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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F08%3A00006169%21RIV09-MZ0-15110___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
PURPOSE: Bmi-1 is a Polycomb group member which participates in many physiological processes as well as in a wide spectrum of cancers. The aim of this study was to investigate Bmi-1 expression in non-small cell lung cancer (NSCLC) in respect to clinicopathological features and therapeutic outcomes. METHODS: Immunohistochemical staining for Bmi-1 was performed on tissue microarrays (TMAs) constructed from 179 formalin-fixed and paraffin-embedded NSCLC samples (106 squamous, 58 adeno-, and 15 large cell carcinomas). Data were subject to statistical analysis by SPSS. RESULTS: Overall evaluation of all tumor cases showed that 20 (11.43%) were negative, 37 (21.14%) showed weak, 65 (37.14%) moderate and 57 (32.57%) strong nuclear positivity for Bmi-1. Statistical analysis of our data revealed that the expression of Bmi-1 was significantly higher in stage III (P = 10(-6)) and stage IV (P = 10(-5)) tumors compared to stages I and II tumors. The administration of adjuvant chemotherapy significantly increased D PURPOSE: Bmi-1 is a Polycomb group member which participates in many physiological processes as well as in a wide spectrum of cancers. The aim of this study was to investigate Bmi-1 expression in non-small cell lung cancer (NSCLC) in respect to clinicopathological features and therapeutic outcomes. METHODS: Immunohistochemical staining for Bmi-1 was performed on tissue microarrays (TMAs) constructed from 179 formalin-fixed and paraffin-embedded NSCLC samples (106 squamous, 58 adeno-, and 15 large cell carcinomas). Data were subject to statistical analysis by SPSS. RESULTS: Overall evaluation of all tumor cases showed that 20 (11.43%) were negative, 37 (21.14%) showed weak, 65 (37.14%) moderate and 57 (32.57%) strong nuclear positivity for Bmi-1. Statistical analysis of our data revealed that the expression of Bmi-1 was significantly higher in stage III (P = 10(-6)) and stage IV (P = 10(-5)) tumors compared to stages I and II tumors. The administration of adjuvant chemotherapy significantly increased D Cíl: Bmi-1 je člen polykomb. skupiny, ktrá se účastní mnoha fyziologických procesů, stejně jako v širokém spektru druhů rakoviny. Cílem této studie bylo prozkoumat Bmi-1 expresi u nemalobuněčné rakoviny plic (NSCLC) s ohledme na klinickopatologické znaky a terapeutické závěry.
dcterms:title
Prognostic value of Bmi-1 oncoprotein expression in NSCLC patients: a tissue microarray study. Prognostická hodnota Bmi-1 onkoproteinové exprese u NSCLC pacientů: a tissue microarray study. Prognostic value of Bmi-1 oncoprotein expression in NSCLC patients: a tissue microarray study.
skos:prefLabel
Prognostická hodnota Bmi-1 onkoproteinové exprese u NSCLC pacientů: a tissue microarray study. Prognostic value of Bmi-1 oncoprotein expression in NSCLC patients: a tissue microarray study. Prognostic value of Bmi-1 oncoprotein expression in NSCLC patients: a tissue microarray study.
skos:notation
RIV/61989592:15110/08:00006169!RIV09-MZ0-15110___
n4:aktivita
n7:S n7:P n7:Z
n4:aktivity
P(NR8370), P(NR8425), S, Z(MSM6198959216)
n4:cisloPeriodika
1
n4:dodaniDat
n10:2009
n4:domaciTvurceVysledku
n5:7444540 n5:9420975 n5:5281415 n5:7608543 n5:2998556 n5:6521681 n5:9582320 n5:8692386 n5:6824137
n4:druhVysledku
n9:J
n4:duvernostUdaju
n12:S
n4:entitaPredkladatele
n13:predkladatel
n4:idSjednocenehoVysledku
390192
n4:idVysledku
RIV/61989592:15110/08:00006169
n4:jazykVysledku
n18:eng
n4:klicovaSlova
Prognostic value of Bmi-1 oncoprotein expression
n4:klicoveSlovo
n15:Prognostic%20value%20of%20Bmi-1%20oncoprotein%20expression
n4:kodStatuVydavatele
DE - Spolková republika Německo
n4:kontrolniKodProRIV
[3EF3BCA5A4A4]
n4:nazevZdroje
Journal of cancer research and clinical oncology
n4:obor
n19:FD
n4:pocetDomacichTvurcuVysledku
9
n4:pocetTvurcuVysledku
12
n4:projekt
n14:NR8370 n14:NR8425
n4:rokUplatneniVysledku
n10:2008
n4:svazekPeriodika
1
n4:tvurceVysledku
Radová, Lenka Fridman, E. Ehrmann, Jiří Kolář, Zdeněk Klein, Jiří Murray, P. G. Kopolovic, J. Kolek, Vitězslav Knížetová, Petra Vrzalíková, Kateřina Škarda, Jozef Hajdúch, Marián
n4:zamer
n17:MSM6198959216
s:issn
0171-5216
s:numberOfPages
15
n6:organizacniJednotka
15110