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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F08%3A00006994%21RIV09-MSM-15110___
rdf:type
skos:Concept n15:Vysledek
dcterms:description
Background: Discovery of uncoupling protein 2 (UCP2) in 1997 and demonstration of its wide tissue expression has triggered an important question about controlled oxidative phosphorylation uncoupling and the physiological function of this process. Uncoupling protein 2 (UcP2) is a mitochondrial protein that can infl uence the mitochondrial membrane potential and hence the production of reactive oxygen species by mitochondria. It is also thought to be involved in apoptotic signaling pathways and it has been suggested to be important in cardio- and neuroprotection. Methods and results: We examined the recent literature (2003?2007) in the MedLine database for evidence linking p38, one of the stress-related protein kinases, with modulation of UCP2 expression in the heart. While two reports clearly demonstrate p38 as down-regulating UcP2 expression, only circumstantial evidence exists for cardiomyocytes. Confl icting results on p38-regulated cardiomyocyte survival after ischemia leave an open venue f Profil: Objev uncoupling proteinu 2 (UCP2) v roce 1997 a demonstrace jeho exprese v mnoha tkáních vzbudila důležitou otázku o kontrolovaném odpřažení oxidativní fosforylace a fyziologické funkci tohoto procesu. Uncoupling protein (UCP2) je mitochondriální protein, který může ovlivnit mitochondriální membránový potenciál a vyvolat produkci reaktivních kyslíkových radikálů mitochondriemi. Zdá se, že UCP2 je zapojen do apoptotické signální dráhy a je důležitý v kardio- a neuroprotekci. Metody a výsledky: Pro důkaz spojení p38, jedné z proteinkináz související se stresem, s modulací exprese UCP2 v srdci jsme prověřili současnou literaturu (2003-2007) v databázi MedLine. Zatímco dvě studie jasně ukazují p38 jako regulátor snižující expresi UCP2, pro kardiomyocyty existují pouze nepřímé důkazy. Protikladné závěry o přežití kardiomyocytů po ischemii regulované p38 vedou k otevřenému místu pro hypotézu o odlišné regulaci exprese proteinu, zahrnující UCP2. Shrnutí: Ke zhodnocení důkazů spojení UCP2 a jeh Background: Discovery of uncoupling protein 2 (UCP2) in 1997 and demonstration of its wide tissue expression has triggered an important question about controlled oxidative phosphorylation uncoupling and the physiological function of this process. Uncoupling protein 2 (UcP2) is a mitochondrial protein that can infl uence the mitochondrial membrane potential and hence the production of reactive oxygen species by mitochondria. It is also thought to be involved in apoptotic signaling pathways and it has been suggested to be important in cardio- and neuroprotection. Methods and results: We examined the recent literature (2003?2007) in the MedLine database for evidence linking p38, one of the stress-related protein kinases, with modulation of UCP2 expression in the heart. While two reports clearly demonstrate p38 as down-regulating UcP2 expression, only circumstantial evidence exists for cardiomyocytes. Confl icting results on p38-regulated cardiomyocyte survival after ischemia leave an open venue f
dcterms:title
Modulation of UCP2 expression by p38 - a link to cardioprotection Modulation of UCP2 expression by p38 - a link to cardioprotection Modulace exprese UCP2 p38 - souvislost s kardioprotekcí
skos:prefLabel
Modulace exprese UCP2 p38 - souvislost s kardioprotekcí Modulation of UCP2 expression by p38 - a link to cardioprotection Modulation of UCP2 expression by p38 - a link to cardioprotection
skos:notation
RIV/61989592:15110/08:00006994!RIV09-MSM-15110___
n3:aktivita
n11:P n11:Z
n3:aktivity
P(GA303/08/0658), Z(MSM6198959216)
n3:cisloPeriodika
1
n3:dodaniDat
n9:2009
n3:domaciTvurceVysledku
n17:1030957
n3:druhVysledku
n7:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
380284
n3:idVysledku
RIV/61989592:15110/08:00006994
n3:jazykVysledku
n12:eng
n3:klicovaSlova
Mitochondria; Oxidative phosphorylation; Uncoupling; Mitogen-activated protein kinase; Reactive oxygen species
n3:klicoveSlovo
n4:Reactive%20oxygen%20species n4:Mitochondria n4:Uncoupling n4:Oxidative%20phosphorylation n4:Mitogen-activated%20protein%20kinase
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[96FC60414613]
n3:nazevZdroje
Biomedical Papers
n3:obor
n13:CE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
2
n3:projekt
n8:GA303%2F08%2F0658
n3:rokUplatneniVysledku
n9:2008
n3:svazekPeriodika
152
n3:tvurceVysledku
Valoušková, Eva Modrianský, Martin
n3:zamer
n14:MSM6198959216
s:issn
1213-8118
s:numberOfPages
5
n19:organizacniJednotka
15110