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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F10%3A10212649%21RIV11-GA0-15110___
rdf:type
n18:Vysledek skos:Concept
dcterms:description
This invention relates to new disubstituted pyrazolo[4,3-d]pyrimidine derivatives and to their use in suitable utilities, especially in cancer therapy and agricultural practice. The compounds are antimitotic, anticancer, herbicidal, fungicidal and insecticidal having improved selectivity and efficiency index, i.e. that are less toxic yet more efficacious than analogues known. It is an object of this invention to provide 3-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines, which inhibit the cdks, cell proliferation, and/or induce apoptosis. A further object of the invention is to provide a method for inhibiting cell proliferation and inflammatory diseases to a mammal in need of an effective amount 3-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines.The solution of this object are 3-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines of the formula I. This invention relates to new disubstituted pyrazolo[4,3-d]pyrimidine derivatives and to their use in suitable utilities, especially in cancer therapy and agricultural practice. The compounds are antimitotic, anticancer, herbicidal, fungicidal and insecticidal having improved selectivity and efficiency index, i.e. that are less toxic yet more efficacious than analogues known. It is an object of this invention to provide 3-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines, which inhibit the cdks, cell proliferation, and/or induce apoptosis. A further object of the invention is to provide a method for inhibiting cell proliferation and inflammatory diseases to a mammal in need of an effective amount 3-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines.The solution of this object are 3-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines of the formula I.
dcterms:title
Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use
skos:prefLabel
Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use
skos:notation
RIV/61989592:15110/10:10212649!RIV11-GA0-15110___
n3:aktivita
n21:P
n3:aktivity
P(GA301/08/1649), P(GA522/09/1576)
n3:cisloPatentuVzoru
EP1475094
n3:datumUdeleniPatentuVzoru
2010-07-28+02:00
n3:dodaniDat
n14:2011
n3:domaciTvurceVysledku
n16:3774007
n3:druhVysledku
n12:P
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
283526
n3:idVysledku
RIV/61989592:15110/10:10212649
n3:jazykVysledku
n22:eng
n3:klicovaSlova
methods; preparation; process; Pyrazolo[4,3-D]pyrimidines,
n3:klicoveSlovo
n8:3-D%5Dpyrimidines n8:Pyrazolo%5B4 n8:methods n8:process n8:preparation
n3:kontrolniKodProRIV
[36C3D31EB419]
n3:licencniPoplatek
n15:A
n3:mistoVydaniPatentuVzoru
Mnichov
n3:nazevVydavatelePatentuVzoru
The European Patent Office (EPO)
n3:obor
n4:CC
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
10
n3:projekt
n6:GA522%2F09%2F1576 n6:GA301%2F08%2F1649
n3:rokUplatneniVysledku
n14:2010
n3:statVydaniPatentuVzoru
n10:DE
n3:tvurceVysledku
Strnad, Miroslav HAVLÍČEK, Libor Schmulling, Thomas Lenobel, René Moravcová, Daniela VOJTĚŠEK, Bořivoj Binarová, Pavla Uldrijan, Stjepan MLEJNEK, Petr Kryštof, Vladimír
n3:uzemniOchranaPatentu
n20:A
n3:vlastnik
n11:vlastnikVysledku
n3:vyuzitiJinymSubjektem
n7:A
n3:vyuzitiPatentuVzoru
n19:B
n3:vlastnikPatentuVzoru
Ústav experimentalni botaniky Akademie věd České republiky, Univerzita Palackého v Olomouci
n13:organizacniJednotka
15110