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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F06%3A00003197%21RIV07-MZ0-15110___
rdf:type
skos:Concept n17:Vysledek
dcterms:description
V purinové de novo syntéze byly popsány dva dědičné deficity. Oba tyto enzymové defekty jsou diagnostikovány detekcí ribosidů - defosforylovaných substrátů enzymů - v moči pacienta. Popisujeme zde syntézu a hmotnostně spektrofotometrickou fragmentaci ribosidů, které mají potenciální význam pro diagnostiku defektů ve druhé polovině dráhy. Všechny látky kromě 5-amino-4-imidazolsukcinokarboxamidribosidu byly syntetizovány chemicky z komerčně dostupného 5-amino-4-imidazolkarboxamidribosidu. Fragmentační spektra sloučenin byla získána analýzou na hmotnostním spektrofotometru s iontovou pastí. Během fragmentace nebylo pozorováno otevírání imidazolového kruhu u žádné ze sloučenin. Hlavní směr fragmentace byl dán postupnou ztrátou substituentů ve formě malých molekul (NH3, CO2, CO). Fragmentace ribosové části byla dána ztrátou molekul vody s následným rozbitím kruhu nebo jeho odštípnutím od imidazolového kruhu jako celku. Two inherited deficiencies have been described in purine de novo synthesis pathway. Both the defects are diagnosed by detecting ribosides-dephosphorylated substrates of the enzymes-in patient's urine. We describe here a synthesis and mass spectrometric fragmentation of ribosides potentially of diagnostic importance for defects in the second part of the pathway. All the species, except 5-amino-4-imidazolesuccinocarboxamideriboside can be synthesized from the commercially available 5-amino-4-imidazolecarboxamideriboside by chemical methods. Fragmentation spectra of the compounds were obtained by the ion trap mass spectrometry. During fragmentation an opening of the imidazole ring was not observed for any of the compounds but loss of its substituents in the form of small molecules (NH3, CO2, CO) is the major route of fragmentation. The ribose moiety cleaves off molecule(s) of water, undergoes a cross-ring cleavage or breaks away as a whole. Copyright (C) Taylor & Francis Group, LLC. Two inherited deficiencies have been described in purine de novo synthesis pathway. Both the defects are diagnosed by detecting ribosides-dephosphorylated substrates of the enzymes-in patient's urine. We describe here a synthesis and mass spectrometric fragmentation of ribosides potentially of diagnostic importance for defects in the second part of the pathway. All the species, except 5-amino-4-imidazolesuccinocarboxamideriboside can be synthesized from the commercially available 5-amino-4-imidazolecarboxamideriboside by chemical methods. Fragmentation spectra of the compounds were obtained by the ion trap mass spectrometry. During fragmentation an opening of the imidazole ring was not observed for any of the compounds but loss of its substituents in the form of small molecules (NH3, CO2, CO) is the major route of fragmentation. The ribose moiety cleaves off molecule(s) of water, undergoes a cross-ring cleavage or breaks away as a whole. Copyright (C) Taylor & Francis Group, LLC.
dcterms:title
Synthesis and mass spectrometric fragmentation characteristics of imidazole ribosides-analogs of intermediates of purine de novo synthetic pathway Syntéza a charakteristická hmotnostně spektrofotometrická fragmentace imidazolových ribosidů - analoga meziproduktů purinové de novo syntézy. Synthesis and mass spectrometric fragmentation characteristics of imidazole ribosides-analogs of intermediates of purine de novo synthetic pathway
skos:prefLabel
Syntéza a charakteristická hmotnostně spektrofotometrická fragmentace imidazolových ribosidů - analoga meziproduktů purinové de novo syntézy. Synthesis and mass spectrometric fragmentation characteristics of imidazole ribosides-analogs of intermediates of purine de novo synthetic pathway Synthesis and mass spectrometric fragmentation characteristics of imidazole ribosides-analogs of intermediates of purine de novo synthetic pathway
skos:notation
RIV/61989592:15110/06:00003197!RIV07-MZ0-15110___
n3:strany
1237-1240
n3:aktivita
n11:P
n3:aktivity
P(NR7796)
n3:cisloPeriodika
11
n3:dodaniDat
n16:2007
n3:domaciTvurceVysledku
n9:4316851 n9:7415540 n9:2714035 n9:6401309
n3:druhVysledku
n8:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
502791
n3:idVysledku
RIV/61989592:15110/06:00003197
n3:jazykVysledku
n18:eng
n3:klicovaSlova
Inherited defects; Metabolism; Purine de novo synthesis
n3:klicoveSlovo
n4:Inherited%20defects n4:Metabolism n4:Purine%20de%20novo%20synthesis
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[2B7FC5534CFA]
n3:nazevZdroje
Nucleosides Nucleotides Nucleic Acids
n3:obor
n13:CE
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
6
n3:projekt
n15:NR7796
n3:rokUplatneniVysledku
n16:2006
n3:svazekPeriodika
25
n3:tvurceVysledku
Adam, Tomáš Fryčák, Petr Vyskočilová, P. Lemr, Karel Horník, P. Friedecký, David
s:issn
1525-7770
s:numberOfPages
4
n5:organizacniJednotka
15110