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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F09%3A00009500%21RIV10-MSM-15110___
rdf:type
n7:Vysledek skos:Concept
dcterms:description
Myocardial ischemia/reperfusion (IR) injury leads to structural changes in the heart muscle later followed by functional decline due to progressive fibrous replacement. Hence approaches to minimize IR injury are devised, including ischemic pre-and postconditioning. Mild uncoupling of oxidative phosphorylation is one of the mechanisms suggested to be cardioprotective as chemical uncoupling mimics ischemic preconditioning. Uncoupling protein 2 is proposed to be the physiological counterpart of chemical uncouplers and is thought to be a part of the protective machinery of cardiomyocytes. Morphological changes in the mitochondrial network likely accompany the uncoupling with mitochondrial fission dampening the signals leading to cardiomyocyte death. Here we review recent data on the role of uncoupling in cardioprotection and propose that low concentrations of dietary polyphenols may elicit the same cardioprotective effect as dinitrophenol and FCCP, perhaps accounting for the famed %22French paradox Myocardial ischemia/reperfusion (IR) injury leads to structural changes in the heart muscle later followed by functional decline due to progressive fibrous replacement. Hence approaches to minimize IR injury are devised, including ischemic pre-and postconditioning. Mild uncoupling of oxidative phosphorylation is one of the mechanisms suggested to be cardioprotective as chemical uncoupling mimics ischemic preconditioning. Uncoupling protein 2 is proposed to be the physiological counterpart of chemical uncouplers and is thought to be a part of the protective machinery of cardiomyocytes. Morphological changes in the mitochondrial network likely accompany the uncoupling with mitochondrial fission dampening the signals leading to cardiomyocyte death. Here we review recent data on the role of uncoupling in cardioprotection and propose that low concentrations of dietary polyphenols may elicit the same cardioprotective effect as dinitrophenol and FCCP, perhaps accounting for the famed %22French paradox
dcterms:title
Uncouple my heart: the benefits of inefficiency Uncouple my heart: the benefits of inefficiency
skos:prefLabel
Uncouple my heart: the benefits of inefficiency Uncouple my heart: the benefits of inefficiency
skos:notation
RIV/61989592:15110/09:00009500!RIV10-MSM-15110___
n3:aktivita
n16:P n16:Z
n3:aktivity
P(GA303/08/0658), Z(MSM6198959216)
n3:cisloPeriodika
2
n3:dodaniDat
n15:2010
n3:domaciTvurceVysledku
n4:1030957 n4:3443825
n3:druhVysledku
n11:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
347565
n3:idVysledku
RIV/61989592:15110/09:00009500
n3:jazykVysledku
n13:eng
n3:klicovaSlova
Uncoupling protein 2; oxidative phosphorylation; polyphenols; ischemia pre-conditioning
n3:klicoveSlovo
n8:Uncoupling%20protein%202 n8:oxidative%20phosphorylation n8:polyphenols n8:ischemia%20pre-conditioning
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[36E770B4371E]
n3:nazevZdroje
Journal of Bioenergetics and Biomembranes
n3:obor
n10:CE
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:projekt
n12:GA303%2F08%2F0658
n3:rokUplatneniVysledku
n15:2009
n3:svazekPeriodika
41
n3:tvurceVysledku
Gabrielová, Eva Modrianský, Martin
n3:zamer
n19:MSM6198959216
s:issn
0145-479X
s:numberOfPages
4
n18:organizacniJednotka
15110