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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F09%3A00009496%21RIV10-MSM-15110___
rdf:type
skos:Concept n15:Vysledek
dcterms:description
Periodontitis is a chronic disease associated with inflammation of the tooth-supporting tissues. The inflammation is initiated by a group of gram-negative anaerobic bacteria. These express a number of irritating factors including a lipopolysaccharide (LPS), which plays a key role in periodontal disease development. Plant extracts with anti-inflammatory and anti-microbial properties have been shown to inhibit bacterial plaque formation and thus prevent chronic gingivitis. In this study we tested effects of Prunella vulgaris L. extract (PVE; 5, 10, 25 ?g/ml) and its component rosmarinic acid (RA; 1 ?g/ml) on LPS-induced oxidative damage and inflammation in human gingival fibroblasts. PVE and RA reduced reactive oxygen species (ROS) production, intracellular glutathione (GSH) depletion as well as lipid peroxidation in LPS-treated cells. Treatment with PVE and RA also inhibited LPS-induced up-regulation of interleukin 1β (IL-1β), interleukin 6 (IL-6), tumor necrosis factor-α (TNF) and suppr Periodontitis is a chronic disease associated with inflammation of the tooth-supporting tissues. The inflammation is initiated by a group of gram-negative anaerobic bacteria. These express a number of irritating factors including a lipopolysaccharide (LPS), which plays a key role in periodontal disease development. Plant extracts with anti-inflammatory and anti-microbial properties have been shown to inhibit bacterial plaque formation and thus prevent chronic gingivitis. In this study we tested effects of Prunella vulgaris L. extract (PVE; 5, 10, 25 ?g/ml) and its component rosmarinic acid (RA; 1 ?g/ml) on LPS-induced oxidative damage and inflammation in human gingival fibroblasts. PVE and RA reduced reactive oxygen species (ROS) production, intracellular glutathione (GSH) depletion as well as lipid peroxidation in LPS-treated cells. Treatment with PVE and RA also inhibited LPS-induced up-regulation of interleukin 1β (IL-1β), interleukin 6 (IL-6), tumor necrosis factor-α (TNF) and suppr
dcterms:title
PRUNELLA VULGARIS EXTRACT AND ROSMARINIC ACID SUPPRESS LIPOPOLYSACCHARIDE-INDUCED ALTERATION IN HUMAN GINGIVAL FIBROBLASTS PRUNELLA VULGARIS EXTRACT AND ROSMARINIC ACID SUPPRESS LIPOPOLYSACCHARIDE-INDUCED ALTERATION IN HUMAN GINGIVAL FIBROBLASTS
skos:prefLabel
PRUNELLA VULGARIS EXTRACT AND ROSMARINIC ACID SUPPRESS LIPOPOLYSACCHARIDE-INDUCED ALTERATION IN HUMAN GINGIVAL FIBROBLASTS PRUNELLA VULGARIS EXTRACT AND ROSMARINIC ACID SUPPRESS LIPOPOLYSACCHARIDE-INDUCED ALTERATION IN HUMAN GINGIVAL FIBROBLASTS
skos:notation
RIV/61989592:15110/09:00009496!RIV10-MSM-15110___
n3:aktivita
n8:Z
n3:aktivity
Z(MSM6198959216)
n3:cisloPeriodika
3
n3:dodaniDat
n5:2010
n3:domaciTvurceVysledku
n4:2326868 n4:2514559 n4:2706571 n4:8738394
n3:druhVysledku
n18:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
337470
n3:idVysledku
RIV/61989592:15110/09:00009496
n3:jazykVysledku
n17:eng
n3:klicovaSlova
antioxidant; anti-inflammatory activity; reactive oxygen species; cytokine
n3:klicoveSlovo
n11:anti-inflammatory%20activity n11:antioxidant n11:reactive%20oxygen%20species n11:cytokine
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[8F4BFE1867D0]
n3:nazevZdroje
Toxicology in Vitro
n3:obor
n16:CE
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n5:2009
n3:svazekPeriodika
23
n3:tvurceVysledku
Svobodová, Alena Ulrichová, Jitka Šimánek, Vilím Zdařilová, Adéla
n3:zamer
n12:MSM6198959216
s:issn
0887-2333
s:numberOfPages
7
n10:organizacniJednotka
15110