This HTML5 document contains 54 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n15http://localhost/temp/predkladatel/
n13http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n7http://linked.opendata.cz/resource/domain/vavai/projekt/
n16http://linked.opendata.cz/ontology/domain/vavai/
n14http://linked.opendata.cz/resource/domain/vavai/zamer/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n4http://linked.opendata.cz/ontology/domain/vavai/riv/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
n19http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F61989592%3A15110%2F06%3A00003106%21RIV07-GA0-15110___/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n5http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n11http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n18http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n10http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n17http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n12http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n9http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F06%3A00003106%21RIV07-GA0-15110___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Cytochrome P450 (CYP) 1A1 attracts attention mainly because of its role in production of carcinogenic reactive metabolites from polycyclic aromatic hydrocarbons such as benzo[a]pyrene, but recent developments indicate its apparent role in cell cycle progression. Expression of the enzyme is subject to regulation by aryl hydrocarbon receptor (AhR). It has been shown that induction of CYP 1A1 in HepG2 cells and primary rat hepatocytes by tetrachloro-p-dibenzodioxin (TCDD) is diminished by colchicine and nocodazole. Both compounds decrease CYP1A1 mRNA, protein, and activity levels in HepG2 cells and mRNA level in primary rat hepatocytes. Neither compound significantly affected [(3)H]-TCDD binding to AhR, thus their effect on AhR transcriptional activity proceeds via indirect means. For colchicine and nocodazole are well-known microtubule interfering agents, we also assessed their effect on microtubule integrity in both cell types under investigation. Both compounds disrupt cytoskeleton integrity with diff Cytochrom P450 (CYP) 1A1 přitahuje pozornost hlavně prosvou úlohu v tvorbě karcinogenních reaktivních metabolitů z polycyklických aromatických uhlovodíků jako je benzo-a-pyren, ale recentní poznatky naznačují jeho zapojení do regulace buněčného cyklu. Exprese tohoto enzymu je regulována receptorem pro aromatické uhlovodíky (AhR). Ukázali jsme, že indukce CYP1A1 dioxinem v primárních potkaních hepatocytech a HepG2 buňkách je narušena kolchicinem a nokodazolem. Obě sloučeniny snížily obsah CYP1A1 proteinu, mRNA a katalytickou aktivitu v HepG2 buňkách a primárních potkaních hepatocytech. Žádná ze sloučenin neovlivnila vazbu 3H-TCDD do AhR, tedy jejich účinek na transkripční aktivitu AhR je nepřímý. Jelikož kolchicin a nokodazol jsou látky narušující mikrotubuly, zkoumali jsme jejich účinek na integritu mikrotubulů v obou typech buněk.Obě sloučeniny rozbily mikrotubulární síť s odlišnou účinností, v závislosti na typu buněk. Pozorované potlačení transkripční aktivity AhR kolchicinem a nokodazolem by v Hep Cytochrome P450 (CYP) 1A1 attracts attention mainly because of its role in production of carcinogenic reactive metabolites from polycyclic aromatic hydrocarbons such as benzo[a]pyrene, but recent developments indicate its apparent role in cell cycle progression. Expression of the enzyme is subject to regulation by aryl hydrocarbon receptor (AhR). It has been shown that induction of CYP 1A1 in HepG2 cells and primary rat hepatocytes by tetrachloro-p-dibenzodioxin (TCDD) is diminished by colchicine and nocodazole. Both compounds decrease CYP1A1 mRNA, protein, and activity levels in HepG2 cells and mRNA level in primary rat hepatocytes. Neither compound significantly affected [(3)H]-TCDD binding to AhR, thus their effect on AhR transcriptional activity proceeds via indirect means. For colchicine and nocodazole are well-known microtubule interfering agents, we also assessed their effect on microtubule integrity in both cell types under investigation. Both compounds disrupt cytoskeleton integrity with diff
dcterms:title
Zapojení cytoskeletu do AhR-závislé exprese CYP1A1 Involvement of cytoskeleton in AhR-dependent CYP1A1 expression Involvement of cytoskeleton in AhR-dependent CYP1A1 expression
skos:prefLabel
Zapojení cytoskeletu do AhR-závislé exprese CYP1A1 Involvement of cytoskeleton in AhR-dependent CYP1A1 expression Involvement of cytoskeleton in AhR-dependent CYP1A1 expression
skos:notation
RIV/61989592:15110/06:00003106!RIV07-GA0-15110___
n4:strany
301-313
n4:aktivita
n10:Z n10:P
n4:aktivity
P(1P05ME767), P(GP303/04/P074), Z(MSM6198959216)
n4:cisloPeriodika
3
n4:dodaniDat
n9:2007
n4:domaciTvurceVysledku
n13:4908171 n13:8069239 n13:2514559 n13:1030957
n4:druhVysledku
n12:J
n4:duvernostUdaju
n11:S
n4:entitaPredkladatele
n19:predkladatel
n4:idSjednocenehoVysledku
480383
n4:idVysledku
RIV/61989592:15110/06:00003106
n4:jazykVysledku
n18:eng
n4:klicovaSlova
AhR receptor; Cell Cycle; Cytochrome P450; Drug Metabolism; Microtubules
n4:klicoveSlovo
n5:Cell%20Cycle n5:Cytochrome%20P450 n5:Drug%20Metabolism n5:Microtubules n5:AhR%20receptor
n4:kodStatuVydavatele
NL - Nizozemsko
n4:kontrolniKodProRIV
[E360CD985C8D]
n4:nazevZdroje
Current Drug Metabolism
n4:obor
n17:CE
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
6
n4:projekt
n7:1P05ME767 n7:GP303%2F04%2FP074
n4:rokUplatneniVysledku
n9:2006
n4:svazekPeriodika
7
n4:tvurceVysledku
Maurel, Patrick Pascussi, Jean-Marc Modrianský, Martin Vrzal, Radim Dvořák, Zdeněk Ulrichová, Jitka
n4:zamer
n14:MSM6198959216
s:issn
1389-2002
s:numberOfPages
13
n15:organizacniJednotka
15110