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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F08%3A10224436%21RIV12-MSM-15110___
rdf:type
n16:Vysledek skos:Concept
dcterms:description
We attempted to investigate the clinicopathological correlation of renal oncocytoma (RO) with renal vein extension. We identified seven ROs with extension into the branches of renal vein. The age of seven patients ranged from 61 to 82 years. Five cases were identified; incidentally, two patients had gross hematuria. After surgery, all patients were alive and free of tumors with follow-up of 1 to 5 years (mean=3.6). Oncocytomas measured from 2.2 to 7.5 cm. Renal vein extension was grossly suspected in 5/7 cases and histologically confirmed in all seven cases. Tumor cells were positive for cytokeratins, mitochondrial antigen, epithelial membrane antigen, and parvalbumin; 5/7 tumors were focally positive for cluster of differentiation 117. Ultrastructurally, the cytoplasm was packed by mitochondria. Molecular genetic analysis did not detect abnormal numbers of chromosomes 1, 2, 6, 7, 10, 17, and XY by fluorescence in situ hybridization, loss of heterozygosity on 3p, and mutation of Von Hippel?Lindau gene in all cases. Array comparative genomic hybridization analysis of two cases did not show any major genetic changes. Conclusions are: (1) renal oncocytomas may have intravascular extension to the branches of the renal vein; (2) renal oncocytomas with intravascular extension to the branches of the renal vein have the same morphological, immunohistochemical, and cytoge- netic findings as have their counterparts without evidence of intravascular invasion; (3) the absence of metastases suggests an overall benign behavior of this tumor, but this has to be substantiated by further studies with a long-term follow-up; (4) in a renal tumor with granular cytoplasm showing renal vein extension, it is necessary to carefully exclude renal cell carcinomas (RCC) such as chromophobe RCC, oncocytic variant of papillary RCC, and granular variant of clear cell RCC. We attempted to investigate the clinicopathological correlation of renal oncocytoma (RO) with renal vein extension. We identified seven ROs with extension into the branches of renal vein. The age of seven patients ranged from 61 to 82 years. Five cases were identified; incidentally, two patients had gross hematuria. After surgery, all patients were alive and free of tumors with follow-up of 1 to 5 years (mean=3.6). Oncocytomas measured from 2.2 to 7.5 cm. Renal vein extension was grossly suspected in 5/7 cases and histologically confirmed in all seven cases. Tumor cells were positive for cytokeratins, mitochondrial antigen, epithelial membrane antigen, and parvalbumin; 5/7 tumors were focally positive for cluster of differentiation 117. Ultrastructurally, the cytoplasm was packed by mitochondria. Molecular genetic analysis did not detect abnormal numbers of chromosomes 1, 2, 6, 7, 10, 17, and XY by fluorescence in situ hybridization, loss of heterozygosity on 3p, and mutation of Von Hippel?Lindau gene in all cases. Array comparative genomic hybridization analysis of two cases did not show any major genetic changes. Conclusions are: (1) renal oncocytomas may have intravascular extension to the branches of the renal vein; (2) renal oncocytomas with intravascular extension to the branches of the renal vein have the same morphological, immunohistochemical, and cytoge- netic findings as have their counterparts without evidence of intravascular invasion; (3) the absence of metastases suggests an overall benign behavior of this tumor, but this has to be substantiated by further studies with a long-term follow-up; (4) in a renal tumor with granular cytoplasm showing renal vein extension, it is necessary to carefully exclude renal cell carcinomas (RCC) such as chromophobe RCC, oncocytic variant of papillary RCC, and granular variant of clear cell RCC.
dcterms:title
Renal oncocytoma with and without intravascular extension into the branches of renal vein have the same morphological immunohistochemical and genetic features Renal oncocytoma with and without intravascular extension into the branches of renal vein have the same morphological immunohistochemical and genetic features
skos:prefLabel
Renal oncocytoma with and without intravascular extension into the branches of renal vein have the same morphological immunohistochemical and genetic features Renal oncocytoma with and without intravascular extension into the branches of renal vein have the same morphological immunohistochemical and genetic features
skos:notation
RIV/61989592:15110/08:10224436!RIV12-MSM-15110___
n3:aktivita
n8:I n8:V
n3:aktivity
I, V
n3:cisloPeriodika
3
n3:dodaniDat
n12:2012
n3:domaciTvurceVysledku
n11:8478325
n3:druhVysledku
n9:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
392319
n3:idVysledku
RIV/61989592:15110/08:10224436
n3:jazykVysledku
n18:eng
n3:klicovaSlova
Molecular biology; Intravenous extension; Intravascular; Renal oncocytoma; Kidney
n3:klicoveSlovo
n6:Kidney n6:Intravenous%20extension n6:Molecular%20biology n6:Renal%20oncocytoma n6:Intravascular
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[5478848F7CDA]
n3:nazevZdroje
Virchows Archiv
n3:obor
n7:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
14
n3:rokUplatneniVysledku
n12:2008
n3:svazekPeriodika
452
n3:tvurceVysledku
Hora, M. Cabrero, I. Yang, X. Šíma, R. Vaněček, T. Kuroda, N. Hes, O. Martignoni, G. Perez-Montiel, D. Michal, M. Ürge, T. Dvořák, M. Brunelli, M. Jarošová, Marie
s:issn
0945-6317
s:numberOfPages
9
n13:doi
10.1007/s00428-007-0564-7
n17:organizacniJednotka
15110