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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F10%3A10211952%21RIV11-MSM-15110___
rdf:type
skos:Concept n11:Vysledek
dcterms:description
Embryonic stem cells seem to have the intriguing capacity to divide indefinitely while retaining their pluripotency. This self-renewal is accomplished by specialized mechanisms of cell-cycle control. In the last few years, several studies have provided evidence for a direct link between cell-cycle regulation and cell-fate decisions in stem cells. In this review, we discuss the peculiarities of embryonic stem cell-cycle control mechanisms, implicate their involvement in cell-fate decisions, and distinguish centrosomes as important players in the self-renewal versus differentiation roulette. Embryonic stem cells seem to have the intriguing capacity to divide indefinitely while retaining their pluripotency. This self-renewal is accomplished by specialized mechanisms of cell-cycle control. In the last few years, several studies have provided evidence for a direct link between cell-cycle regulation and cell-fate decisions in stem cells. In this review, we discuss the peculiarities of embryonic stem cell-cycle control mechanisms, implicate their involvement in cell-fate decisions, and distinguish centrosomes as important players in the self-renewal versus differentiation roulette.
dcterms:title
Cell-Cycle Regulation in Embryonic Stem Cells: Centrosomal Decisions on Self-Renewal. Cell-Cycle Regulation in Embryonic Stem Cells: Centrosomal Decisions on Self-Renewal.
skos:prefLabel
Cell-Cycle Regulation in Embryonic Stem Cells: Centrosomal Decisions on Self-Renewal. Cell-Cycle Regulation in Embryonic Stem Cells: Centrosomal Decisions on Self-Renewal.
skos:notation
RIV/61989592:15110/10:10211952!RIV11-MSM-15110___
n3:aktivita
n5:Z n5:P
n3:aktivity
P(2B06077), Z(MSM6198959205)
n3:cisloPeriodika
11
n3:dodaniDat
n15:2011
n3:domaciTvurceVysledku
n4:3350819 n4:7128711 n4:2328356
n3:druhVysledku
n16:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
249832
n3:idVysledku
RIV/61989592:15110/10:10211952
n3:jazykVysledku
n9:eng
n3:klicovaSlova
centrosome; cell cycle; embryonic stem cells
n3:klicoveSlovo
n6:embryonic%20stem%20cells n6:centrosome n6:cell%20cycle
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[A4971D21EA0A]
n3:nazevZdroje
Stem Cells and Development
n3:obor
n13:EB
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
4
n3:projekt
n17:2B06077
n3:rokUplatneniVysledku
n15:2010
n3:svazekPeriodika
19
n3:tvurceVysledku
Krämer, Alwin Divoký, Vladimír Rašková Kafková, Leona Koledová, Zuzana
n3:zamer
n14:MSM6198959205
s:issn
1547-3287
s:numberOfPages
17
n8:organizacniJednotka
15110