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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F08%3A10224410%21RIV12-MSM-15110___
rdf:type
n10:Vysledek skos:Concept
dcterms:description
Several small case-control studies have investigated whether factor V Leiden (FVL) is a risk factor for retinal vein occlusion (RVO) and generated conflicting data. To clarify this question we performed a large two-centre case-control study and a meta-analysis of published studies. Two hundred seven consecutive patients with RVO and a control group of 150 subjects were screened between 1996 and 2006. A systematic meta-analysis was done combining our study with further 17 published European case-control studies. APC resistance was detected in 16 out of 207 (7.7%) patients and eight out of 150 (5.3%) controls. The odds ratio (OR) estimated was 1.49 with a (non-significant) 95% confidence interval (CI) of 0.62-3.57. The meta-analysis including 18 studies with a total of 1,748 patients and 2,716 controls showed a significantly higher prevalence of FVL in patients with RVO compared to healthy controls (combined OR 1.66; 95% CI 1.19-2.32). Several small case-control studies have investigated whether factor V Leiden (FVL) is a risk factor for retinal vein occlusion (RVO) and generated conflicting data. To clarify this question we performed a large two-centre case-control study and a meta-analysis of published studies. Two hundred seven consecutive patients with RVO and a control group of 150 subjects were screened between 1996 and 2006. A systematic meta-analysis was done combining our study with further 17 published European case-control studies. APC resistance was detected in 16 out of 207 (7.7%) patients and eight out of 150 (5.3%) controls. The odds ratio (OR) estimated was 1.49 with a (non-significant) 95% confidence interval (CI) of 0.62-3.57. The meta-analysis including 18 studies with a total of 1,748 patients and 2,716 controls showed a significantly higher prevalence of FVL in patients with RVO compared to healthy controls (combined OR 1.66; 95% CI 1.19-2.32).
dcterms:title
The prevalence of activated protein C (APC) resistance and factor V Leiden is significantly higher in patients with retinal vein occlusion without general risk factors The prevalence of activated protein C (APC) resistance and factor V Leiden is significantly higher in patients with retinal vein occlusion without general risk factors
skos:prefLabel
The prevalence of activated protein C (APC) resistance and factor V Leiden is significantly higher in patients with retinal vein occlusion without general risk factors The prevalence of activated protein C (APC) resistance and factor V Leiden is significantly higher in patients with retinal vein occlusion without general risk factors
skos:notation
RIV/61989592:15110/08:10224410!RIV12-MSM-15110___
n3:aktivita
n11:I
n3:aktivity
I
n3:cisloPeriodika
5
n3:dodaniDat
n5:2012
n3:domaciTvurceVysledku
n12:3943925 n12:7243529
n3:druhVysledku
n13:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
389129
n3:idVysledku
RIV/61989592:15110/08:10224410
n3:jazykVysledku
n17:eng
n3:klicovaSlova
meta-analysis; activated protein C; APC resistance; factor V Leiden; retinal vein occlusion
n3:klicoveSlovo
n8:retinal%20vein%20occlusion n8:meta-analysis n8:APC%20resistance n8:factor%20V%20Leiden n8:activated%20protein%20C
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[E2DBCF343746]
n3:nazevZdroje
Thrombosis and Haemostasis
n3:obor
n15:FD
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n5:2008
n3:svazekPeriodika
99
n3:tvurceVysledku
Slavík, Luděk Faude, S. Řehák, Jiří Siegemund, A. Krčová, Věra Müller, M. Řehák, Matuš
s:issn
0340-6245
s:numberOfPages
5
n9:organizacniJednotka
15110