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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F09%3A00009620%21RIV10-MSM-15110___
rdf:type
n15:Vysledek skos:Concept
dcterms:description
The effect of cyclosporin A (CsA) on imatinib treated Bcr-Abl positive K562 cells was studied. Similarly to other authors we found that imatinib induced apoptosis and erythroid differentiation in K562 cells. While its low concentrations induced predominantly erythroid differentiation, higher concentrations induced apoptosis. We found that CsA significantly potentiated cytotoxic effects of imatinib. A detailed analysis revealed that CsA shifted the balance between differentiation and apoptosis in favour of apoptosis. Our findings indicated that the observed effect of CsA was mediated neither through inhibition of ERK1/2 (extracellular signal-regulated kinases 1/2), nor through inhibition of p38 MAPK. We further observed that CsA might sensitise cells to apoptosis due to a changed cellular redox status as combined treatment of cells with imatinib and CsA resulted in a dramatic decrease of the ratio between reduced (GSH) and oxidised (GSSG) glutathione GSH/GSSG and in a significant suppression of thiored The effect of cyclosporin A (CsA) on imatinib treated Bcr-Abl positive K562 cells was studied. Similarly to other authors we found that imatinib induced apoptosis and erythroid differentiation in K562 cells. While its low concentrations induced predominantly erythroid differentiation, higher concentrations induced apoptosis. We found that CsA significantly potentiated cytotoxic effects of imatinib. A detailed analysis revealed that CsA shifted the balance between differentiation and apoptosis in favour of apoptosis. Our findings indicated that the observed effect of CsA was mediated neither through inhibition of ERK1/2 (extracellular signal-regulated kinases 1/2), nor through inhibition of p38 MAPK. We further observed that CsA might sensitise cells to apoptosis due to a changed cellular redox status as combined treatment of cells with imatinib and CsA resulted in a dramatic decrease of the ratio between reduced (GSH) and oxidised (GSSG) glutathione GSH/GSSG and in a significant suppression of thiored
dcterms:title
Cyclosporin A sensitises Bcr-Abl positive cells to imatinib mesylate independently of P-glykoprotein expression. Cyclosporin A sensitises Bcr-Abl positive cells to imatinib mesylate independently of P-glykoprotein expression.
skos:prefLabel
Cyclosporin A sensitises Bcr-Abl positive cells to imatinib mesylate independently of P-glykoprotein expression. Cyclosporin A sensitises Bcr-Abl positive cells to imatinib mesylate independently of P-glykoprotein expression.
skos:notation
RIV/61989592:15110/09:00009620!RIV10-MSM-15110___
n3:aktivita
n7:P n7:Z
n3:aktivity
P(NR9482), Z(MSM6198959216)
n3:cisloPeriodika
8
n3:dodaniDat
n4:2010
n3:domaciTvurceVysledku
n16:3774007 n16:1076914 n16:9228489
n3:druhVysledku
n18:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
308782
n3:idVysledku
RIV/61989592:15110/09:00009620
n3:jazykVysledku
n14:eng
n3:klicovaSlova
Differentiation; Apoptosis; K562 cells; Glutathione; Thioredoxin reductase
n3:klicoveSlovo
n6:Glutathione n6:Apoptosis n6:K562%20cells n6:Thioredoxin%20reductase n6:Differentiation
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[8FDD5C859CC9]
n3:nazevZdroje
Toxicology in Vitro
n3:obor
n12:FD
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:projekt
n8:NR9482
n3:rokUplatneniVysledku
n4:2009
n3:svazekPeriodika
23
n3:tvurceVysledku
Mlejnek, Petr Frydrych, Ivo Doležel, Petr
n3:zamer
n19:MSM6198959216
s:issn
0887-2333
s:numberOfPages
9
n11:organizacniJednotka
15110