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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F10%3A10213257%21RIV11-MSM-15110___
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Solar light is an important factor in skin pathogenesis and the development of a number of skin disorders. UVB irradiation is known to induce oxidative stress, inflammation and DNA lesions in exposed cells. Natural compounds have been studied for their ability to modulate various lifestyle-related diseases. The use of plant compounds/extracts with screening, antioxidant and anti-inflammatory activities may also successfully protect the skin against UV-caused injury. We assessed the potency of Prunella vulgaris extract (PVE) and its main phenolic acid component, rosmarinic acid (RA), to suppress UVB-induced alterations to keratinocytes HaCaT using a solar simulator. Pre- and post-treatment of HaCaT cells with PVE (5-50 mg/l) and RA (0.18-1.8 mg/l) reduced breakage together with the apoptotic process. PVE and RA also significantly eliminated ROS production and diminished IL-6 release. Both PVE and RA prevent UVB-caused injury to keratinocytes. However their efficacy needs to be demonstrated in vivo. Solar light is an important factor in skin pathogenesis and the development of a number of skin disorders. UVB irradiation is known to induce oxidative stress, inflammation and DNA lesions in exposed cells. Natural compounds have been studied for their ability to modulate various lifestyle-related diseases. The use of plant compounds/extracts with screening, antioxidant and anti-inflammatory activities may also successfully protect the skin against UV-caused injury. We assessed the potency of Prunella vulgaris extract (PVE) and its main phenolic acid component, rosmarinic acid (RA), to suppress UVB-induced alterations to keratinocytes HaCaT using a solar simulator. Pre- and post-treatment of HaCaT cells with PVE (5-50 mg/l) and RA (0.18-1.8 mg/l) reduced breakage together with the apoptotic process. PVE and RA also significantly eliminated ROS production and diminished IL-6 release. Both PVE and RA prevent UVB-caused injury to keratinocytes. However their efficacy needs to be demonstrated in vivo.
dcterms:title
Prunella vulgaris extract and rosmarinic acid prevent UVB-induced DNA damage and oxidative stress in HaCaT keratinocytes. Prunella vulgaris extract and rosmarinic acid prevent UVB-induced DNA damage and oxidative stress in HaCaT keratinocytes.
skos:prefLabel
Prunella vulgaris extract and rosmarinic acid prevent UVB-induced DNA damage and oxidative stress in HaCaT keratinocytes. Prunella vulgaris extract and rosmarinic acid prevent UVB-induced DNA damage and oxidative stress in HaCaT keratinocytes.
skos:notation
RIV/61989592:15110/10:10213257!RIV11-MSM-15110___
n3:aktivita
n13:Z
n3:aktivity
Z(MSM6198959216)
n3:cisloPeriodika
3
n3:dodaniDat
n9:2011
n3:domaciTvurceVysledku
n4:4594266 n4:2326868 n4:2706571
n3:druhVysledku
n6:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
283269
n3:idVysledku
RIV/61989592:15110/10:10213257
n3:jazykVysledku
n8:eng
n3:klicovaSlova
DNA damage; apoptosis; oxidative stress; UVB; rosmarinic acid; Prunella vulgaris
n3:klicoveSlovo
n5:DNA%20damage n5:rosmarinic%20acid n5:apoptosis n5:UVB n5:Prunella%20vulgaris n5:oxidative%20stress
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[E6695837888B]
n3:nazevZdroje
Archives of Dermatological Research
n3:obor
n18:CE
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:rokUplatneniVysledku
n9:2010
n3:svazekPeriodika
302
n3:tvurceVysledku
Zdařilová, Adéla Vostálová, Jitka Rajnochová Svobodová, Alena
n3:zamer
n16:MSM6198959216
s:issn
0340-3696
s:numberOfPages
11
n14:organizacniJednotka
15110