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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F07%3A00004398%21RIV08-MSM-15110___
rdf:type
n12:Vysledek skos:Concept
dcterms:description
Sanguinarin, kvartérní benzofenantridinový alkaloid, vykazuje antimikrobiální a protizánětlivou aktivitu a z tohoto důvodu je používán v přípravcích ústní hygieny a potravních doplňcích. Jeho metabolismus a osud v organismu je předmětem nepřetržitých vědeckých debat. V tomto článku sumarizujeme současné znalosti o metabolismu sanguinarinu. Ukazujeme zejména, že: (i) Sanguinarin není transformován na 3,4-benzakridin a že literatura popisující tuto sloučeninu jako metabolit sanguinarinu je založena na artefaktech a misinterpretacích, které se v průběhem času staly dogmatem; (ii) Sanguinarin je přeměňován na dihydrosanguinarin in vivo, a že tato konverze je pravděpodobně detoxikační dráhou; (iii) Biologická aktivity sanguinarinu je ovlivněna signální dráhou aryl uhlovodíkového receptoru. Sanguinarine, a quaternary benzo[c]phenanthridine alkaloid, exhibits antimicrobial and anti-inflammatory activities and for this reason it is used in dental hygiene products and feed additives. Its metabolism and disposition is the subject of constant scientific discourse. In this paper we summarize current knowledge on sanguinarine metabolism. We show in particular that: (i) Sanguinarine is not transformed to 3,4-benzacridine and that the literature reporting this compound as a metabolite of sanguinarine is based on artifacts and misinterpretations that in course of time have created a dogma; (ii) Sanguinarine is converted to dihydrosanguinarine in vivo, the conversion being tentatively a detoxication pathway; (iii) Aryl hydrocarbon receptor metabolic signaling pathways modulate sanguinarine biological activity. Sanguinarine, a quaternary benzo[c]phenanthridine alkaloid, exhibits antimicrobial and anti-inflammatory activities and for this reason it is used in dental hygiene products and feed additives. Its metabolism and disposition is the subject of constant scientific discourse. In this paper we summarize current knowledge on sanguinarine metabolism. We show in particular that: (i) Sanguinarine is not transformed to 3,4-benzacridine and that the literature reporting this compound as a metabolite of sanguinarine is based on artifacts and misinterpretations that in course of time have created a dogma; (ii) Sanguinarine is converted to dihydrosanguinarine in vivo, the conversion being tentatively a detoxication pathway; (iii) Aryl hydrocarbon receptor metabolic signaling pathways modulate sanguinarine biological activity.
dcterms:title
Metabolismus sanguinarinu: Fakta a mýty Metabolism of sanguinarine: the facts and the myths Metabolism of sanguinarine: the facts and the myths
skos:prefLabel
Metabolism of sanguinarine: the facts and the myths Metabolism of sanguinarine: the facts and the myths Metabolismus sanguinarinu: Fakta a mýty
skos:notation
RIV/61989592:15110/07:00004398!RIV08-MSM-15110___
n3:strany
173-175
n3:aktivita
n4:Z
n3:aktivity
Z(MSM6198959216)
n3:cisloPeriodika
2
n3:dodaniDat
n16:2008
n3:domaciTvurceVysledku
n6:8069239 n6:8738394
n3:druhVysledku
n13:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
433005
n3:idVysledku
RIV/61989592:15110/07:00004398
n3:jazykVysledku
n14:eng
n3:klicovaSlova
Sanguinarine; Biotransformation; Metabolites; Cytochrome P450; Aryl hydrogen receptor
n3:klicoveSlovo
n10:Sanguinarine n10:Biotransformation n10:Aryl%20hydrogen%20receptor n10:Cytochrome%20P450 n10:Metabolites
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[9195F12B028F]
n3:nazevZdroje
Current Drug Metabolism
n3:obor
n8:CE
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:rokUplatneniVysledku
n16:2007
n3:svazekPeriodika
8
n3:tvurceVysledku
Dvořák, Zdeněk Šimánek, Vilím
n3:zamer
n15:MSM6198959216
s:issn
1389-2002
s:numberOfPages
3
n17:organizacniJednotka
15110