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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F08%3A10224733%21RIV12-MSM-15110___
rdf:type
skos:Concept n14:Vysledek
dcterms:description
An HPLC procedure for the determination of lamotrigine (LAM) simultaneously with other antiepileptic drugs, primidone (PD), phenobarbital (PB), phenytoin (DPH), carbamazepine (CMZ), and two active metabolites 2-phenyl-2-ethyl-malonamide (PEMA) and 10,11-dihydro-10,11-epoxycarbamazepine (EPO) was developed and validated. Within-day CV% and between-day CV% were within 10%. The developed HPLC method can be used for routine therapeutic drug monitoring both in children and adults. An HPLC procedure for the determination of lamotrigine (LAM) simultaneously with other antiepileptic drugs, primidone (PD), phenobarbital (PB), phenytoin (DPH), carbamazepine (CMZ), and two active metabolites 2-phenyl-2-ethyl-malonamide (PEMA) and 10,11-dihydro-10,11-epoxycarbamazepine (EPO) was developed and validated. Within-day CV% and between-day CV% were within 10%. The developed HPLC method can be used for routine therapeutic drug monitoring both in children and adults.
dcterms:title
Simultaneous determination of antiepileptic drugs and two active metabolites by HPLC Simultaneous determination of antiepileptic drugs and two active metabolites by HPLC
skos:prefLabel
Simultaneous determination of antiepileptic drugs and two active metabolites by HPLC Simultaneous determination of antiepileptic drugs and two active metabolites by HPLC
skos:notation
RIV/61989592:15110/08:10224733!RIV12-MSM-15110___
n3:aktivita
n18:Z n18:S n18:I
n3:aktivity
I, S, Z(MSM0021627502)
n3:cisloPeriodika
1
n3:dodaniDat
n15:2012
n3:domaciTvurceVysledku
n11:9790365
n3:druhVysledku
n4:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
394937
n3:idVysledku
RIV/61989592:15110/08:10224733
n3:jazykVysledku
n9:eng
n3:klicovaSlova
antiepileptic; HPLC
n3:klicoveSlovo
n8:antiepileptic n8:HPLC
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[5CB8F6E9A2ED]
n3:nazevZdroje
Journal of Separation Science
n3:obor
n12:FR
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n15:2008
n3:svazekPeriodika
31
n3:tvurceVysledku
Grundmann, Milan Budáková, L. Brozmanová, H. Fischer, J.
n3:zamer
n6:MSM0021627502
s:issn
1615-9306
s:numberOfPages
8
n13:organizacniJednotka
15110