This HTML5 document contains 46 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n13http://localhost/temp/predkladatel/
n18http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n8http://linked.opendata.cz/ontology/domain/vavai/
n4http://linked.opendata.cz/resource/domain/vavai/zamer/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n12http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F61989592%3A15110%2F08%3A00007375%21RIV09-MSM-15110___/
n6http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n15http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n17http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n7http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n14http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n9http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n5http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F08%3A00007375%21RIV09-MSM-15110___
rdf:type
n8:Vysledek skos:Concept
dcterms:description
Cell death-inducing DFF[DNA fragmentation factor]-like effector-a (CIDEa), may initiate apoptosis by disrupting a complex consisting of 40-kDa caspase-3-activated nuclease (DFF40/CAD) and its 45-kDa inhibitor (DFF45/ICAD). CIDEa, however, was found to be localized in mitochondria. We have performed immunodetection of CIDEa in whole cells and subcellular fractions of HeLa cells adapted for a tetracycline-inducible CIDEa expression. Using immunocytochemistry we observed redistribution, enhanced upon treatment with camptothecin or valinomycin, of CIDEa to nucleus. Similarly, CIDEa content increased in the nuclear fraction but decreased in cytosolic fraction in cells treated to initiate apoptosis. We hypothesize that CIDEa is sequestered in mitochondria while transfer of this potentially dangerous protein from mitochondria into nucleus intensifies or even initiates apoptosis. Cell death-inducing DFF[DNA fragmentation factor]-like effector-a (CIDEa), may initiate apoptosis by disrupting a complex consisting of 40-kDa caspase-3-activated nuclease (DFF40/CAD) and its 45-kDa inhibitor (DFF45/ICAD). CIDEa, however, was found to be localized in mitochondria. We have performed immunodetection of CIDEa in whole cells and subcellular fractions of HeLa cells adapted for a tetracycline-inducible CIDEa expression. Using immunocytochemistry we observed redistribution, enhanced upon treatment with camptothecin or valinomycin, of CIDEa to nucleus. Similarly, CIDEa content increased in the nuclear fraction but decreased in cytosolic fraction in cells treated to initiate apoptosis. We hypothesize that CIDEa is sequestered in mitochondria while transfer of this potentially dangerous protein from mitochondria into nucleus intensifies or even initiates apoptosis. Abstrakt. DFFa podobný faktor indukující buněčnou smrt, CIDEa, může iniciovat apoptózu rozložením komplexu sestávajícího z nukleázy aktivující kaspázu-3 o velikosti 40-kDa (DFF40/CAD) a jeho inhibitoru o velikosti 45-kDa (DFF45/ICAD). Nicméně bylo zjištěno, že se CIDEa nachází v mitochodnriích. Provedli jsme imunodetekci CIDEa v celých buňkách a subcelulárních frakcích HeLa buněk adaptovaných na tetracyklinem indukovanou expresi CIDEa. S využitím imunocytochemie jsem pozorovali redistribuci CIDEa do jádra, zvýšenou působením camptothecinu nebo valinomycinu. Podobně byl obsah CIDEa zvýšený v nukleární frakci a naopak snížený v cytosolické frakci v buňkách vedoucí k iniciaci apoptózy. Hypotéza zní, že CIDEa je osamocená v mitochondriích, přičemž přenos tohoto potenciálně nebezpečného proteinu z mitochondrií do jádra zvyšuje nebo dokonce iniciuje apoptózu.
dcterms:title
Redistribution of cell death-inducing DNA fragmentation factor-like effector-a (CIDEa) from mitochondria to nucleus is associated with apoptosis in HeLa cells Redistribution of cell death-inducing DNA fragmentation factor-like effector-a (CIDEa) from mitochondria to nucleus is associated with apoptosis in HeLa cells Redistribuce CIDEa (DFFa podobný faktor indukující buněčnou smrt) z mitochondrií do jádra v HeLa buňkách
skos:prefLabel
Redistribution of cell death-inducing DNA fragmentation factor-like effector-a (CIDEa) from mitochondria to nucleus is associated with apoptosis in HeLa cells Redistribution of cell death-inducing DNA fragmentation factor-like effector-a (CIDEa) from mitochondria to nucleus is associated with apoptosis in HeLa cells Redistribuce CIDEa (DFFa podobný faktor indukující buněčnou smrt) z mitochondrií do jádra v HeLa buňkách
skos:notation
RIV/61989592:15110/08:00007375!RIV09-MSM-15110___
n3:aktivita
n17:Z
n3:aktivity
Z(MSM6198959216)
n3:cisloPeriodika
2
n3:dodaniDat
n5:2009
n3:domaciTvurceVysledku
n18:1030957
n3:druhVysledku
n14:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
391832
n3:idVysledku
RIV/61989592:15110/08:00007375
n3:jazykVysledku
n7:eng
n3:klicovaSlova
CIDEa; Mitochondria; Apoptosis; Migration to nucleus; HeLa cells
n3:klicoveSlovo
n6:HeLa%20cells n6:Migration%20to%20nucleus n6:CIDEa n6:Apoptosis n6:Mitochondria
n3:kodStatuVydavatele
SK - Slovenská republika
n3:kontrolniKodProRIV
[CF1B9D40895A]
n3:nazevZdroje
General Physiology and Biophysics
n3:obor
n9:CE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n5:2008
n3:svazekPeriodika
27
n3:tvurceVysledku
Ježek, Petr Šantorová, Jitka Valoušková, Eva Modrianský, Martin Smolková, Katarina
n3:zamer
n4:MSM6198959216
s:issn
0231-5882
s:numberOfPages
4
n13:organizacniJednotka
15110