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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F09%3A33116051%21RIV12-MSM-15110___
rdf:type
n15:Vysledek skos:Concept
dcterms:description
Aims and Methods: The goal was to investigate the effect of prior combined rituximab (R) and intensive chemotherapy on peripheral blood stem cell mobilization and their engraftment after stem cell transplantation (ASCT) in 69 patients with poor-risk, diffuse large B-cell lymphoma (DLBCL). Results: A statistically comparable median number of CD34+ stem cells was collected in both groups (13.80x106/ kg in the non-R group and 7.81x106/kg in the R group; p = 0.110). A trend toward greater number of CFU-GM was found in the non-R group (98.1x104/kg) compared to the R group (76.6x104/kg; p = 0.068). The non-R patients had a much higher median number of BFU-E (90.9x104/kg) than the R patients (31.3x104/kg; p = 0.001). Conclusions: Hematopoietic engraftment was rapid for both groups and no different between them. The 3-year event-free survival was 90.4 % in the R group and 67.2 % in the non-R group (p = 0.04), but there was no significant difference in the 3-year overall survival Aims and Methods: The goal was to investigate the effect of prior combined rituximab (R) and intensive chemotherapy on peripheral blood stem cell mobilization and their engraftment after stem cell transplantation (ASCT) in 69 patients with poor-risk, diffuse large B-cell lymphoma (DLBCL). Results: A statistically comparable median number of CD34+ stem cells was collected in both groups (13.80x106/ kg in the non-R group and 7.81x106/kg in the R group; p = 0.110). A trend toward greater number of CFU-GM was found in the non-R group (98.1x104/kg) compared to the R group (76.6x104/kg; p = 0.068). The non-R patients had a much higher median number of BFU-E (90.9x104/kg) than the R patients (31.3x104/kg; p = 0.001). Conclusions: Hematopoietic engraftment was rapid for both groups and no different between them. The 3-year event-free survival was 90.4 % in the R group and 67.2 % in the non-R group (p = 0.04), but there was no significant difference in the 3-year overall survival
dcterms:title
Rituximab Plus Intensive Chemotherapy Does Not Adversely Affect the Peripheral Stem Cell Mobilization and Engraftment after Hig-Dose Therapy and Autologous Stem Cell Transplantation is Patients with Diffuse Large B-Cell Lymphoma in First Complete or Partial Remission Rituximab Plus Intensive Chemotherapy Does Not Adversely Affect the Peripheral Stem Cell Mobilization and Engraftment after Hig-Dose Therapy and Autologous Stem Cell Transplantation is Patients with Diffuse Large B-Cell Lymphoma in First Complete or Partial Remission
skos:prefLabel
Rituximab Plus Intensive Chemotherapy Does Not Adversely Affect the Peripheral Stem Cell Mobilization and Engraftment after Hig-Dose Therapy and Autologous Stem Cell Transplantation is Patients with Diffuse Large B-Cell Lymphoma in First Complete or Partial Remission Rituximab Plus Intensive Chemotherapy Does Not Adversely Affect the Peripheral Stem Cell Mobilization and Engraftment after Hig-Dose Therapy and Autologous Stem Cell Transplantation is Patients with Diffuse Large B-Cell Lymphoma in First Complete or Partial Remission
skos:notation
RIV/61989592:15110/09:33116051!RIV12-MSM-15110___
n3:aktivita
n16:Z
n3:aktivity
Z(MSM6198959205)
n3:cisloPeriodika
3
n3:dodaniDat
n5:2012
n3:domaciTvurceVysledku
n9:2556049 n9:1672665 n9:1943545 n9:4327381 n9:7112084 n9:5749824 n9:3591263 n9:9959459 n9:3461904
n3:druhVysledku
n13:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
339439
n3:idVysledku
RIV/61989592:15110/09:33116051
n3:jazykVysledku
n14:eng
n3:klicovaSlova
stem cell transplantation; rituximab; diffuse large B-cell lymphoma
n3:klicoveSlovo
n4:rituximab n4:diffuse%20large%20B-cell%20lymphoma n4:stem%20cell%20transplantation
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[1A9E1EAD31BD]
n3:nazevZdroje
Biomedical Papers-Olomouc
n3:obor
n11:FD
n3:pocetDomacichTvurcuVysledku
9
n3:pocetTvurcuVysledku
12
n3:rokUplatneniVysledku
n5:2009
n3:svazekPeriodika
153
n3:tvurceVysledku
Skoumalová, Ivana Indrák, Karel Procházka, Vít Kucerová, Z. Pikalová, Zuzana Vondráková, Jana Pavlík, T. Kubová, Zuzana Dušek, L. Faber, Edgar Papajík, Tomáš Raida, Luděk
n3:zamer
n7:MSM6198959205
s:issn
1213-8118
s:numberOfPages
4
n17:organizacniJednotka
15110