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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F08%3A00006194%21RIV09-MZ0-15110___
rdf:type
skos:Concept n14:Vysledek
dcterms:description
Tato studie zkoumá asociaci mezi pracovní expozicí pesticidům a riziku vzniku karcinomu z ledvinných buněk (RCC). V návaznosti na předchozí publikaci Buzio a kol. jsme se zabývali studiem, zda by tato asociace mohla být modifikována genotypy M1 a T1 glutathion S transferázy (GSTM1 a GSTT1).Data o celoživotní profesionální expozici byla získána pomocí interview od 1,097 RCC případů a 1,476 kontrol ze střední a východní Evropy. Byly hodnoceny profesionální expozice, která trvaly nejméně 12 měsíců, ty byly kódovány podle expozice pesticidu a hodnoceny podle frekvence a intenzity expozice. GSTM1 a T1 genové delece byly analyzovány za použití TaqMan(R) testů. Signifikantní nárůst rizika RCC byl pozorován u subjektů exponovaných pesticidům (OR: 1.60; 95% IS: 1.00-2.55). Po stratifikaci podle genotypů bylo pozorováno zvýšené riziko u subjektů s nejméně jednou GSTM1 aktivní alelou (OR: 4.00; 95% IS: 1.55-10.33) ale ne u subjektů se dvěma inaktivními alelami GSTM1, v porovnání s neexponovanými subjekty se dvě This study investigated associations between occupational pesticide exposure and renal cell carcinoma (RCC) risk. To follow-up on a previous report by Buzio et al., we also considered whether this association could be modified by glutathione S-transferase M1 and T1 (GSTM1 and GSTT1) genotypes. About 1097 RCC cases and 1476 controls from Central and Eastern Europe were interviewed to collect data on lifetime occupational histories. Occupational information for jobs held for at least 12 months duration was coded for pesticide exposures and assessed for frequency and intensity of exposure. GSTM1 and GSTT1 gene deletions were analyzed using TaqMan assays. A significant increase in RCC risk was observed among subjects ever exposed to pesticides [odds ratio (OR): 1.60; 95% confidence interval (CI): 1.00-2.55]. After stratification by genotypes, increased risk was observed among exposed subjects with at least one GSTM1 active allele (OR: 4.00; 95% CI: 1.55-10.33) but not among exposed subjects with two GSTM1 This study investigated associations between occupational pesticide exposure and renal cell carcinoma (RCC) risk. To follow-up on a previous report by Buzio et al., we also considered whether this association could be modified by glutathione S-transferase M1 and T1 (GSTM1 and GSTT1) genotypes. About 1097 RCC cases and 1476 controls from Central and Eastern Europe were interviewed to collect data on lifetime occupational histories. Occupational information for jobs held for at least 12 months duration was coded for pesticide exposures and assessed for frequency and intensity of exposure. GSTM1 and GSTT1 gene deletions were analyzed using TaqMan assays. A significant increase in RCC risk was observed among subjects ever exposed to pesticides [odds ratio (OR): 1.60; 95% confidence interval (CI): 1.00-2.55]. After stratification by genotypes, increased risk was observed among exposed subjects with at least one GSTM1 active allele (OR: 4.00; 95% CI: 1.55-10.33) but not among exposed subjects with two GSTM1
dcterms:title
Renal cell carcinoma, occupational pesticide exposure and modification by glutathione S-transferase polymorphisms Renal cell carcinoma, occupational pesticide exposure and modification by glutathione S-transferase polymorphisms Karcinom z ledvinných buněk, pracovní expozice pesticidům a modifikace polymorfismu glutathion S-transferázy
skos:prefLabel
Karcinom z ledvinných buněk, pracovní expozice pesticidům a modifikace polymorfismu glutathion S-transferázy Renal cell carcinoma, occupational pesticide exposure and modification by glutathione S-transferase polymorphisms Renal cell carcinoma, occupational pesticide exposure and modification by glutathione S-transferase polymorphisms
skos:notation
RIV/61989592:15110/08:00006194!RIV09-MZ0-15110___
n3:aktivita
n15:O n15:P
n3:aktivity
O, P(NR9029)
n3:cisloPeriodika
8
n3:dodaniDat
n7:2009
n3:domaciTvurceVysledku
n8:3661067 n8:2512343
n3:druhVysledku
n16:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
392316
n3:idVysledku
RIV/61989592:15110/08:00006194
n3:jazykVysledku
n17:eng
n3:klicovaSlova
CI, confidence interval; GST, glutathione S-transferase; OR, odds ratio; RCC, renal cell carcinoma
n3:klicoveSlovo
n5:confidence%20interval n5:GST n5:CI n5:RCC n5:glutathione%20S-transferase n5:renal%20cell%20carcinoma n5:OR n5:odds%20ratio
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[272DC2E8E806]
n3:nazevZdroje
Carcinogenesis
n3:obor
n11:EB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
10
n3:projekt
n9:NR9029
n3:rokUplatneniVysledku
n7:2008
n3:svazekPeriodika
29
n3:tvurceVysledku
Zaridze, David Boffeta, Paolo Kollárová, Helena Karami, Sara Mates, Dana Janout, Vladimír Navrátilová, Marie Hung J, Rayjean Stewart, T. Rothman, Nathaniel
s:issn
0143-3334
s:numberOfPages
5
n13:organizacniJednotka
15110