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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F09%3A33117953%21RIV12-MSM-15110___
rdf:type
n17:Vysledek skos:Concept
dcterms:description
Toxoplasmosis is a parasitic disease associated with high mortality in immunocompromised patients. It may lead to life-threatening conditions, usually neuroinfections, pneumonia or disseminated disease. It may be potentially dangerous, especially for patients with prolonged lymphopenia or those treated with immunosuppressive drugs. In our centre, we have observed 3 cases of toxoplasmosis in patients after allogeneic haematopoietic stem cell transplantation (HSCT) (2.6 % of 116 allo-HSCT patients since 2000) and one case after autologous HSCT (0.3 % of 395 auto-HSCT patients since 1997). Toxoplasmosis is manifested by neurological symptoms including hemiparesis and paraparesis, cerebral salt-wasting syndrome (hyponatraemia and hypoosmolality), psychoorganic syndrome and signs of respiratory infection. The diagnosis was made by combining clinical signs and results of PCR and CT examinations. The patients were treated with high-dose pyrimethamine, clindamycin, co-trimoxazole and folic acid. Three of the four patients have survived with no signs of the disease. One patient died prior to treatment. The increasing use of highly immunosuppressive chemotherapy and conditioning regimens (including rituximab, fludarabine and anti-thymocyte globulin) is associated with a significant risk of toxoplasmosis. Variable manifestations, non-specific results of MRI or CT examinations and possibility of PCR negativity are the main obstacles to successful diagnosis. Toxoplasmosis is a parasitic disease associated with high mortality in immunocompromised patients. It may lead to life-threatening conditions, usually neuroinfections, pneumonia or disseminated disease. It may be potentially dangerous, especially for patients with prolonged lymphopenia or those treated with immunosuppressive drugs. In our centre, we have observed 3 cases of toxoplasmosis in patients after allogeneic haematopoietic stem cell transplantation (HSCT) (2.6 % of 116 allo-HSCT patients since 2000) and one case after autologous HSCT (0.3 % of 395 auto-HSCT patients since 1997). Toxoplasmosis is manifested by neurological symptoms including hemiparesis and paraparesis, cerebral salt-wasting syndrome (hyponatraemia and hypoosmolality), psychoorganic syndrome and signs of respiratory infection. The diagnosis was made by combining clinical signs and results of PCR and CT examinations. The patients were treated with high-dose pyrimethamine, clindamycin, co-trimoxazole and folic acid. Three of the four patients have survived with no signs of the disease. One patient died prior to treatment. The increasing use of highly immunosuppressive chemotherapy and conditioning regimens (including rituximab, fludarabine and anti-thymocyte globulin) is associated with a significant risk of toxoplasmosis. Variable manifestations, non-specific results of MRI or CT examinations and possibility of PCR negativity are the main obstacles to successful diagnosis.
dcterms:title
Toxoplasmosis after immunossuppressive therapy - our experience Toxoplasmosis after immunossuppressive therapy - our experience
skos:prefLabel
Toxoplasmosis after immunossuppressive therapy - our experience Toxoplasmosis after immunossuppressive therapy - our experience
skos:notation
RIV/61989592:15110/09:33117953!RIV12-MSM-15110___
n3:aktivita
n12:I
n3:aktivity
I
n3:cisloPeriodika
3
n3:dodaniDat
n13:2012
n3:domaciTvurceVysledku
n11:3461904 n11:8731764 n11:2556049 n11:3591263
n3:druhVysledku
n10:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
346596
n3:idVysledku
RIV/61989592:15110/09:33117953
n3:jazykVysledku
n15:eng
n3:klicovaSlova
mortality; stem cell transplantation; toxoplasmosis
n3:klicoveSlovo
n14:toxoplasmosis n14:stem%20cell%20transplantation n14:mortality
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[EAFD18EA99BD]
n3:nazevZdroje
Klinická mikrobiologie a infekční lékařství
n3:obor
n4:FD
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n13:2009
n3:svazekPeriodika
15
n3:tvurceVysledku
Raida, Luděk Bednaříková, Jana Rusiňáková, Zuzana Tomková, Jana Indrák, Karel Faber, Edgar
s:issn
1211-264X
s:numberOfPages
4
n9:organizacniJednotka
15110