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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F08%3A10213685%21RIV12-MSM-15110___
rdf:type
skos:Concept n14:Vysledek
dcterms:description
Inosine triphosphate pyrophosphohydrolase (ITPase) catalyzing the pyrophosphohydrolysis of inosine triphosphate, deoxyinosine triphosphate and xanthosine triphosphate is involved in the metabolism and tolerance of thiopurine drugs. ITPase activity plays an important role in the prediction of toxicity to thiopurine therapy. Activities in dry blood spots were compared with fresh erythrocytes. Samples were incubated with inosine triphosphate, then inosine monophosphate was determined by a capillary electrophoresis method. Calculated enzyme activities obtained from dry blood spots were in good accordance with activity in fresh erythrocytes. Inosine triphosphate pyrophosphohydrolase (ITPase) catalyzing the pyrophosphohydrolysis of inosine triphosphate, deoxyinosine triphosphate and xanthosine triphosphate is involved in the metabolism and tolerance of thiopurine drugs. ITPase activity plays an important role in the prediction of toxicity to thiopurine therapy. Activities in dry blood spots were compared with fresh erythrocytes. Samples were incubated with inosine triphosphate, then inosine monophosphate was determined by a capillary electrophoresis method. Calculated enzyme activities obtained from dry blood spots were in good accordance with activity in fresh erythrocytes.
dcterms:title
ITPase activity in dry blood spots is comparable with that in fresh erythrocytes ITPase activity in dry blood spots is comparable with that in fresh erythrocytes
skos:prefLabel
ITPase activity in dry blood spots is comparable with that in fresh erythrocytes ITPase activity in dry blood spots is comparable with that in fresh erythrocytes
skos:notation
RIV/61989592:15110/08:10213685!RIV12-MSM-15110___
n3:aktivita
n18:Z
n3:aktivity
Z(MSM6198959205)
n3:cisloPeriodika
6
n3:dodaniDat
n5:2012
n3:domaciTvurceVysledku
n11:6401309 n11:2714035
n3:druhVysledku
n13:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
373451
n3:idVysledku
RIV/61989592:15110/08:10213685
n3:jazykVysledku
n7:eng
n3:klicovaSlova
dry blood spots; capillary electrophoresis; ITPase; enzyme activity
n3:klicoveSlovo
n10:capillary%20electrophoresis n10:enzyme%20activity n10:dry%20blood%20spots n10:ITPase
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[0D5CD68F2EFD]
n3:nazevZdroje
Nucleosides Nucleotides and Nucleic Acids
n3:obor
n6:CB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n5:2008
n3:svazekPeriodika
27
n3:tvurceVysledku
Friedecký, David Vyskočilová, Petra Adam, Tomáš Tomková, Jana
n3:zamer
n16:MSM6198959205
s:issn
1525-7770
s:numberOfPages
5
n17:organizacniJednotka
15110