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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F08%3A00009701%21RIV10-MSM-15110___
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Aims: To report a case of successful pregnancy in a patient with chronic myelogenous leukemia treated with imatinib mesylate for the fi rst 4 months of pregnancy. Results: Imatinib mesylate is potentially teratogenic and its use during pregnancy in humans can lead to abortion or development of fetal abnormalities in nearly 40% of fully reported cases. We report a case of a 28-year-old woman who delivered a healthy child of normal weight after having been treated with imatinib for Ph1-positive CML during the fi rst four months of her pregnancy. She refused advocated interruption and for the rest of the pregnancy was treated with interferon. The treatment was associated with a rapid 2-log increase in the leukemia clone measured by the real-time polymerase chain reaction. Reintroduction of imatinib after delivery resulted in achievement of the complete cytogenetic response again. Conclusions: We discuss possible strategies for successful management of pregnancy in CML patients treated with imat Aims: To report a case of successful pregnancy in a patient with chronic myelogenous leukemia treated with imatinib mesylate for the fi rst 4 months of pregnancy. Results: Imatinib mesylate is potentially teratogenic and its use during pregnancy in humans can lead to abortion or development of fetal abnormalities in nearly 40% of fully reported cases. We report a case of a 28-year-old woman who delivered a healthy child of normal weight after having been treated with imatinib for Ph1-positive CML during the fi rst four months of her pregnancy. She refused advocated interruption and for the rest of the pregnancy was treated with interferon. The treatment was associated with a rapid 2-log increase in the leukemia clone measured by the real-time polymerase chain reaction. Reintroduction of imatinib after delivery resulted in achievement of the complete cytogenetic response again. Conclusions: We discuss possible strategies for successful management of pregnancy in CML patients treated with imat
dcterms:title
SUCCESSFUL CHILDBIRTH IN A PATIENT WITH CHRONIC MYELOGENOUS LEUKEMIA TREATED WITH IMATINIB MESYLATE DURING EARLY PREGNANCY SUCCESSFUL CHILDBIRTH IN A PATIENT WITH CHRONIC MYELOGENOUS LEUKEMIA TREATED WITH IMATINIB MESYLATE DURING EARLY PREGNANCY
skos:prefLabel
SUCCESSFUL CHILDBIRTH IN A PATIENT WITH CHRONIC MYELOGENOUS LEUKEMIA TREATED WITH IMATINIB MESYLATE DURING EARLY PREGNANCY SUCCESSFUL CHILDBIRTH IN A PATIENT WITH CHRONIC MYELOGENOUS LEUKEMIA TREATED WITH IMATINIB MESYLATE DURING EARLY PREGNANCY
skos:notation
RIV/61989592:15110/08:00009701!RIV10-MSM-15110___
n4:aktivita
n10:S n10:Z
n4:aktivity
S, Z(MSM6198959205)
n4:cisloPeriodika
152
n4:dodaniDat
n11:2010
n4:domaciTvurceVysledku
n6:5879590 n6:2556049 n6:9589864 n6:8478325 n6:3224716 n6:9959459 n6:3461904 n6:8227659 n6:4327381
n4:druhVysledku
n5:J
n4:duvernostUdaju
n18:S
n4:entitaPredkladatele
n7:predkladatel
n4:idSjednocenehoVysledku
398297
n4:idVysledku
RIV/61989592:15110/08:00009701
n4:jazykVysledku
n13:eng
n4:klicovaSlova
Chronic myelogenous leukemia; Pregnancy; Imatinib mesylate; Interferon alpha
n4:klicoveSlovo
n14:Pregnancy n14:Interferon%20alpha n14:Imatinib%20mesylate n14:Chronic%20myelogenous%20leukemia
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[2D19F47EC55C]
n4:nazevZdroje
Biomedical Papers
n4:obor
n9:FD
n4:pocetDomacichTvurcuVysledku
9
n4:pocetTvurcuVysledku
9
n4:rokUplatneniVysledku
n11:2008
n4:svazekPeriodika
2008
n4:tvurceVysledku
Skoumalová, Ivana Procházka, Martin Rožmanová, Šárka Šantavá, Alena Indrák, Karel Jarošová, Marie Vondráková, Jana Faber, Edgar Rohoň, Peter
n4:zamer
n16:MSM6198959205
s:issn
1213-8118
s:numberOfPages
3
n15:organizacniJednotka
15110