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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F07%3A00004356%21RIV08-MSM-15110___
rdf:type
n15:Vysledek skos:Concept
dcterms:description
Introduction: Sentinellymph node (SLN) biopsy and subsequent clinical assessment show different results in some patients with malignant melanoma (MM). The incidence of a false negative SLN is less than 2% in a case of comparison of SLN status with a histological finding in the remaining lymph nodes in the Iymphatic basin. However, the incidence of lymphatic metastases in the adjacent lymphatic basins varies in patients with negative SLN from4% to 27% duringthe follow-up (Mariani G et a1.JNucl Med 2002; 43: 811-827). The aim of the study was to evaluate this parameter in a large group ofpatients. Methods: 170 consecutive patients with MM underwent SLN biopsy and subsequently were followed at the Dept. of Oncology. 2 patients were excluded from the study due to the local recurrence with secondary lymph node metastasis, therefore a total of 168 patients were studied. Loca1ization of MMs: 91 trunk, 67 extremities, 10 head and neck. TNM classification: 48 pTI, 65 pT2, 32 pT3, 19 pT4, 4 pTiS. T Cílem studie bylo pomocí klinického sledování zhodnotit spolehlivost biopsie sentinelových lymfatických uzlin (SLU) při detekci uzlinových metastáz u pacientů (pac.) s maligním melanomem (MM). Celkem byla SLU biopsie provedena u 170 pac. s MM. 2 pacienti s lokální recidivou MM byli vyloučeni ze studie pro možnost vzniku uzlinové metastázy na základě recidivy. Celkem hodnoceno 168 osob. Lokalizace MM: 91 trup, 67 končetiny, 10 hlava a krk. TNM: 48 pT1, 65 pT2, 32 pT3, 19 pT4, 4 pTiS. Střední doba sledování 2,6 roku (0,5-5,7, medián 2,4 roku). SLU nalezeny u všech pac. ? 100% úspěšnost detekce SLU. Metastázy v SLU detekovány u 25/168 pac. (1/48 pT1, 6/65 pT2, 8/32 pT3, 10/19 pT4). Následné klinické sledování zjistilo lymfatické metastázy u dalších 4 pac.(1 pT2, 1pT3, 2 pT4), z toho ve 3 případech šlo o MM na distálních partiích dolních končetin. Senzitivita SLU biopsie 86 %, negativní prediktivní hodnota 97 %. Při hodnocení bez 6 pacientů s MM na noze: senzitivita 96,1%, NPV 99,3%. U 3 pac. zjištěny vz Introduction: Sentinellymph node (SLN) biopsy and subsequent clinical assessment show different results in some patients with malignant melanoma (MM). The incidence of a false negative SLN is less than 2% in a case of comparison of SLN status with a histological finding in the remaining lymph nodes in the Iymphatic basin. However, the incidence of lymphatic metastases in the adjacent lymphatic basins varies in patients with negative SLN from4% to 27% duringthe follow-up (Mariani G et a1.JNucl Med 2002; 43: 811-827). The aim of the study was to evaluate this parameter in a large group ofpatients. Methods: 170 consecutive patients with MM underwent SLN biopsy and subsequently were followed at the Dept. of Oncology. 2 patients were excluded from the study due to the local recurrence with secondary lymph node metastasis, therefore a total of 168 patients were studied. Loca1ization of MMs: 91 trunk, 67 extremities, 10 head and neck. TNM classification: 48 pTI, 65 pT2, 32 pT3, 19 pT4, 4 pTiS. T
dcterms:title
Efficacy of sentinel lymph node biopsy in patients with malignant melanoma Spolehlivost biopsie sentinelových uzlin u maligního melanomu Efficacy of sentinel lymph node biopsy in patients with malignant melanoma
skos:prefLabel
Efficacy of sentinel lymph node biopsy in patients with malignant melanoma Spolehlivost biopsie sentinelových uzlin u maligního melanomu Efficacy of sentinel lymph node biopsy in patients with malignant melanoma
skos:notation
RIV/61989592:15110/07:00004356!RIV08-MSM-15110___
n3:strany
168
n3:aktivita
n5:S
n3:aktivity
S
n3:cisloPeriodika
6
n3:dodaniDat
n11:2008
n3:domaciTvurceVysledku
n12:9012508 n12:8247366 n12:3611949 n12:3109607
n3:druhVysledku
n8:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
419331
n3:idVysledku
RIV/61989592:15110/07:00004356
n3:jazykVysledku
n17:eng
n3:klicovaSlova
sentinel lymph node biopsy; malignant melanoma
n3:klicoveSlovo
n10:malignant%20melanoma n10:sentinel%20lymph%20node%20biopsy
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[5252C6C1071B]
n3:nazevZdroje
Nuklearmedizin
n3:obor
n4:FD
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n11:2007
n3:svazekPeriodika
46
n3:tvurceVysledku
Hirňák, J. Bajgar, Robert Koranda, Pavel Beneš, Petr Mysliveček, Miroslav Molitor, M. Kamínek, Milan
s:issn
0029-5566
s:numberOfPages
1
n16:organizacniJednotka
15110