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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F09%3A10224581%21RIV12-MSM-15110___
rdf:type
n14:Vysledek skos:Concept
dcterms:description
Homocysteine (HCY)is a risk factor for vascular diseases, cognitive impairment and dementia. Vascular diseases and cognitive impairment worsen the prognosis of Parkinson's disease. Risk of their occurence is advisable to minimize. The mechanism underlying elevated plasma HCY level is the O-methylation of levodopa. This reaction is catalyzed by the enzyme catechol-O-methyltransferase (COMT) and requires S-adenosylmethionine as the methyl donor for the production of S-adenosylhomocysteine, which is rapidly hydrolyzed to HCY. Elevated plasma HCY levels were found in PD patients treated with levodopa. Some animal studies shows., that addition of COMT inhibitors to levodopa should eliminate levodopa induced hyperhomocysteinemia (HHCY). Some of recent retrospective studies confirmed fact, but some of them did not. Homocysteine (HCY)is a risk factor for vascular diseases, cognitive impairment and dementia. Vascular diseases and cognitive impairment worsen the prognosis of Parkinson's disease. Risk of their occurence is advisable to minimize. The mechanism underlying elevated plasma HCY level is the O-methylation of levodopa. This reaction is catalyzed by the enzyme catechol-O-methyltransferase (COMT) and requires S-adenosylmethionine as the methyl donor for the production of S-adenosylhomocysteine, which is rapidly hydrolyzed to HCY. Elevated plasma HCY levels were found in PD patients treated with levodopa. Some animal studies shows., that addition of COMT inhibitors to levodopa should eliminate levodopa induced hyperhomocysteinemia (HHCY). Some of recent retrospective studies confirmed fact, but some of them did not.
dcterms:title
Effect of levodopa and entacapone treatment on plasma homocysteine levels in Parkinson's disease patients Effect of levodopa and entacapone treatment on plasma homocysteine levels in Parkinson's disease patients
skos:prefLabel
Effect of levodopa and entacapone treatment on plasma homocysteine levels in Parkinson's disease patients Effect of levodopa and entacapone treatment on plasma homocysteine levels in Parkinson's disease patients
skos:notation
RIV/61989592:15110/09:10224581!RIV12-MSM-15110___
n3:aktivita
n12:S
n3:aktivity
S
n3:cisloPeriodika
15
n3:dodaniDat
n10:2012
n3:domaciTvurceVysledku
n8:6251145 n8:7240961 n8:9723668 n8:6627471
n3:druhVysledku
n13:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
312151
n3:idVysledku
RIV/61989592:15110/09:10224581
n3:jazykVysledku
n9:eng
n3:klicovaSlova
L-DOPA; entacapone; Parkinson's disease; homocysteine
n3:klicoveSlovo
n4:entacapone n4:Parkinson%27s%20disease n4:L-DOPA n4:homocysteine
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[72B463EC6EA9]
n3:nazevZdroje
Parkinsonism and Related Disorders
n3:obor
n15:FH
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n10:2009
n3:svazekPeriodika
2009
n3:tvurceVysledku
Hluštík, Petr Vranová, Hana Kaňovský, Petr Langová, Kateřina Nevrlý, Martin
s:issn
1353-8020
s:numberOfPages
2
n16:organizacniJednotka
15110