Milan Melichar, Bohuslav Hajdúch, Marián
n4:zamer
n8:MSM6198959216
s:issn
0392-2936
s:numberOfPages
4
n16:organizacniJednotka
15110