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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F08%3A10213704%21RIV12-MSM-15110___
rdf:type
n16:Vysledek skos:Concept
dcterms:description
Exposure to UVA radiation is known to cause many adverse biological effects by inducing the stricken cells to produce reactive oxygen species (ROS). In recent years the use of botanicals has received considerable interest in the skin protection. Bilberry (Vaccinium myrtillus L.) fruit contains several polyphenols with strong antioxidant and anti-inflammatory properties. In this study we evaluated potential UVA preventive effect of V. myrtillus fruit extract (VME; anthocyanins, 25 % w/w) in HaCaT keratinocytes. Pre-treatment (1 h) or post-treatment (4 h) of HaCaT with VME resulted in attenuation of UVA-caused damage. Application of the extract significantly reduced UVA-stimulated ROS formation in keratinocytes. VME also prevented/reduced UVA-caused peroxidation of membrane lipids and depletion of intracellular GSH. The observed cytoprotective effect may be linked to the antioxidant activity of the plant constituents, namely anthocyanins. Exposure to UVA radiation is known to cause many adverse biological effects by inducing the stricken cells to produce reactive oxygen species (ROS). In recent years the use of botanicals has received considerable interest in the skin protection. Bilberry (Vaccinium myrtillus L.) fruit contains several polyphenols with strong antioxidant and anti-inflammatory properties. In this study we evaluated potential UVA preventive effect of V. myrtillus fruit extract (VME; anthocyanins, 25 % w/w) in HaCaT keratinocytes. Pre-treatment (1 h) or post-treatment (4 h) of HaCaT with VME resulted in attenuation of UVA-caused damage. Application of the extract significantly reduced UVA-stimulated ROS formation in keratinocytes. VME also prevented/reduced UVA-caused peroxidation of membrane lipids and depletion of intracellular GSH. The observed cytoprotective effect may be linked to the antioxidant activity of the plant constituents, namely anthocyanins.
dcterms:title
Bilberry extract reduces UVA-induced oxidative stress in HaCaT keratinocytes. A pilot study. Bilberry extract reduces UVA-induced oxidative stress in HaCaT keratinocytes. A pilot study.
skos:prefLabel
Bilberry extract reduces UVA-induced oxidative stress in HaCaT keratinocytes. A pilot study. Bilberry extract reduces UVA-induced oxidative stress in HaCaT keratinocytes. A pilot study.
skos:notation
RIV/61989592:15110/08:10213704!RIV12-MSM-15110___
n4:aktivita
n11:Z n11:P
n4:aktivity
P(FT-TA3/024), P(GP303/07/P314), Z(MSM6198959216)
n4:cisloPeriodika
4
n4:dodaniDat
n15:2012
n4:domaciTvurceVysledku
n5:4594266 n5:2326868 n5:1089935
n4:druhVysledku
n18:J
n4:duvernostUdaju
n17:S
n4:entitaPredkladatele
n19:predkladatel
n4:idSjednocenehoVysledku
357967
n4:idVysledku
RIV/61989592:15110/08:10213704
n4:jazykVysledku
n7:eng
n4:klicovaSlova
free radicals; oxidative stress; HaCaT keratinocytes; UVA radiation; Vaccinium myrtillus
n4:klicoveSlovo
n10:Vaccinium%20myrtillus n10:UVA%20radiation n10:HaCaT%20keratinocytes n10:free%20radicals n10:oxidative%20stress
n4:kodStatuVydavatele
JP - Japonsko
n4:kontrolniKodProRIV
[569294F7C6E2]
n4:nazevZdroje
BioFactors
n4:obor
n12:CE
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
4
n4:projekt
n13:GP303%2F07%2FP314 n13:FT-TA3%2F024
n4:rokUplatneniVysledku
n15:2008
n4:svazekPeriodika
33
n4:tvurceVysledku
Rambousková, Jana Svobodová, Alena Walterová, Daniela Vostálová, Jitka
n4:zamer
n9:MSM6198959216
s:issn
0951-6433
s:numberOfPages
18
n6:organizacniJednotka
15110