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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F06%3A00003103%21RIV07-GA0-15110___
rdf:type
n5:Vysledek skos:Concept
dcterms:description
Bezpečnost subchronické dávky sanguiritrinu, směsi kvarterních benzo[c]fenanthridinových alkaloidů (KBA) sanguinarinu (SA) a chelerythrinu (CHE), izolované z Macleaya cordata byla studována na potkanech. Potkani byli krmeni dietou obsahující 120 ppm sanguiritrinu (100 ppm KBA) po dobu 109 dní. Průběžně byla sledována spotřeba krmiva a hmotnost zvířat. Obsah KBA ve vybraných tkáních a v plasmě byl stanoven HPLC. Přibližně 2 % KBA byly absorbovány v GIT a 98 % bylo vyloučeno trusem. Hladina bilirubinu, močoviny, kreatininu, glomerulární filtrace, AST, ALT, GMT, ALP a celková antioxidační kapacita byly stanoveny v plasmě. V játrech bylo změřeno množství GSH, lipoperoxidačních produktů, aktivita SOD a GPx a celkové množství cytochromu P450. Poškození jaderné DNA bylo sledováno; metodou 32P-postlabelingu nebyly detekovány DNA-adukty v jaterní jaderné ani v mitochondriální DNA. Na potkanech nebyly pozorovány žádné nežádoucí změny. KBA nezpůsobily změny na epitelu střeva, jaterní tkáni a neovlivnily žádný z The subchronic safety of sanguiritrin, a mixture of sanguinarine (SA) and chelerythrine (CHE) quaternary benzo[c]phenanthridine alkaloids (QBA), obtained from Macleaya cordata was assessed. Rats were fed a diet containing 120 ppm sanguiritrin (100 ppm QBA) for 109 days. The feed consumption and the animal weight were monitored. The content of QBA in selected tissues and plasma was determined using HPLC. It was evidenced that 2 % of QBA were absorbed through the GIT while 98 % were excreted in the feces. In plasma, bilirubin, urea, creatinine, glomerular filtration, AST, ALT, GMT, ALP and total antioxidant capacity were determined. In liver, GSH level, lipoperoxidation products, SOD and GPx activities and total amount of cytochrome P450 were evaluated. Damage to nuclear DNA was assessed; a 32P-postlabeling assay proved that no DNA-adducts were detected in nuclear and mitochrondrial DNA in liver. No adverse effects were observed on rat organism. QBA had no influence on the gut mucosal epithelium, liver The subchronic safety of sanguiritrin, a mixture of sanguinarine (SA) and chelerythrine (CHE) quaternary benzo[c]phenanthridine alkaloids (QBA), obtained from Macleaya cordata was assessed. Rats were fed a diet containing 120 ppm sanguiritrin (100 ppm QBA) for 109 days. The feed consumption and the animal weight were monitored. The content of QBA in selected tissues and plasma was determined using HPLC. It was evidenced that 2 % of QBA were absorbed through the GIT while 98 % were excreted in the feces. In plasma, bilirubin, urea, creatinine, glomerular filtration, AST, ALT, GMT, ALP and total antioxidant capacity were determined. In liver, GSH level, lipoperoxidation products, SOD and GPx activities and total amount of cytochrome P450 were evaluated. Damage to nuclear DNA was assessed; a 32P-postlabeling assay proved that no DNA-adducts were detected in nuclear and mitochrondrial DNA in liver. No adverse effects were observed on rat organism. QBA had no influence on the gut mucosal epithelium, liver
dcterms:title
Posouzení bezpečnosti sanguiritrinu, frakce alkaloidů z Macleaya cordata, na potkanech Safety assessment of sanguiritrin, alkaloid fraction of Macleya cordata, in rats Safety assessment of sanguiritrin, alkaloid fraction of Macleya cordata, in rats
skos:prefLabel
Posouzení bezpečnosti sanguiritrinu, frakce alkaloidů z Macleaya cordata, na potkanech Safety assessment of sanguiritrin, alkaloid fraction of Macleya cordata, in rats Safety assessment of sanguiritrin, alkaloid fraction of Macleya cordata, in rats
skos:notation
RIV/61989592:15110/06:00003103!RIV07-GA0-15110___
n3:strany
145-155
n3:aktivita
n7:Z n7:P
n3:aktivity
P(GP203/03/D237), Z(MSM6198959216)
n3:cisloPeriodika
4
n3:dodaniDat
n12:2007
n3:domaciTvurceVysledku
n4:7925662 n4:2706571 n4:8738394 n4:6670784 n4:8341362 n4:8321124 n4:3540693 n4:2326868 n4:5773458 n4:2514559 n4:8419647 n4:4594266
n3:druhVysledku
n15:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
498354
n3:idVysledku
RIV/61989592:15110/06:00003103
n3:jazykVysledku
n18:eng
n3:klicovaSlova
Benzo[c]phenanthridine alkaloids; Oral administration; Biochemical markers; Oxidative stress; DNA damage; Cytochrome P450
n3:klicoveSlovo
n8:Biochemical%20markers n8:Benzo%5Bc%5Dphenanthridine%20alkaloids n8:Oxidative%20stress n8:DNA%20damage n8:Oral%20administration n8:Cytochrome%20P450
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[99FB71FC5A30]
n3:nazevZdroje
Veterinární medicína
n3:obor
n19:CE
n3:pocetDomacichTvurcuVysledku
12
n3:pocetTvurcuVysledku
13
n3:projekt
n9:GP203%2F03%2FD237
n3:rokUplatneniVysledku
n12:2006
n3:svazekPeriodika
51
n3:tvurceVysledku
Kosina, Pavel Lichnovský, Václav Svobodová, Alena Zdařilová, Adéla Jirovský, David Stiborová, Marie Anzenbacherová, Eva Psotová, Jitka Šimánek, Vilím Hrbáč, Jan Večeřa, Rostislav Vičar, Jaroslav Ulrichová, Jitka
n3:zamer
n13:MSM6198959216
s:issn
0375-8427
s:numberOfPages
11
n14:organizacniJednotka
15110