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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F10%3A10212887%21RIV11-MSM-15110___
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Silymarin has anti-proliferative and anti-angiogenic activities in-xenografts of human prostate cancer (PCa). Low dietary selenium on the other hand has been associated with increased-incidence of PCa. The purpose of the current trial was to determine whether a daily administration of a silymarin and-selenium (SM-Se) combination for 6 months would alter basic clinical chemistry and oxidative stress markers, and-improve the quality of life score (QoL) in men after radical prostatectomy (RP). The selected combination of silymarin and selenium significantly reduced two markers of lipid metabolism-known to be associated with PCa progression, LDL and total cholesterol in the blood of men after RP. This-suggests that this combination may be effective in reducing PCa progression. Silymarin has anti-proliferative and anti-angiogenic activities in-xenografts of human prostate cancer (PCa). Low dietary selenium on the other hand has been associated with increased-incidence of PCa. The purpose of the current trial was to determine whether a daily administration of a silymarin and-selenium (SM-Se) combination for 6 months would alter basic clinical chemistry and oxidative stress markers, and-improve the quality of life score (QoL) in men after radical prostatectomy (RP). The selected combination of silymarin and selenium significantly reduced two markers of lipid metabolism-known to be associated with PCa progression, LDL and total cholesterol in the blood of men after RP. This-suggests that this combination may be effective in reducing PCa progression.
dcterms:title
THE SAFETY AND EFFICACY OF A SILYMARIN AND SELENIUM COMBINATION IN MEN AFTER RADICAL PROSTATECTOMY A SIX MONTH PLACEBO-CONTROLLED DOUBLE-BLIND CLINICAL TRIAL THE SAFETY AND EFFICACY OF A SILYMARIN AND SELENIUM COMBINATION IN MEN AFTER RADICAL PROSTATECTOMY A SIX MONTH PLACEBO-CONTROLLED DOUBLE-BLIND CLINICAL TRIAL
skos:prefLabel
THE SAFETY AND EFFICACY OF A SILYMARIN AND SELENIUM COMBINATION IN MEN AFTER RADICAL PROSTATECTOMY A SIX MONTH PLACEBO-CONTROLLED DOUBLE-BLIND CLINICAL TRIAL THE SAFETY AND EFFICACY OF A SILYMARIN AND SELENIUM COMBINATION IN MEN AFTER RADICAL PROSTATECTOMY A SIX MONTH PLACEBO-CONTROLLED DOUBLE-BLIND CLINICAL TRIAL
skos:notation
RIV/61989592:15110/10:10212887!RIV11-MSM-15110___
n4:aktivita
n11:Z
n4:aktivity
Z(MSM6198959216)
n4:cisloPeriodika
3
n4:dodaniDat
n12:2011
n4:domaciTvurceVysledku
n8:8738394 n8:3804763 n8:6047998 n8:2514559 n8:4594266
n4:druhVysledku
n15:J
n4:duvernostUdaju
n7:S
n4:entitaPredkladatele
n9:predkladatel
n4:idSjednocenehoVysledku
286256
n4:idVysledku
RIV/61989592:15110/10:10212887
n4:jazykVysledku
n14:eng
n4:klicovaSlova
Blood cholesterol; Plasma lipoproteins; Clinical chemistry; Radical prostatectomy; Prostate cancer; Selenium
n4:klicoveSlovo
n6:Radical%20prostatectomy n6:Selenium n6:Plasma%20lipoproteins n6:Prostate%20cancer n6:Blood%20cholesterol n6:Clinical%20chemistry
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[9EE00D481C7F]
n4:nazevZdroje
Biomedical Papers
n4:obor
n16:FJ
n4:pocetDomacichTvurcuVysledku
5
n4:pocetTvurcuVysledku
7
n4:rokUplatneniVysledku
n12:2010
n4:svazekPeriodika
2010
n4:tvurceVysledku
Vidlář, Aleš Vostálová, Jitka Ulrichová, Jitka Študent, Vladimír Vrbková, Jana Krajíček, Jiří Šimánek, Vilím
n4:zamer
n13:MSM6198959216
s:issn
1213-8118
s:numberOfPages
6
n10:organizacniJednotka
15110