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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F06%3A00003940%21RIV08-MZ0-15110___
rdf:type
n8:Vysledek skos:Concept
dcterms:description
BACKGROUND: Incidence and mortality rates of upper aerodigestive tract cancers in Central Europe are among the highest in the world and have increased substantially in recent years. This increase is likely to be due to patterns of alcohol and tobacco consumption. Genetic susceptibility to upper aerodigestive tract cancer in relation to such exposures is an important aspect that should be investigated among populations in this region. METHODS: A multicenter case-control study comprising 811 upper aerodigestive tract cancer cases and 1,083 controls was conducted in: Bucharest (Romania), Lodz (Poland), Moscow (Russia), Banska Bystrika (Slovakia), and Olomouc and Prague (Czech Republic). We analyzed six SNPs in three genes related to ethanol metabolism: alcohol dehydrogenase 1B and 1C (ADH1B, ADH1C) and aldehyde dehydrogenase 2 (ALDH2). RESULTS: The ADH1B histidine allele at codon 48 was associated with a decreased risk of upper aerodigestive tract cancer; odds ratios (OR) were 0.36 [95% confidence interv BACKGROUND: Incidence and mortality rates of upper aerodigestive tract cancers in Central Europe are among the highest in the world and have increased substantially in recent years. This increase is likely to be due to patterns of alcohol and tobacco consumption. Genetic susceptibility to upper aerodigestive tract cancer in relation to such exposures is an important aspect that should be investigated among populations in this region. METHODS: A multicenter case-control study comprising 811 upper aerodigestive tract cancer cases and 1,083 controls was conducted in: Bucharest (Romania), Lodz (Poland), Moscow (Russia), Banska Bystrika (Slovakia), and Olomouc and Prague (Czech Republic). We analyzed six SNPs in three genes related to ethanol metabolism: alcohol dehydrogenase 1B and 1C (ADH1B, ADH1C) and aldehyde dehydrogenase 2 (ALDH2). RESULTS: The ADH1B histidine allele at codon 48 was associated with a decreased risk of upper aerodigestive tract cancer; odds ratios (OR) were 0.36 [95% confidence interv Multicentrická studie případů a kontrol zahrnující 811 případů nádorů horního aerodigestivního traktu a 1083 kontrol, provedená v Rumunsku, Polsku, Rusku, Slovensku a České republice. Byla analyzována úloha tří genů ve vztahu k metabolismu ethanolu a to alkohol dehydrogenáza 1B a 1C (ADH1B, ADH1C) a aldehyd dehydrogenáza 2 (ALDH2).
dcterms:title
Evidence for an important role of alcohol- and aldehyde-metabolizing genes in cancers of the upper aerodigestive tract. Důkaz významné úlohy alkohol a aldehyd metabolizujících genů u nádorů horního aerodigestivního traktu Evidence for an important role of alcohol- and aldehyde-metabolizing genes in cancers of the upper aerodigestive tract.
skos:prefLabel
Důkaz významné úlohy alkohol a aldehyd metabolizujících genů u nádorů horního aerodigestivního traktu Evidence for an important role of alcohol- and aldehyde-metabolizing genes in cancers of the upper aerodigestive tract. Evidence for an important role of alcohol- and aldehyde-metabolizing genes in cancers of the upper aerodigestive tract.
skos:notation
RIV/61989592:15110/06:00003940!RIV08-MZ0-15110___
n3:strany
696-703
n3:aktivita
n14:P
n3:aktivity
P(NR9029)
n3:cisloPeriodika
4
n3:dodaniDat
n6:2008
n3:domaciTvurceVysledku
n4:2512343
n3:druhVysledku
n15:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
474806
n3:idVysledku
RIV/61989592:15110/06:00003940
n3:jazykVysledku
n18:eng
n3:klicovaSlova
alcohol and aledyde-metabolizing genes; cancers; upper aerodigestive tract
n3:klicoveSlovo
n11:upper%20aerodigestive%20tract n11:alcohol%20and%20aledyde-metabolizing%20genes n11:cancers
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[1B4A4EA9320F]
n3:nazevZdroje
Cancer Epidemiology, Biomarkers & Prevention (print)
n3:obor
n13:FN
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
15
n3:projekt
n7:NR9029
n3:rokUplatneniVysledku
n6:2006
n3:svazekPeriodika
15
n3:tvurceVysledku
Boffetta, Paolo Mates, Dana Bencko, Vladimír Chabrier, Amelie Brennan, Paul Fabianova, Elenonora Moullan, Norman Hashibe, Mia Hall, Janet Zaridze, David Janout, Vladimír Shangina, Oxana Canzian, Federico Hung, Rayjean J. Szeszenia-Dabrowska, Neonila
s:issn
1055-9965
s:numberOfPages
8
n16:organizacniJednotka
15110